Abstract: BackgroundNon-melanoma skin cancer is one of the most common types of cancer and one of the main approaches is brachytherapy. For small lesions, the treatment of this cancer with brachytherapy can be done with two commercial applicators, one of these is the Large Field Valencia Applicators (LFVA).PurposeThe aim of this study is to test the capabilities of the LFVA to use clinically 60Co sources instead of the 192Ir ones. This study was designed for the same dwell positions and weights for both sources.MethodsThe Penelope Monte Carlo code was used to evaluate dose distribution in a water phantom when a 60Co source is considered. The LFVA design and the optimized dwell weights reported for the case of 192Ir are maintained with the only exception of the dwell weight of the central position, that was increased. 2D dose distributions, field flatness, symmetry and the leakage dose distribution around the applicator were calculated.ResultsWhen comparing the dose distributions of both sources, field flatness and symmetry remain unchanged. The only evident difference is an increase of the penumbra regions for all depths when using the 60Co source. Regarding leakage, the maximum dose within the air volume surrounding the applicator is in the order of 20% of the prescription dose for the 60Co source, but it decreases to less than 5% at about 1 cm distance.ConclusionsFlatness and symmetry remains unaltered as compared with 192Ir sources, while an increase in leakage has been observed. This proves the feasibility of using the LFVA in a larger range of clinical applications.

Abstract: We present the results of a missing-energy search for light dark matter which has a new interaction with ordinary matter transmitted by a vector boson, called dark photon A'. For the first time, this search is performed with a positron beam by using the significantly enhanced production of A' in the resonant annihilation of positrons with atomic electrons of the target nuclei, followed by the invisible decay of A' into dark matter. No events were found in the signal region with (10.1 +/- 0.1) x 109 positrons on target with 100 GeV energy. This allowed us to set new exclusion limits that, relative to the collected statistics, prove the power of this experimental technique. This measurement is a crucial first step toward a future exploration program with positron beams, whose estimated sensitivity is here presented.

Abstract: The production rate of B-s(0) mesons relative to B-0 mesons is measured by the LHCb experiment in pp collisions at a center-of-mass energy root s = 13 TeV over the forward rapidity interval 2 < y < 4.5 as a function of the charged particle multiplicity measured in the event. Evidence at the 3.4 sigma level is found for an increase of the ratio of B-s(0) to B-0 cross sections with multiplicity at transverse momenta below 6 GeV=c, with no significant multiplicity dependence at higher transverse momentum. Comparison with data from e(+)e(-) collisions implies that the density of the hadronic medium may affect the production rates of B mesons. This is qualitatively consistent with the emergence of quark coalescence as an additional hadronization mechanism in high-multiplicity collisions.

Abstract: This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at the LHC, using 139 fb(-1) of data collected with the ATLAS detector at a centre-of-mass energy of 13 TeV. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs boson is produced according to the StandardModel in associationwith a pair of top quarks. For scalar (pseudoscalar) dark matter models, with all couplings set to unity, the statistical combination extends the mass range excluded by the best of the individual channels by 50 (25) GeV, excluding mediator masses up to 370 GeV. In addition, the statistical combination improves the expected coupling exclusion reach by 14% (24%), assuming a scalar (pseudoscalar) mediator mass of 10 GeV. An upper limit on the Higgs boson invisible branching ratio of 0.38 (0.30(-0.09)(+0.13)) is observed (expected) at 95% confidence level.

Abstract: This paper reports a search for Higgs boson pair (hh) production in association with a vector boson ( W or Z) using 139 fb(-1) of proton-proton collision data at root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The search is performed in final states in which the vector boson decays leptonically (W -> l nu, Z -> ll, nu nu with l = e, mu) and the Higgs bosons each decay into a pair of b-quarks. It targets Vhh signals from both non-resonant hh production, present in the Standard Model (SM), and resonant hh production, as predicted in some SM extensions. A 95% confidence-level upper limit of 183 (87) times the SM cross-section is observed (expected) for non-resonant Vhh production when assuming the kinematics are as expected in the SM. Constraints are also placed on Higgs boson coupling modifiers. For the resonant search, upper limits on the production cross-sections are derived for two specific models: one is the production of a vector boson along with a neutral heavy scalar resonance H, in the mass range 260-1000GeV, that decays into hh, and the other is the production of a heavier neutral pseudoscalar resonance A that decays into a Z boson and H boson, where the A boson mass is 360-800GeV and the H boson mass is 260-400GeV. Constraints are also derived in the parameter space of two-Higgs-doublet models.