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Babak, S., Caprini, C., Figueroa, D. G., Karnesis, N., Marcoccia, P., Nardini, G., et al. (2023). Stochastic gravitational wave background from stellar origin binary black holes in LISA. J. Cosmol. Astropart. Phys., 08(8), 034–40pp.
Abstract: We use the latest constraints on the population of stellar origin binary black holes (SOBBH) from LIGO/Virgo/KAGRA (LVK) observations, to estimate the stochastic gravi-tational wave background (SGWB) they generate in the frequency band of LISA. In order to account for the faint and distant binaries, which contribute the most to the SGWB, we extend the merger rate at high redshift assuming that it tracks the star formation rate. We adopt different methods to compute the SGWB signal: we perform an analytical evaluation, we use Monte Carlo sums over the SOBBH population realisations, and we account for the role of the detector by simulating LISA data and iteratively removing the resolvable signals until only the confusion noise is left. The last method allows the extraction of both the expected SGWB and the number of resolvable SOBBHs. Since the latter are few for signal-to-noise ratio thresholds larger than five, we confirm that the spectral shape of the SGWB in the LISA band agrees with the analytical prediction of a single power law. We infer the probability dis-tribution of the SGWB amplitude from the LVK GWTC-3 posterior of the binary population model: at the reference frequency of 0.003 Hz it has an interquartile range of h(2 Omega)GW(f = 3 x 10(-3) Hz) is an element of [5.65, 11.5] x 10(-13), in agreement with most previous estimates. We then perform a MC analysis to assess LISA's capability to detect and characterise this signal. Ac-counting for both the instrumental noise and the galactic binaries foreground, with four years of data, LISA will be able to detect the SOBBH SGWB with percent accuracy, narrowing down the uncertainty on the amplitude by one order of magnitude with respect to the range of possible amplitudes inferred from the population model. A measurement of this signal by LISA will help to break the degeneracy among some of the population parameters, and pro-vide interesting constraints, in particular on the redshift evolution of the SOBBH merger rate.
Keywords: gravitational waves; experiments; sources
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Forconi, M., Giare, W., Mena, O., Ruchika, Di Valentino, E., Melchiorri, A., et al. (2024). A double take on early and interacting dark energy from JWST. J. Cosmol. Astropart. Phys., 05(5), 097–37pp.
Abstract: The very first light captured by the James Webb Space Telescope (JWST) revealed a population of galaxies at very high redshifts more massive than expected in the canonical Lambda CDM model of structure formation. Barring, among others, a systematic origin of the issue, in this paper, we test alternative cosmological perturbation histories. We argue that models with a larger matter component ohm m and/or a larger scalar spectral index n s can substantially improve the fit to JWST measurements. In this regard, phenomenological extensions related to the dark energy sector of the theory are appealing alternatives, with Early Dark Energy emerging as an excellent candidate to explain (at least in part) the unexpected JWST preference for larger stellar mass densities. Conversely, Interacting Dark Energy models, despite producing higher values of matter clustering parameters such as sigma 8 , are generally disfavored by JWST measurements. This is due to the energy -momentum flow from the dark matter to the dark energy sector, implying a smaller matter energy density. Upcoming observations may either strengthen the evidence or falsify some of these appealing phenomenological alternatives to the simplest Lambda CDM picture.
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Agius, D., Essig, R., Gaggero, D., Scarcella, F., Suczewski, G., & Valli, M. (2024). Feedback in the dark: a critical examination of CMB bounds on primordial black holes. J. Cosmol. Astropart. Phys., 07(7), 003–36pp.
Abstract: If present in the early universe, primordial black holes (PBHs) would have accreted matter and emitted high-energy photons, altering the statistical properties of the Cosmic Microwave Background (CMB). This mechanism has been used to constrain the fraction of dark matter that is in the form of PBHs to be much smaller than unity for PBH masses well above one solar mass. Moreover, the presence of dense dark matter mini -halos around the PBHs has been used to set even more stringent constraints, as these would boost the accretion rates. In this work, we critically revisit CMB constraints on PBHs taking into account the role of the local ionization of the gas around them. We discuss how the local increase in temperature around PBHs can prevent the dark matter mini -halos from strongly enhancing the accretion process, in some cases significantly weakening previously derived CMB constraints. We explore in detail the key ingredients of the CMB bound and derive a conservative limit on the cosmological abundance of massive PBHs.
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Magalhaes, R. B., Ribeiro, G. P., Lima, H. C. D. J., Olmo, G. J., & Crispino, L. C. B. (2024). Singular space-times with bounded algebraic curvature scalars. J. Cosmol. Astropart. Phys., 05(5), 114–34pp.
