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Oliver-Cañamas, L.; Rovira-Escutia, J.J.; Vijande, J.; Candela-Juan, C.; Gimeno-Olmos, J.; Pujades-Claumarchirant, M.C.; Martinez-Navarro, J.A.; Zaragozá-Carrillo, A.; Garcia-Cases, F.; Ballester, F.; Perez-Calatayud, J. |
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Title |
A system for mailed dosimetric audits of 192 Ir and 60 Co HDR brachytherapy combining OSLD and radiochromic film |
Type |
Journal Article |
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Year |
2024 |
Publication |
Radiation Measurements |
Abbreviated Journal |
Radiat. Meas. |
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Volume |
173 |
Issue |
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Pages |
107101 - 8pp |
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Address |
[Oliver-Canamas, Laura] Consorci Hosp Prov Castello CHPC, Serv Radiofis & Proteccio Radiol, Castellon De La Plana 12002, Spain, Email: laura.oliver.canas@gmail.com |
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Pergamon-Elsevier Science Ltd |
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English |
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ISSN |
1350-4487 |
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Notes |
WOS:001300927300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6241 |
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Author |
Martins, A.; da Mota, A.F.; Stanford, C.; Contreras, T.; Martin-Albo, J.; Kish, A.; Escobar, C.O.; Para, A.; Guenette, R. |
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Title |
Simple strategy for the simulation of axially symmetric large-area metasurfaces |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of the Optical Society of America B |
Abbreviated Journal |
J. Opt. Soc. Am. B |
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Volume |
41 |
Issue |
5 |
Pages |
1261-1269 |
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Abstract |
Metalenses are composed of nanostructures for focusing light and have been widely explored in many exciting applications. However, their expanding dimensions pose simulation challenges. We propose a method to simulate metalenses in a timely manner using vectorial wave and ray tracing models. We sample the metalens's radial phase gradient and locally approximate the phase profile by a linear phase response. Each sampling point is modeled as a binary blazed grating, employing the chosen nanostructure, to build a transfer function set. The metalens transmission or reflection is then obtained by applying the corresponding transfer function to the incoming field on the regions surrounding each sampling point. Fourier optics is used to calculate the scattered fields under arbitrary illumination for the vectorial wave method, and a Monte Carlo algorithm is used in the ray tracing formalism. We validated our method against finite -difference time domain simulations at 632 nm, and we were able to simulate metalenses larger than 3000 wavelengths in diameter on a personal computer. |
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Address |
[Martins, Augusto; Guenette, Roxanne] Univ Manchester, Dept Phys, Manchester M13 9PL, England, Email: augusto.martins@york.ac.uk |
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Optica Publishing Group |
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English |
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ISSN |
0740-3224 |
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Notes |
WOS:001237140900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6140 |
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Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Corporate Author |
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Thesis |
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Publisher |
Nature Portfolio |
Place of Publication |
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English |
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Series Volume |
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Edition |
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ISSN |
2045-2322 |
ISBN |
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Conference |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
Ureña, J.; Sojo, A.; Bermejo-Vega, J.; Manzano, D. |
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Title |
Entanglement detection with classical deep neural networks |
Type |
Journal Article |
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Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
18109 - 11pp |
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Keywords |
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Abstract |
In this study, we introduce an autonomous method for addressing the detection and classification of quantum entanglement, a core element of quantum mechanics that has yet to be fully understood. We employ a multi-layer perceptron to effectively identify entanglement in both two- and three-qubit systems. Our technique yields impressive detection results, achieving nearly perfect accuracy for two-qubit systems and over 90% accuracy for three-qubit systems. Additionally, our approach successfully categorizes three-qubit entangled states into distinct groups with a success rate of up to 77%. These findings indicate the potential for our method to be applied to larger systems, paving the way for advancements in quantum information processing applications. |
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Address |
[Urena, Julio] CSIC, Inst Fis Corpuscular IF, Valencia 46980, Spain, Email: manzano@onsager.ugr.es |
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Nature Portfolio |
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English |
Summary Language |
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ISSN |
2045-2322 |
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Notes |
WOS:001284942100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6230 |
