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Records |
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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
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Title |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Public Library Science |
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English |
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ISSN |
1545-7885 |
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Expedition |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial  |
1446 |
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Author |
Strege, C.; Bertone, G.; Feroz, F.; Fornasa, M.; Ruiz de Austri, R.; Trotta, R. |
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Title |
Global fits of the cMSSM and NUHM including the LHC Higgs discovery and new XENON100 constraints |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
013 - 40pp |
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Keywords |
dark matter theory; supersymmetry and cosmology |
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Abstract |
We present global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM) and the Non-Universal Higgs Model (NUHM), including the most recent CMS constraint on the Higgs boson mass, 5.8 fb(-1) integrated luminosity null Supersymmetry searches by ATLAS, the new LHCb measurement of B R ((B) over bar (s) -> mu(+) mu(-)) and the 7-year WMAP dark matter relic abundance determination. We include the latest dark matter constraints from the XENON100 experiment, marginalising over astrophysical and particle physics uncertainties. We present Bayesian posterior and profile likelihood maps of the highest resolution available today, obtained from up to 350M points. We find that the new constraint on the Higgs boson mass has a dramatic impact, ruling out large regions of previously favoured cMSSM and NUHM parameter space. In the cMSSM, light sparticles and predominantly gaugino-like dark matter with a mass of a few hundred GeV are favoured. The NUHM exhibits a strong preference for heavier sparticle masses and a Higgsino-like neutralino with a mass of 1 TeV. The future ton-scale XENON1T direct detection experiment will probe large portions of the currently favoured cMSSM and NUHM parameter space. The LHC operating at 14 TeV collision energy will explore the favoured regions in the cMSSM, while most of the regions favoured in the NUHM will remain inaccessible. Our best-fit points achieve a satisfactory quality-of-fit, with p-values ranging from 0.21 to 0.35, so that none of the two models studied can be presently excluded at any meaningful significance level. |
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Address |
Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Astrophys Grp, London SW7 2AZ, England, Email: charlotte.strege09@imperial.ac.uk; |
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Iop Publishing Ltd |
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English |
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Abbreviated Series Title |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318556200013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1445 |
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Author |
Capozziello, S.; Harko, T.; Koivisto, T.S.; Lobo, F.S.N.; Olmo, G.J. |
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Title |
Cosmology of hybrid metric-Palatini f(X)-gravity |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
011 - 25pp |
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Keywords |
modified gravity; dark energy theory |
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Abstract |
A new class of modified theories of gravity, consisting of the superposition of the metric Einstein-Hilbert Lagrangian with an f(R) term constructed a la Palatini was proposed recently. The dynamically equivalent scalar-tensor representation of the model was also formulated, and it was shown that even if the scalar field is very light, the theory passes the Solar System observational constraints. Therefore the model predicts the existence of a long-range scalar field, modifying the cosmological and galactic dynamics. An explicit model that passes the local tests and leads to cosmic acceleration was also obtained. In the present work, it is shown that the theory can be also formulated in terms of the quantity X equivalent to kappa T-2 + R, where T and R are the traces of the stress-energy and Ricci tensors, respectively. The variable X represents the deviation with respect to the field equation trace of general relativity. The cosmological applications of this hybrid metric-Palatini gravitational theory are also explored, and cosmological solutions coming from the scalar-tensor representation of f(X)-gravity are presented. Criteria to obtain cosmic acceleration are discussed and the field equations are analyzed as a dynamical system. Several classes of dynamical cosmological solutions, depending on the functional form of the effective scalar field potential, describing both accelerating and decelerating Universes are explicitly obtained. Furthermore, the cosmological perturbation equations are derived and applied to uncover the nature of the propagating scalar degree of freedom and the signatures these models predict in the large-scale structure. |
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Address |
Univ Naples Federico II, Dipartimento Fis, Naples, Italy, Email: capozzie@na.infn.it; |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318556200011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1444 |
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Author |
Xiao, C.W.; Oset, E. |
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Title |
