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Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
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Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
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Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
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Volume |
35 |
Issue |
5 |
Pages |
446-452 |
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Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
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Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
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Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
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Lippincott Williams & Wilkins |
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English |
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ISSN |
0143-3636 |
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Notes |
WOS:000334103800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial  |
1763 |
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Author |
Krzysiek, M. et al; Gadea, A.; Huyuk, T.; Barrientos, D. |
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Title |
Study of the soft dipole modes in Ce-140 via inelastic scattering of O-17 |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physica Scripta |
Abbreviated Journal |
Phys. Scr. |
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Volume |
89 |
Issue |
5 |
Pages |
054016 - 6pp |
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Keywords |
pygmy dipole resonances; inelastic scattering; AGATA detector; gamma spectroscopy |
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Abstract |
The main aim of this study was a deeper understanding of the nuclear structure properties of the soft dipole modes in Ce-140, excited via inelastic scattering of weakly bound O-17 projectiles. An important aim was to investigate the 'splitting' of the PDR into two parts: a low-energy isoscalar component dominated by neutron-skin oscillations and a higher-energy component lying on the tail of the giant dipole resonance of a rather isovector character. This was already observed for this nucleus, investigated in (alpha, alpha') and (gamma,gamma') experiments. The experiment was performed at Laboratori Nazionali di Legnaro, Italy. Inelastic scattering of O-17 ion beam at 20 MeV A(-1) was used to excite the resonance modes in the Ce-140 target. Gamma-rays were registered by five triple clusters of AGATA-Demonstrator and nine large volume scintillators (LaBr3). The scattered O-17 ions were identified by two Delta E – E Si telescopes of the TRACE array mounted inside the scattering chamber. The telescopes consisted of two segmented Si-pad detectors, each of 60 pixels. Very preliminary data have shown a strong domination of the E1 transitions in the 'pygmy' region with a character more similar to the one obtained in alpha scattering experiment. |
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Address |
[Krzysiek, M.; Kmiecik, M.; Maj, A.; Bednarczyk, P.; Ciemala, M.; Fornal, B.; Grebosz, J.; Mazurek, K.; Meczynski, W.; Zieblinski, M.] Polish Acad Sci, H Niewodniczanski Inst Nucl Phys, Krakow, Poland, Email: mateusz.krzysiek@ifj.edu.pl |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-8949 |
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Notes |
WOS:000335785300016 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1790 |
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Author |
Anderson, L. et al; Mena, O. |
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Title |
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: baryon acoustic oscillations in the Data Releases 10 and 11 Galaxy samples |
Type |
Journal Article |
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Year |
2014 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
441 |
Issue |
1 |
Pages |
24-62 |
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Keywords |
cosmological parameters; cosmology: observations; dark energy; distance scale; large-scale structure of Universe |
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Abstract |
We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations (BAO) in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 (DR11) sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released DR9 and DR10 samples. Assuming a concordance A cold dark matter (ACDM) cosmological model, the DR11 sample covers a volume of 13 Gpc(3) and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density- field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7s in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, r(d), which has a value of r(d,fid) = 149.28 Mpc in our fiducial cosmology. We find D-V = (1264 +/- 25 Mpc)(r(d)/r(d,fid)) at z = 0.32 and D-V = (2056 +/- 20 Mpc)(r(d)/r(d,fid)) at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of D-A = (1421 +/- 20 Mpc)(r(d)/r(d,fid)) and H = (96.8 +/- 3.4 kms(-1) Mpc(-1))(r(d),(fid)/r(d)). Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. |
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Address |
[Anderson, Lauren; Bhardwaj, Vaishali] Univ Washington, Dept Astron, Seattle, WA 98195 USA, Email: djschlegel@lbl.gov; |
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Oxford Univ Press |
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English |
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ISSN |
0035-8711 |
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Notes |
WOS:000336249300002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1791 |
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Author |