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Author |
Balbinot, R.; Fabbri, A. |
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Title |
The Unruh Vacuum and the “In-Vacuum” in Reissner-Nordström Spacetime |
Type |
Journal Article |
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Year |
2024 |
Publication |
Universe |
Abbreviated Journal |
Universe |
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Volume |
10 |
Issue |
1 |
Pages |
18 - 14pp |
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Keywords |
Hawking radiation; Unruh vacuum; Reissner-Nordstrom black holes |
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Abstract |
The Unruh vacuum is widely used as a quantum state to describe black hole evaporation since, near the horizon, it reproduces the physical state of a quantum field, the so-called “in-vacuum”, in the case where a black hole is formed by gravitational collapse. We examine the relation between these two quantum states in the background spacetime of a Reissner-Nordstrom black hole (both extremal and not), highlighting the similarities and striking differences. |
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Address |
[Balbinot, Roberto] Univ Bologna, Dipartimento Fis, Via Irnerio 46, I-40126 Bologna, Italy, Email: roberto.balbinot@unibo.it; |
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Mdpi |
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English |
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Conference |
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Notes |
WOS:001151025300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5914 |
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Author |
Real, D.; Calvo, D.; Zornoza, J.D.; Manzaneda, M.; Gozzini, R.; Ricolfe-Viala, C.; Lajara, R.; Albiol, F. |
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Title |
Fast Coincidence Filter for Silicon Photomultiplier Dark Count Rate Rejection |
Type |
Journal Article |
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Year |
2024 |
Publication |
Sensors |
Abbreviated Journal |
Sensors |
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Volume |
24 |
Issue |
7 |
Pages |
2084 - 12pp |
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Keywords |
time-to-digital converters; neutrino telescopes; silicon photomultipliers; dark noise rate filtering |
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Abstract |
Silicon Photomultipliers find applications across various fields. One potential Silicon Photomultiplier application domain is neutrino telescopes, where they may enhance the angular resolution. However, the elevated dark count rate associated with Silicon Photomultipliers represents a significant challenge to their widespread utilization. To address this issue, it is proposed to use Silicon Photomultipliers and Photomultiplier Tubes together. The Photomultiplier Tube signals serve as a trigger to mitigate the dark count rate, thereby preventing undue saturation of the available bandwidth. This paper presents an investigation into a fast and resource-efficient method for filtering the Silicon Photomultiplier dark count rate. A low-resource and fast coincident filter has been developed, which removes the Silicon Photomultiplier dark count rate by using as a trigger the Photomultiplier Tube input signals. The architecture of the coincidence filter, together with the first results obtained, which validate the effectiveness of this method, is presented. |
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Address |
[Real, Diego; Calvo, David; Zornoza, Juan de Dios; Manzaneda, Mario; Gozzini, Rebecca; Albiol, Francisco] CSIC Univ Valencia, IFIC Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: real@ific.uv.es; |
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Mdpi |
Place of Publication |
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English |
Summary Language |
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Series Editor |
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Conference |
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Notes |
WOS:001201226600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6063 |
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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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Notes |
WOS:001269841000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Maluf, R.V.; Mora-Perez, G.; Olmo, G.J.; Rubiera-Garcia, D. |
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Title |
Nonsingular, Lump-like, Scalar Compact Objects in (2+1)-Dimensional Einstein Gravity |
Type |
Journal Article |
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Year |
2024 |
Publication |
Universe |
Abbreviated Journal |
Universe |
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Volume |
10 |
Issue |
6 |
Pages |
258 - 13pp |
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Keywords |
Einstein gravity; compact objects; nonlinear scalar field |
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Abstract |
We study the space-time geometry generated by coupling a free scalar field with a noncanonical kinetic term to general relativity in (2+1) dimensions. After identifying a family of scalar Lagrangians that yield exact analytical solutions in static and circularly symmetric scenarios, we classify the various types of solutions and focus on a branch that yields asymptotically flat geometries. We show that the solutions within such a branch can be divided in two types, namely naked singularities and nonsingular objects without a center. In the latter, the energy density is localized around a maximum and vanishes only at infinity and at an inner boundary. This boundary has vanishing curvatures and cannot be reached by any time-like or null geodesic in finite affine time. This allows us to consistently interpret such solutions as nonsingular, lump-like, static compact scalar objects whose eventual extension to the (3+1)-dimensional context could provide structures of astrophysical interest. |