Three methods to detect the predicted D(D)over-bar scalar meson X(3700) |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
49 |
Issue |
4 |
Pages |
52 - 6pp |
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Keywords |
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Abstract |
In analogy to the f(0)(500), which appears as a pi pi resonance in chiral unitary theory, and the f(0)(980), which appears as a quasibound K (K) over bar state, the extension of this approach to the charm sector also predicts a quasibound D (D) over bar state with mass around 3720 MeV, named as X(3700), for which some experimental support is seen in the e(+)e(-) -> J/psi D (D) over bar reaction close to the D (D) over bar threshold. In the present work we propose three different experiments to observe it as a clear peak. The first one is the radiative decay of the psi(3770), psi(3770) -> gamma X(3700) -> gamma eta eta'. The second one proposes the analogous reaction psi(4040) -> gamma X(3700) -> gamma eta eta' and the third reaction is the e(+)e(-) -> J/psi X(3700) -> J/psi eta eta'. Neat peaks are predicted for all the reactions and the calculated rates are found within measurable range in present facilities. |
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Address |
Univ Valencia, CSIC, Inst Invest Paterna, Ctr Mixto,Dept Fis Teor, Valencia 46071, Spain, Email: xiaochw@ific.uv.es |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318424800011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1443 |
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Author |
Roca, L.; Oset, E. |
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Title |
Lambda(1405) poles obtained from pi(0)Sigma(0) photoproduction data |
Type |
Journal Article |
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Year |
2013 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
87 |
Issue |
5 |
Pages |
055201 - 8pp |
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Keywords |
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Abstract |
We present a strategy to extract the position of the two Lambda(1405) poles from experimental photoproduction data measured recently at different energies in the gamma p -> K+pi(0)Sigma(0) reaction at Jefferson Laboratory. By means of a chiral dynamics motivated potential with free parameters, we solve the Bethe-Salpeter equation in the coupled channels (K) over barN and pi Sigma in isospin I = 0 and parametrize the amplitude for the photonuclear reaction in terms of a linear combination of the pi Sigma -> pi Sigma and (K) over barN -> pi Sigma scattering amplitudes in I = 0, with a different linear combination for each energy. Good fits to the data are obtained with some sets of parameters, by means of which one can also predict the cross section for the K- p -> pi(0)Sigma(0) reaction. These later results help us decide among the possible solutions. The result is that the different solutions lead to two poles similar to those found in the chiral unitary approach. With the best result we find the two Lambda(1405) poles at 1385 – 68i MeV and 1419 – 22i MeV. |
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Address |
Univ Murcia, Dept Fis, E-30100 Murcia, Spain |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0556-2813 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318527400004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1442 |
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| Permanent link to this record |
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Author |
T2K Collaboration (Abe, K. et al); Cervera-Villanueva, A.; Escudero, L.; Gomez-Cadenas, J.J.; Monfregola, L.; Sorel, M.; Stamoulis, P. |
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Title |
Measurement of the inclusive nu(mu) charged current cross section on carbon in the near detector of the T2K experiment |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
87 |
Issue |
9 |
Pages |
092003 - 20pp |
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Keywords |
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Abstract |
T2K has performed the first measurement of nu(mu) inclusive charged current interactions on carbon at neutrino energies of similar to 1 GeV where the measurement is reported as a flux-averaged double differential cross section in muon momentum and angle. The flux is predicted by the beam Monte Carlo and external data, including the results from the NA61/SHINE experiment. The data used for this measurement were taken in 2010 and 2011, with a total of 10.8 x 10(19) protons-on-target. The analysis is performed on 4485 inclusive charged current interaction candidates selected in the most upstream fine-grained scintillator detector of the near detector. The flux-averaged total cross section is <sigma(CC)>(phi) = (6.91 +/- 0.13(stat) +/- 0.84(syst)) x 10(-39) cm(2)/nucleon for a mean neutrino energy of 0.85 GeV. |
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Address |
Univ Alberta, Dept Phys, Ctr Particle Phys, Edmonton, AB, Canada |
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Corporate Author |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1550-7998 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318655700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1441 |
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Author |
Blankenburg, G.; Jones Perez, J. |
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Title |
RGE behavior of SUSY with a U(2)(3) symmetry |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
73 |
Issue |
2 |
Pages |
2289 - 15pp |
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Keywords |
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Abstract |
