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Bernabeu, J. (2020). Symmetries and Their Breaking in the Fundamental Laws of Physics. Symmetry-Basel, 12(8), 1316–27pp.
Abstract: Symmetries in the Physical Laws of Nature lead to observable effects. Beyond the regularities and conserved magnitudes, the last few decades in particle physics have seen the identification of symmetries, and their well-defined breaking, as the guiding principle for the elementary constituents of matter and their interactions. Flavour SU(3) symmetry of hadrons led to the Quark Model and the antisymmetric requirement under exchange of identical fermions led to the colour degree of freedom. Colour became the generating charge for flavour-independent strong interactions of quarks and gluons in the exact colour SU(3) local gauge symmetry. Parity Violation in weak interactions led us to consider the chiral fields of fermions as the objects with definite transformation properties under the weak isospin SU(2) gauge group of the Unifying Electro-Weak SU(2) x U(1) symmetry, which predicted novel weak neutral current interactions. CP-Violation led to three families of quarks opening the field of Flavour Physics. Time-reversal violation has recently been observed with entangled neutral mesons, compatible with CPT-invariance. The cancellation of gauge anomalies, which would invalidate the gauge symmetry of the quantum field theory, led to Quark-Lepton Symmetry. Neutrinos were postulated in order to save the conservation laws of energy and angular momentum in nuclear beta decay. After the ups and downs of their mass, neutrino oscillations were discovered in 1998, opening a new era about their origin of mass, mixing, discrete symmetries and the possibility of global lepton-number violation through Majorana mass terms and Leptogenesis as the source of the matter-antimatter asymmetry in the universe. The experimental discovery of quarks and leptons and the mediators of their interactions, with physical observables in spectacular agreement with this Standard Theory, is the triumph of Symmetries. The gauge symmetry is exact only when the particles are massless. One needs a subtle breaking of the symmetry, providing the origin of mass without affecting the excellent description of the interactions. This is the Brout-Englert-Higgs Mechanism, which produces the Higgs Boson as a remnant, discovered at CERN in 2012. Open present problems are addressed with by searching the New Physics Beyond-the-Standard-Model.
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Moretti, F., Bombacigno, F., & Montani, G. (2021). The Role of Longitudinal Polarizations in Horndeski and Macroscopic Gravity: Introducing Gravitational Plasmas. Universe, 7(12), 496–28pp.
Abstract: We discuss some general and relevant features of longitudinal gravitational modes in Horndeski gravity and their interaction with matter media. Adopting a gauge-invariant formulation, we clarify how massive scalar and vector fields can induce additional transverse and longitudinal excitations, resulting in breathing, vector, and longitudinal polarizations. We review, then, the interaction of standard gravitational waves with a molecular medium, outlining the emergence of effective massive gravitons, induced by the net quadrupole moment due to molecule deformation. Finally, we investigate the interaction of the massive mode in Horndeski gravity with a noncollisional medium, showing that Landau damping phenomenon can occur in the gravitational sector as well. That allows us to introduce the concept of “gravitational plasma”, where inertial forces associated with the background field play the role of cold ions in electromagnetic plasma.
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Ferreira, M. N., & Papavassiliou, J. (2023). Gauge Sector Dynamics in QCD. Particles, 6(1), 312–363.
Abstract: The dynamics of the QCD gauge sector give rise to non-perturbative phenomena that are crucial for the internal consistency of the theory; most notably, they account for the generation of a gluon mass through the action of the Schwinger mechanism, the taming of the Landau pole, the ensuing stabilization of the gauge coupling, and the infrared suppression of the three-gluon vertex. In the present work, we review some key advances in the ongoing investigation of this sector within the framework of the continuum Schwinger function methods, supplemented by results obtained from lattice simulations.
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Van Isacker, P., Algora, A., Vitéz-Sveiczer, A., Kiss, G. G., Orrigo, S. E. A., Rubio, B., et al. (2023). Gamow-Teller Beta Decay and Pseudo-SU(4) Symmetry. Symmetry-Basel, 15(11), 2001–15pp.
Abstract: We report on recent experimental results on beta decay into self-conjugate ( N = Z) nuclei with mass number 58 <= A <= 70. Super-allowed b decays from the J(pi) = 0(+) ground state of a Z = N + 2 parent nucleus are to the isobaric analogue state through so-called Fermi transitions and to J(pi) = 1(+) states by way of Gamow-Teller (GT) transitions. The operator of the latter decay is a generator of Wigner's SU(4) algebra and as a consequence GT transitions obey selection rules associated with this symmetry. Since SU(4) is progressively broken with increasing A, mainly as a consequence of the spinorbit interaction, this symmetry is not relevant for the nuclei considered here. We argue, however, that the pseudo-spin-orbit splitting can be small in nuclei with 58 <= A <= 70, in which case nuclear states exhibit an approximate pseudo-SU(4) symmetry. To test this conjecture, GT decay strength is calculated with use of a schematic Hamiltonian with pseudo-SU(4) symmetry. Some generic features of the GT beta decay due to pseudo-SU(4) symmetry are pointed out. The experimentally observed GT strength indicates a restoration of pseudo-SU(4) symmetry for A = 70.
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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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