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Address |
[Maluf, Roberto V.; Olmo, Gonzalo J.] Univ Fed Ceara UFC, Dept Fis, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil, Email: r.v.maluf@fisica.ufc.br; |
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Mdpi |
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English |
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Notes |
WOS:001256495600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6169 |
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Author |
KM3NeT Collaboration (Aiello, S. et al); Alves Garre, S.; Bariego-Quintana, A.; Calvo, D.; Carretero, V.; Cecchini, V.; Garcia Soto, A.; Gozzini, S.R.; Hernandez-Rey, J.J.; Lazo, A.; Lessing, N.; Manczak, J.; Palacios Gonzalez, J.; Pastor Gomez, E.J.; Prado, J.; Rahaman, U.; Real, D.; Saina, A.; Salesa Greus, F.; Sanchez Losa, A.; Zornoza, J.D.; Zuñiga, J. |
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Title |
The Power Board of the KM3NeT Digital Optical Module: Design, Upgrade, and Production |
Type |
Journal Article |
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Year |
2024 |
Publication |
Electronics |
Abbreviated Journal |
Electronics |
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Volume |
13 |
Issue |
11 |
Pages |
2044 - 17pp |
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Keywords |
power supply; acquisition electronics; neutrino telescopes |
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Abstract |
The KM3NeT Collaboration is building an underwater neutrino observatory at the bottom of the Mediterranean Sea, consisting of two neutrino telescopes, both composed of a three-dimensional array of light detectors, known as digital optical modules. Each digital optical module contains a set of 31 three-inch photomultiplier tubes distributed over the surface of a 0.44 m diameter pressure-resistant glass sphere. The module also includes calibration instruments and electronics for power, readout, and data acquisition. The power board was developed to supply power to all the elements of the digital optical module. The design of the power board began in 2013, and ten prototypes were produced and tested. After an exhaustive validation process in various laboratories within the KM3NeT Collaboration, a mass production batch began, resulting in the construction of over 1200 power boards so far. These boards were integrated in the digital optical modules that have already been produced and deployed, which total 828 as of October 2023. In 2017, an upgrade of the power board, to increase reliability and efficiency, was initiated. The validation of a pre-production series has been completed, and a production batch of 800 upgraded boards is currently underway. This paper describes the design, architecture, upgrade, validation, and production of the power board, including the reliability studies and tests conducted to ensure safe operation at the bottom of the Mediterranean Sea throughout the observatory's lifespan. |
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Address |
[Aiello, Sebastiano; Bruno, Riccardo; Leonora, Emanuele; Longhitano, Fabio; Randazzo, Nunzio; Sinopoulou, Anna; Tosta e Melo, Iara] Ist Nazl Fis Nucl, Sez Catania, Via Santa Sofia 64, I-95123 Catania, Italy, Email: sebastiano.aiello@ct.infn.it; |
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Mdpi |
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English |
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Notes |
WOS:001285365000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6233 |
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Author |
Real, D.; Calvo, D. |
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Title |
Low-Resource Time-to-Digital Converters for Field Programmable Gate Arrays: A Review |
Type |
Journal Article |
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Year |
2024 |
Publication |
Sensors |
Abbreviated Journal |
Sensors |
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Volume |
24 |
Issue |
17 |
Pages |
5512 - 15pp |
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Keywords |
time-to-digital converter; field-programmable gate array; low-resource time-to-digital converters |
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Abstract |
A fundamental aspect in the evolution of Time-to-Digital Converters (TDCs) implemented within Field-Programmable Gate Arrays (FPGAs), given the increasing demand for detection channels, is the optimization of resource utilization. This study reviews the principal methodologies employed for implementing low-resource TDCs in FPGAs. It outlines the foundational architectures and interpolation techniques utilized to bolster TDC performances without unduly burdening resource consumption. Low-resource Tapped Delay Line, Vernier Ring Oscillator, and Multi-Phase Shift Counter TDCs, including the use of SerDes, are reviewed. Additionally, novel low-resource architectures are scrutinized, including Counter Gray Oscillator TDCs and interpolation expansions using Process-Voltage-Temperature stable IODELAYs. Furthermore, the advantages and limitations of each approach are critically assessed, with particular emphasis on resolution, precision, non-linearities, and especially resource utilization. A comprehensive summary table encapsulating existing works on low-resource TDCs is provided, offering a comprehensive overview of the advancements in the field. |
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Address |
[Real, Diego; Calvo, David] Univ Valencia, IFIC Inst Fis Corpuscular, CSIC, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: real@ific.uv.es |
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Mdpi |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
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ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001311766100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6254 |
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| Permanent link to this record |