The first LHC results seem to disfavor, from the point of view of naturalness, any constrained MSSM realization with universal conditions at the SUSY-breaking scale. A more motivated scenario is given by split-family SUSY, in which the first two generations of squarks are heavy, compatible with a U(2)(3) flavor symmetry. We consider this flavor symmetry to be broken at a very high scale and study the consequences at low energies through its RGE evolution. Initial conditions compatible with a split scenario are found, and the preservation of correlations from minimal U(2)(3) breaking are checked. The various chiral operators in Delta F = 2 processes are analyzed, and we show that, due to LHC gluino bounds, the (LL)(RR) operators cannot always be neglected. Finally, we also study a possible extension of the U(2)(3) model compatible with the lepton sector. |
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Address |
Univ Roma Tre, Dipartimento Fis, I-00146 Rome, Italy, Email: joel.jones@uv.es |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318289600004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1440 |
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| Permanent link to this record |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Measurement of the flavour composition of dijet events in pp collisions at root s=7 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
73 |
Issue |
2 |
Pages |
2301 - 30pp |
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Keywords |
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Abstract |
This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at root s = 7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39 pb(-1). Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40 GeV to 500 GeV and jet rapidity vertical bar y vertical bar < 2.1. The fit results agree with the predictions of leading-and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e. g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions. |
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Address |
Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia |
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Corporate Author |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318289600010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1439 |
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| Permanent link to this record |
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Author |
Bertone, V.; Carrasco, N.; Ciuchini, M.; Dimopoulos, P.; Frezzotti, R.; Gimenez, V.; Lubicz, V.; Martinelli, G.; Mescia, F.; Papinutto, M.; Rossi, G.C.; Silvestrini, L.; Simula, S.; Tarantino, C.; Vladikas, A. |
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Title |
Kaon mixing beyond the SM from N-f=2 tmQCD and model independent constraints from the UTA |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
089 - 53pp |
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Keywords |
Lattice QCD; Beyond Standard Model |
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Abstract |
We present the first unquenched, continuum limit, lattice QCD results for the matrix elements of the operators describing neutral kaon oscillations in extensions of the Standard Model. Owing to the accuracy of our calculation on Delta S = 2 weak Hamiltonian matrix elements, we are able to provide a refined Unitarity Triangle analysis improving the bounds coming from model independent constraints on New Physics. In our non-perturbative computation we use a combination of N-f = 2 maximally twisted sea quarks and Osterwalder-Seiler valence quarks in order to achieve both O(a)-improvement and continuum-like renormalization properties for the relevant four-fermion operators. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme. Based on simulations at four values of the lattice spacing and a number of quark masses we have extrapolated/interpolated our results to the continuum limit and physical light/strange quark masses. |
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Address |
Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany, Email: valerio.bertone@cern.ch; |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000317522400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1438 |
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| Permanent link to this record |
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Author |
Beneke, M.; Hellmann, C.; Ruiz-Femenia, P. |
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Title |
Non-relativistic pair annihilation of nearly mass degenerate neutralinos and charginos I. General framework and S-wave annihilation |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
148 - 48pp |
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Keywords |
Cosmology of Theories beyond the SM; Supersymmetric Standard Model; Nonperturbative Effects |
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Abstract |
We compute analytically the tree-level annihilation rates of a collection of non-relativistic neutralino and chargino two-particle states in the general MSSM, including the previously unknown off-diagonal rates. The results are prerequisites to the calculation of the Sommerfeld enhancement in the MSSM, which will be presented in subsequent work. They can also be used to obtain concise analytic expressions for MSSM dark matter pair annihilation in the present Universe for a large number of exclusive two-particle final states. |
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Address |
Tech Univ Munich, Phys Dept T31, D-85748 Garching, Germany, Email: mbeneke@physik.rwth-aachen.de; |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000317522400060 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1437 |
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| Permanent link to this record |
