Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Breso-Pla, V., Falkowski, A., & Gonzalez-Alonso, M. (2021). A(FB) in the SMEFT: precision Z physics at the LHC. J. High Energy Phys., 08(8), 021–27pp.
Abstract: We study the forward-backward asymmetry A(FB) in pp -> l(+)l(-) at the Z peak within the Standard Model Effective Field Theory (SMEFT). We find that this observable provides per mille level constraints on the vertex corrections of the Z boson to quarks, which close a flat direction in the electroweak precision SMEFT fit. Moreover, we show that current A(FB) data is precise enough so that its inclusion in the fit improves significantly LEP bounds even in simple New Physics setups. This demonstrates that the LHC can compete with and complement LEP when it comes to precision measurements of the Z boson properties.
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ATLAS Collaboration(Aad, G. et al), Aparisi Pozo, J. A., Bailey, A. J., Cabrera Urban, S., Cardillo, F., Castillo, F. L., et al. (2021). Determination of the parton distribution functions of the proton from ATLAS measurements of differential W-+/- and Z boson production in association with jets. J. High Energy Phys., 07(7), 223–44pp.
Abstract: This article presents a new set of proton parton distribution functions, AT-LASepWZVjet20, produced in an analysis at next-to-next-to-leading order in QCD. The new data sets considered are the measurements of W+ and W- boson and Z boson production in association with jets in pp collisions at root s = 8 TeV performed by the ATLAS experiment at the LHC with integrated luminosities of 20.2 fb(-1) and 19.9 fb(-1), respectively. The analysis also considers the ATLAS measurements of differential W-+/- and Z boson production at root s = 7 TeV with an integrated luminosity of 4.6 fb(-1) and deep-inelastic-scattering data from e(+/-) p collisions at the HERA accelerator. An improved determination of the sea-quark densities at high Bjorken x is shown, while confirming a strange-quark density similar in size to the up- and down-sea-quark densities in the range x less than or similar to 0.02 found by previous ATLAS analyses.
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ATLAS Collaboration(Aaboud, M. et al), Alvarez Piqueras, D., Aparisi Pozo, J. A., Bailey, A. J., Cabrera Urban, S., Castillo, F. L., et al. (2021). Measurement of single top-quark production in association with a W boson in the single-lepton channel at root s=8 TeV with the ATLAS detector. Eur. Phys. J. C, 81(8), 720–29pp.
Abstract: The production cross-section of a top quark in association with a W boson is measured using proton-proton collisions at root s = 8 TeV. The dataset corresponds to an integrated luminosity of 20.2 fb(-1,) and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant t (t) over bar background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured crosssection is sigma(tW) = 26 +/- 7 pb, in good agreement with the Standard Model expectation.
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Alves, J. M., Botella, F. J., Branco, G. C., Cornet-Gomez, F., & Nebot, M. (2021). The framework for a common origin of delta(CKM) and delta S-PMN. Eur. Phys. J. C, 81(8), 727–11pp.
Abstract: We analyse a possible connection between CP violations in the quark and lepton sectors, parametrised by the CKM and PMNS phases. If one assumes that CP breaking arises from complexYukawa couplings, both in the quark and lepton sectors, the above connection is not possible in general, sinceYukawa couplings in the two sectors have independent flavour structures. We show that both the CKM and PMNS phases can instead be generated by a vacuum phase in a class of two Higgs doublet models, and in this case a connection may be established. This scenario requires the presence of scalar FCNC at tree level, both in the quark and lepton sectors. The appearance of these FCNC is an obstacle and a blessing. An obstacle since one has to analyse which models are able to conform to the strict experimental limits on FCNC, both in the quark and lepton sectors. A blessing, because this class of models is falsifiable since FCNC arise at a level which can be probed experimentally in the near future, specially in the processes h up arrow e(+/-) t +/- and t -> hc. The connection between CP violations in CKM and PMNS is explicitely illustrated in models with Minimal Flavour Violation.
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