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Wieduwilt, P., Paschen, B., Schreeck, H., Schwenker, B., Soltau, J., Ahlburg, P., et al. (2021). Performance of production modules of the Belle II pixel detector in a high-energy particle beam. Nucl. Instrum. Methods Phys. Res. A, 991, 164978–15pp.
Abstract: The Belle II experiment at the Super B factory SuperKEKB, an asymmetric e(+) e(-) collider located in Tsukuba, Japan, is tailored to perform precision B physics measurements. The centre of mass energy of the collisions is equal to the rest mass of the gamma (4S) resonance of m(gamma(4S)) = 10.58 GeV. A high vertex resolution is essential for measuring the decay vertices of B mesons. Typical momenta of the decay products are ranging from a few tens of MeV to a few GeV and multiple scattering has a significant impact on the vertex resolution. The VerteX Detector (VXD) for Belle II is therefore designed to have as little material as possible inside the acceptance region. Especially the innermost two layers, populated by the PiXel Detector (PXD), have to be ultra-thin. The PXD is based on DEpleted P-channel Field Effect Transistors (DEPFETs) with a thickness of only 75 μm. Spatial resolution and hit efficiency of production detector modules were studied in beam tests performed at the DESY test beam facility. The spatial resolution was investigated as a function of the incidence angle and improvements due to charge sharing are demonstrated. The measured module performance is compatible with the requirements for Belle II.
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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Di Valentino, E., Mena, O., Pan, S., Visinelli, L., Yang, W. Q., Melchiorri, A., et al. (2021). In the realm of the Hubble tension – a review of solutions. Class. Quantum Gravity, 38(15), 153001–110pp.
Abstract: The simplest ΛCDM model provides a good fit to a large span of cosmological data but harbors large areas of phenomenology and ignorance. With the improvement of the number and the accuracy of observations, discrepancies among key cosmological parameters of the model have emerged. The most statistically significant tension is the 4 sigma to 6 sigma disagreement between predictions of the Hubble constant, H (0), made by the early time probes in concert with the 'vanilla' ΛCDM cosmological model, and a number of late time, model-independent determinations of H (0) from local measurements of distances and redshifts. The high precision and consistency of the data at both ends present strong challenges to the possible solution space and demands a hypothesis with enough rigor to explain multiple observations-whether these invoke new physics, unexpected large-scale structures or multiple, unrelated errors. A thorough review of the problem including a discussion of recent Hubble constant estimates and a summary of the proposed theoretical solutions is presented here. We include more than 1000 references, indicating that the interest in this area has grown considerably just during the last few years. We classify the many proposals to resolve the tension in these categories: early dark energy, late dark energy, dark energy models with 6 degrees of freedom and their extensions, models with extra relativistic degrees of freedom, models with extra interactions, unified cosmologies, modified gravity, inflationary models, modified recombination history, physics of the critical phenomena, and alternative proposals. Some are formally successful, improving the fit to the data in light of their additional degrees of freedom, restoring agreement within 1-2 sigma between Planck 2018, using the cosmic microwave background power spectra data, baryon acoustic oscillations, Pantheon SN data, and R20, the latest SH0ES Team Riess, et al (2021 Astrophys. J. 908 L6) measurement of the Hubble constant (H (0) = 73.2 +/- 1.3 km s(-1) Mpc(-1) at 68% confidence level). However, there are many more unsuccessful models which leave the discrepancy well above the 3 sigma disagreement level. In many cases, reduced tension comes not simply from a change in the value of H (0) but also due to an increase in its uncertainty due to degeneracy with additional physics, complicating the picture and pointing to the need for additional probes. While no specific proposal makes a strong case for being highly likely or far better than all others, solutions involving early or dynamical dark energy, neutrino interactions, interacting cosmologies, primordial magnetic fields, and modified gravity provide the best options until a better alternative comes along.
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Giare, W., Di Valentino, E., Melchiorri, A., & Mena, O. (2021). New cosmological bounds on hot relics: axions and neutrinos. Mon. Not. Roy. Astron. Soc., 505(2), 2703–2711.
Abstract: Axions, if realized in nature, can be copiously produced in the early universe via thermal processes, contributing to the mass-energy density of thermal hot relics. In light of the most recent cosmological observations, we analyse two different thermal processes within a realistic mixed hot dark matter scenario which includes also massive neutrinos. Considering the axion-gluon thermalization channel, we derive our most constraining bounds on the hot relic masses m(a) < 7.46 eV and Sigma m(nu) < 0.114 eV both at 95 percent CL; while studying the axion-pion scattering, without assuming any specific model for the axion-pion interactions, and remaining in the range of validity of the chiral perturbation theory, our most constraining bounds are improved to m(a) < 0.91 eV and Sigma m(nu) < 0.105 eV, both at 95 percent CL. Interestingly, in both cases, the total neutrino mass lies very close to the inverted neutrino mass ordering prediction. If future terrestrial double beta decay and/or long-baseline neutrino experiments find that the nature mass ordering is the inverted one, this could rule out a wide region in the currently allowed thermal axion window. Our results therefore, strongly support multi messenger searches of axions and neutrino properties, together with joint analyses of their expected sensitivities.
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Di Valentino, E. et al, & Mena, O. (2021). Cosmology intertwined III: f sigma(8) and S-8. Astropart Phys., 131, 102604–6pp.
Abstract: The standard A Cold Dark Matter cosmological model provides a wonderful fit to current cosmological data, but a few statistically significant tensions and anomalies were found in the latest data analyses. While these anomalies could be due to the presence of systematic errors in the experiments, they could also indicate the need for new physics beyond the standard model. In this Letter of Interest we focus on the tension between Planck data and weak lensing measurements and redshift surveys, in the value of the matter energy density Omega(m), and the amplitude sigma(8) (or the growth rate f sigma(8)) of cosmic structure. We list a few promising models for solving this tension, and discuss the importance of trying to fit multiple cosmological datasets with complete physical models, rather than fitting individual datasets with a few handpicked theoretical parameters.
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