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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Public Library Science |
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Language |
English |
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Edition |
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ISSN |
1545-7885 |
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Expedition |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial ![sorted by Serial field, descending order (down)](img/sort_desc.gif) |
1446 |
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Author |
Strege, C.; Bertone, G.; Feroz, F.; Fornasa, M.; Ruiz de Austri, R.; Trotta, R. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Global fits of the cMSSM and NUHM including the LHC Higgs discovery and new XENON100 constraints |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
013 - 40pp |
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Keywords |
dark matter theory; supersymmetry and cosmology |
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Abstract |
We present global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM) and the Non-Universal Higgs Model (NUHM), including the most recent CMS constraint on the Higgs boson mass, 5.8 fb(-1) integrated luminosity null Supersymmetry searches by ATLAS, the new LHCb measurement of B R ((B) over bar (s) -> mu(+) mu(-)) and the 7-year WMAP dark matter relic abundance determination. We include the latest dark matter constraints from the XENON100 experiment, marginalising over astrophysical and particle physics uncertainties. We present Bayesian posterior and profile likelihood maps of the highest resolution available today, obtained from up to 350M points. We find that the new constraint on the Higgs boson mass has a dramatic impact, ruling out large regions of previously favoured cMSSM and NUHM parameter space. In the cMSSM, light sparticles and predominantly gaugino-like dark matter with a mass of a few hundred GeV are favoured. The NUHM exhibits a strong preference for heavier sparticle masses and a Higgsino-like neutralino with a mass of 1 TeV. The future ton-scale XENON1T direct detection experiment will probe large portions of the currently favoured cMSSM and NUHM parameter space. The LHC operating at 14 TeV collision energy will explore the favoured regions in the cMSSM, while most of the regions favoured in the NUHM will remain inaccessible. Our best-fit points achieve a satisfactory quality-of-fit, with p-values ranging from 0.21 to 0.35, so that none of the two models studied can be presently excluded at any meaningful significance level. |
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Address |
Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Astrophys Grp, London SW7 2AZ, England, Email: charlotte.strege09@imperial.ac.uk; |
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Publisher |
Iop Publishing Ltd |
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English |
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Series Volume |
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Edition |
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ISSN |
1475-7516 |
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Expedition |
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Conference |
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Notes |
WOS:000318556200013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial ![sorted by Serial field, descending order (down)](img/sort_desc.gif) |
1445 |
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Author |
Capozziello, S.; Harko, T.; Koivisto, T.S.; Lobo, F.S.N.; Olmo, G.J. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Cosmology of hybrid metric-Palatini f(X)-gravity |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
011 - 25pp |
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Keywords |
modified gravity; dark energy theory |
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Abstract |
A new class of modified theories of gravity, consisting of the superposition of the metric Einstein-Hilbert Lagrangian with an f(R) term constructed a la Palatini was proposed recently. The dynamically equivalent scalar-tensor representation of the model was also formulated, and it was shown that even if the scalar field is very light, the theory passes the Solar System observational constraints. Therefore the model predicts the existence of a long-range scalar field, modifying the cosmological and galactic dynamics. An explicit model that passes the local tests and leads to cosmic acceleration was also obtained. In the present work, it is shown that the theory can be also formulated in terms of the quantity X equivalent to kappa T-2 + R, where T and R are the traces of the stress-energy and Ricci tensors, respectively. The variable X represents the deviation with respect to the field equation trace of general relativity. The cosmological applications of this hybrid metric-Palatini gravitational theory are also explored, and cosmological solutions coming from the scalar-tensor representation of f(X)-gravity are presented. Criteria to obtain cosmic acceleration are discussed and the field equations are analyzed as a dynamical system. Several classes of dynamical cosmological solutions, depending on the functional form of the effective scalar field potential, describing both accelerating and decelerating Universes are explicitly obtained. Furthermore, the cosmological perturbation equations are derived and applied to uncover the nature of the propagating scalar degree of freedom and the signatures these models predict in the large-scale structure. |
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Address |
Univ Naples Federico II, Dipartimento Fis, Naples, Italy, Email: capozzie@na.infn.it; |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000318556200011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial ![sorted by Serial field, descending order (down)](img/sort_desc.gif) |
1444 |
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Permanent link to this record |
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Author |
Xiao, C.W.; Oset, E. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Three methods to detect the predicted D(D)over-bar scalar meson X(3700) |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
49 |
Issue |
4 |
Pages |
52 - 6pp |
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Keywords |
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Abstract |
In analogy to the f(0)(500), which appears as a pi pi resonance in chiral unitary theory, and the f(0)(980), which appears as a quasibound K (K) over bar state, the extension of this approach to the charm sector also predicts a quasibound D (D) over bar state with mass around 3720 MeV, named as X(3700), for which some experimental support is seen in the e(+)e(-) -> J/psi D (D) over bar reaction close to the D (D) over bar threshold. In the present work we propose three different experiments to observe it as a clear peak. The first one is the radiative decay of the psi(3770), psi(3770) -> gamma X(3700) -> gamma eta eta'. The second one proposes the analogous reaction psi(4040) -> gamma X(3700) -> gamma eta eta' and the third reaction is the e(+)e(-) -> J/psi X(3700) -> J/psi eta eta'. Neat peaks are predicted for all the reactions and the calculated rates are found within measurable range in present facilities. |
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Address |
Univ Valencia, CSIC, Inst Invest Paterna, Ctr Mixto,Dept Fis Teor, Valencia 46071, Spain, Email: xiaochw@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Conference |
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Notes |
WOS:000318424800011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial ![sorted by Serial field, descending order (down)](img/sort_desc.gif) |
1443 |
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Permanent link to this record |
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Author |
Roca, L.; Oset, E. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Lambda(1405) poles obtained from pi(0)Sigma(0) photoproduction data |
Type |
Journal Article |
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Year |
2013 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
87 |
Issue |
5 |
Pages |
055201 - 8pp |
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Keywords |
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Abstract |
We present a strategy to extract the position of the two Lambda(1405) poles from experimental photoproduction data measured recently at different energies in the gamma p -> K+pi(0)Sigma(0) reaction at Jefferson Laboratory. By means of a chiral dynamics motivated potential with free parameters, we solve the Bethe-Salpeter equation in the coupled channels (K) over barN and pi Sigma in isospin I = 0 and parametrize the amplitude for the photonuclear reaction in terms of a linear combination of the pi Sigma -> pi Sigma and (K) over barN -> pi Sigma scattering amplitudes in I = 0, with a different linear combination for each energy. Good fits to the data are obtained with some sets of parameters, by means of which one can also predict the cross section for the K- p -> pi(0)Sigma(0) reaction. These later results help us decide among the possible solutions. The result is that the different solutions lead to two poles similar to those found in the chiral unitary approach. With the best result we find the two Lambda(1405) poles at 1385 – 68i MeV and 1419 – 22i MeV. |
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Address |
Univ Murcia, Dept Fis, E-30100 Murcia, Spain |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0556-2813 |
ISBN |
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Medium |
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Conference |
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Notes |
WOS:000318527400004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial ![sorted by Serial field, descending order (down)](img/sort_desc.gif) |
1442 |
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Permanent link to this record |