Abstract: We show that the absence of unbounded algebraic curvature invariants constructed from polynomials of the Riemann tensor cannot guarantee the absence of strong singularities. As a consequence, it is not sufficient to rely solely on the analysis of such scalars to assess the regularity of a given space-time. This conclusion follows from the analysis of incomplete geodesics within the internal region of asymmetric wormholes supported by scalar matter which arise in two distinct metric-affine gravity theories. These wormholes have bounded algebraic curvature scalars everywhere, which highlights that their finiteness does not prevent the emergence of pathologies (singularities) in the geodesic structure of space-time. By analyzing the tidal forces in the internal wormhole region, we find that the angular components are unbounded along incomplete radial time-like geodesics. The strength of the singularity is determined by the evolution of Jacobi fields along such geodesics, finding that it is of strong type, as volume elements are torn apart as the singularity is approached. Lastly, and for completeness, we consider the wormhole of the quadratic Palatini theory and present an analysis of the tidal forces in the entire space-time.
Keywords: gravity; modified gravity; Wormholes
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Sorelli, G., Gessner, M., Treps, N., & Walschaers, M. (2024). Gaussian quantum metrology for mode-encoded parameters. New J. Phys., 26(7), 073022–23pp.
Abstract: Quantum optical metrology aims to identify ultimate sensitivity bounds for the estimation of parameters encoded into quantum states of the electromagnetic field. In many practical applications, including imaging, microscopy, and remote sensing, the parameter of interest is not only encoded in the quantum state of the field, but also in its spatio-temporal distribution, i.e. in its mode structure. In this mode-encoded parameter estimation setting, we derive an analytical expression for the quantum Fisher information valid for arbitrary multimode Gaussian fields. To illustrate the power of our approach, we apply our results to the estimation of the transverse displacement of a beam and to the temporal separation between two pulses. For these examples, we show how the estimation sensitivity can be enhanced by adding squeezing into specific modes.
Keywords: quantum metrology; multimode quantum optics; Gaussian states
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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Maluf, R. V., Mora-Perez, G., Olmo, G. J., & Rubiera-Garcia, D. (2024). Nonsingular, Lump-like, Scalar Compact Objects in (2+1)-Dimensional Einstein Gravity. Universe, 10(6), 258–13pp.
Abstract: We study the space-time geometry generated by coupling a free scalar field with a noncanonical kinetic term to general relativity in (2+1) dimensions. After identifying a family of scalar Lagrangians that yield exact analytical solutions in static and circularly symmetric scenarios, we classify the various types of solutions and focus on a branch that yields asymptotically flat geometries. We show that the solutions within such a branch can be divided in two types, namely naked singularities and nonsingular objects without a center. In the latter, the energy density is localized around a maximum and vanishes only at infinity and at an inner boundary. This boundary has vanishing curvatures and cannot be reached by any time-like or null geodesic in finite affine time. This allows us to consistently interpret such solutions as nonsingular, lump-like, static compact scalar objects whose eventual extension to the (3+1)-dimensional context could provide structures of astrophysical interest.
Keywords: Einstein gravity; compact objects; nonlinear scalar field
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Penas, J., Alejo, A., Bembibre, A., Apiñaniz, J. I., Garcia-Garcia, E., Guerrero, C., et al. (2024). Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source. Sci Rep, 14(1), 11448–12pp.
Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
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Martins, A., da Mota, A. F., Stanford, C., Contreras, T., Martin-Albo, J., Kish, A., et al. (2024). Simple strategy for the simulation of axially symmetric large-area metasurfaces. J. Opt. Soc. Am. B, 41(5), 1261–1269.
Abstract: Metalenses are composed of nanostructures for focusing light and have been widely explored in many exciting applications. However, their expanding dimensions pose simulation challenges. We propose a method to simulate metalenses in a timely manner using vectorial wave and ray tracing models. We sample the metalens's radial phase gradient and locally approximate the phase profile by a linear phase response. Each sampling point is modeled as a binary blazed grating, employing the chosen nanostructure, to build a transfer function set. The metalens transmission or reflection is then obtained by applying the corresponding transfer function to the incoming field on the regions surrounding each sampling point. Fourier optics is used to calculate the scattered fields under arbitrary illumination for the vectorial wave method, and a Monte Carlo algorithm is used in the ray tracing formalism. We validated our method against finite -difference time domain simulations at 632 nm, and we were able to simulate metalenses larger than 3000 wavelengths in diameter on a personal computer.
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ATLAS Collaboration(Aad, G. et al), Amoros, G., Bernabeu Verdu, J., Cabrera Urban, S., Castillo Gimenez, V., Costa, M. J., et al. (2010). The ATLAS Inner Detector commissioning and calibration. Eur. Phys. J. C, 70(3), 787–821.
Abstract: The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 μm and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
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