Ros, A.; Lerche, C.W.; Sebastia, A.; Sanchez, F.; Benlloch, J.M. |
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Title |
Retroreflector arrays for better light collection efficiency of gamma-ray imaging detectors with continuous scintillation crystals without DOI misestimation |
Type |
Journal Article |
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Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
9 |
Issue |
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Pages |
P04009 - 14pp |
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Keywords |
Gamma detectors (scintillators, CZT, HPG, HgI etc); Interaction of radiation with matter; Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Detector design and construction technologies and materials |
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Abstract |
A method to improve light collection efficiency of gamma-ray imaging detectors by using retroreflector arrays has been tested, simulations of the behaviour of the scintillation light illuminating the retroreflector surface have been made. Measurements including retroreflector arrays in the setup have also been taken. For the measurements, positron emission tomography (PET) detectors with continuous scintillation crystals have been used. Each detector module consists of a continuous LSO-scintillator of dimensions 49x49x10 mm(3) and a H8500 position-sensitive photo-multiplier (PSPMT) from Hamamatsu. By using a continuous scintillation crystal, the scintillation light distribution has not been destroyed and the energy, the centroids along the x- and y-direction and the depth of interaction (DOI) can be estimated. Simulations have also been run taking into account the use of continuous scintillation crystals. Due to the geometry of the continuous scintillation crystals in comparison with pixelated crystals, a good light collection efficiency is necessary to correctly reconstruct the impact point of the gamma-ray. The aim of this study is to investigate whether micro-machine retro-reflectors improve light yield without misestimation of the impact point. The results shows an improvement on the energy and centroid resolutions without worsening the depth of interaction resolution. Therefore it can be concluded that using retroreflector arrays at the entrance side of the scintillation crystal improves light collection efficiency without worsening the impact point estimation. |
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Address |
[Ros, A.] Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: anrogar2@i3m.upv.es |
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Publisher |
Iop Publishing Ltd |
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English |
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Original Title |
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Series Volume |
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ISSN |
1748-0221 |
ISBN |
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Notes |
WOS:000336123800049 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1798 |
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Author |
NEXT Collaboration (Alvarez, V. et al); Carcel, S.; Cervera-Villanueva, A.; Diaz, J.; Ferrario, P.; Gil, A.; Gomez-Cadenas, J.J.; Laing, A.; Liubarsky, I.; Lorca, D.; Martin-Albo, J.; Martinez, A.; Monrabal, F.; Muñoz Vidal, J.; Nebot-Guinot, M.; Rodriguez, J.; Serra, L.; Simon, A.; Sorel, M.; Yahlali, N. |
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Title |
Description and commissioning of NEXT-MM prototype: first results from operation in a Xenon-Trimethylamine gas mixture |
Type |
Journal Article |
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Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
9 |
Issue |
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Pages |
P03010 - 22pp |
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Keywords |
Time projection chambers; Particle tracking detectors (Gaseous detectors); Double-beta decay detectors |
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Abstract |
A technical description of NEXT-MM and its commissioning and first performance is reported. Having an active volume of similar to 35 cm drift x 28 cm diameter, it constitutes the largest Micromegas-read TPC operated in Xenon ever constructed, made by a sectorial arrangement of the 4 largest single wafers manufactured with the Microbulk technique to date. It is equipped with a suitably pixelized readout and with a sufficiently large sensitive volume (similar to 23 l) so as to contain long (similar to 20 cm) electron tracks. First results obtained at 1 bar for Xenon and Trymethylamine (Xe-(2%) TMA) mixture are presented. The TPC can accurately reconstruct extended background tracks. An encouraging full-width half-maximum of 11.6% was obtained for similar to 29 keV gammas without resorting to any data post-processing. |
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Address |
[Alvarez, V.; Carcel, S.; Cervera, A.; Diaz, J.; Ferrario, P.; Gil, A.; Gomez-Cadenas, J. J.; Laing, A.; Liubarsky, I.; Lorca, D.; Martin-Albo, J.; Martinez, A.; Monrabal, F.; Munoz Vidal, J.; Nebot-Guinot, M.; Rodriguez, J.; Serra, L.; Simon, A.; Sorel, M.; Yahlali, N.] CSIC, Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: gomez@lal.in2p3.fr; |
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Publisher |
Iop Publishing Ltd |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Conference |
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Notes |
WOS:000336123200070 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1800 |
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