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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Jin, S. Y. et al, & Algora, A. (2021). Spectroscopy of Cd-98 by two-nucleon removal from In-100. Phys. Rev. C, 104(2), 024302–6pp.
Abstract: Low-lying states of Cd-98 have been populated by the two-nucleon removal reaction (In-100, Cd-98+gamma) and studied using in-beam gamma-ray spectroscopy at the Radioactive Isotope Beam Factory at RIKEN. Two new gamma transitions were identified and assigned as decays from a previously unknown state. This state is suggested to be based on a pi 1g(/9/2)(-1)2p(1/2)(-2) configuration with J(pi) = 5(-). The present observation extends the systematics of the excitation energies of the first 5(-) state in N = 50 isotones toward Sn-100. The determined energy of the 5(- )state in Cd-98 continues a smooth trend along the N = 50 isotones. The systematics are compared with shell-model calculations in different model spaces. Good agreement is achieved when considering a model space consisting of the pi(1f(5/2), 2p(3/2), 2p(1/2), 1g(9/2)) orbitals. The calculations with a smaller model space omitting the orbitals below the Z = 38 subshell could not reproduce the experimental energy difference between the ground and first 5(-) states in N = 50 isotones, because proton excitations across Z = 38 subshell yield a large amount of correlation energy that lowers the ground states.
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HAWC and HESS Collaborations(Abdalla, H. et al), & Salesa Greus, F. (2021). TeV Emission of Galactic Plane Sources with HAWC and HESS. Astrophys. J., 917(1), 6–16pp.
Abstract: The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy gamma-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view, and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both data sets, the point-spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the gamma-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. data set. Remaining differences in the overall gamma-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the gamma-ray sky between WCD and IACT techniques.
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Di Valentino, E., Mena, O., Pan, S., Visinelli, L., Yang, W. Q., Melchiorri, A., et al. (2021). In the realm of the Hubble tension – a review of solutions. Class. Quantum Gravity, 38(15), 153001–110pp.
Abstract: The simplest ΛCDM model provides a good fit to a large span of cosmological data but harbors large areas of phenomenology and ignorance. With the improvement of the number and the accuracy of observations, discrepancies among key cosmological parameters of the model have emerged. The most statistically significant tension is the 4 sigma to 6 sigma disagreement between predictions of the Hubble constant, H (0), made by the early time probes in concert with the 'vanilla' ΛCDM cosmological model, and a number of late time, model-independent determinations of H (0) from local measurements of distances and redshifts. The high precision and consistency of the data at both ends present strong challenges to the possible solution space and demands a hypothesis with enough rigor to explain multiple observations-whether these invoke new physics, unexpected large-scale structures or multiple, unrelated errors. A thorough review of the problem including a discussion of recent Hubble constant estimates and a summary of the proposed theoretical solutions is presented here. We include more than 1000 references, indicating that the interest in this area has grown considerably just during the last few years. We classify the many proposals to resolve the tension in these categories: early dark energy, late dark energy, dark energy models with 6 degrees of freedom and their extensions, models with extra relativistic degrees of freedom, models with extra interactions, unified cosmologies, modified gravity, inflationary models, modified recombination history, physics of the critical phenomena, and alternative proposals. Some are formally successful, improving the fit to the data in light of their additional degrees of freedom, restoring agreement within 1-2 sigma between Planck 2018, using the cosmic microwave background power spectra data, baryon acoustic oscillations, Pantheon SN data, and R20, the latest SH0ES Team Riess, et al (2021 Astrophys. J. 908 L6) measurement of the Hubble constant (H (0) = 73.2 +/- 1.3 km s(-1) Mpc(-1) at 68% confidence level). However, there are many more unsuccessful models which leave the discrepancy well above the 3 sigma disagreement level. In many cases, reduced tension comes not simply from a change in the value of H (0) but also due to an increase in its uncertainty due to degeneracy with additional physics, complicating the picture and pointing to the need for additional probes. While no specific proposal makes a strong case for being highly likely or far better than all others, solutions involving early or dynamical dark energy, neutrino interactions, interacting cosmologies, primordial magnetic fields, and modified gravity provide the best options until a better alternative comes along.
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Arbelaez, C., Dib, C., Monsalvez-Pozo, K., & Schmidt, I. (2021). Quasi-Dirac neutrinos in the linear seesaw model. J. High Energy Phys., 07(7), 154–22pp.
Abstract: We implement a minimal linear seesaw model (LSM) for addressing the Quasi-Dirac (QD) behaviour of heavy neutrinos, focusing on the mass regime of M-N less than or similar to M-W. Here we show that for relatively low neutrino masses, covering the few GeV range, the same-sign to opposite-sign dilepton ratio, R-ll, can be anywhere between 0 and 1, thus signaling a Quasi-Dirac regime. Particular values of R-ll are controlled by the width of the QD neutrino and its mass splitting, the latter being equal to the light-neutrino mass m(nu) in the LSM scenario. The current upper bound on m(nu 1) together with the projected sensitivities of current and future |U-N l|(2) experimental measurements, set stringent constraints on our low-scale QD mass regime. Some experimental prospects of testing the model by LHC displaced vertex searches are also discussed.
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