Piersanti, L., Bellini, F., Bini, F., Collamati, F., De Lucia, E., Durante, M., et al. (2014). Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u C-12 beam. Phys. Med. Biol., 59(7), 1857–1872.
Abstract: The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energetic primary beams interacting with homogeneous tissue like target) have already indicated the correlation that exists between the flux of these secondaries coming from the target (e.g. protons and photons) and the position of the primary beam Bragg peak. In this paper, the measurements of charged particle fluxes produced by the interaction of a 220 MeV/u carbon ion beam at GSI, Darmstadt, with a polymethyl methacrylate target are reported. The emission region of protons (p), deuterons (d) and tritons (t) has been characterized using a drift chamber while the particle time-of-flight, used to compute the kinetic energy spectra, was measured with a LYSO scintillator.The energy released in the LYSO crystal was used for particle identification purposes. The measurements were repeated with the setup at 60 degrees and 90 degrees with respect to the primary beam direction. The accuracy on the fragments emission profile reconstruction and its relationship with the Bragg peak position have been studied. Based on the acquired experimental evidence, a method to monitor the dose profile and the position of the Bragg peak inside the target is proposed.
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Ortega, P. G., Torres-Espallardo, I., Cerutti, F., Ferrari, A., Gillam, J. E., Lacasta, C., et al. (2015). Noise evaluation of Compton camera imaging for proton therapy. Phys. Med. Biol., 60(5), 1845–1863.
Abstract: Compton Cameras emerged as an alternative for real-time dose monitoring techniques for Particle Therapy (PT), based on the detection of prompt-gammas. As a consequence of the Compton scattering process, the gamma origin point can be restricted onto the surface of a cone (Compton cone). Through image reconstruction techniques, the distribution of the gamma emitters can be estimated, using cone-surfaces backprojections of the Compton cones through the image space, along with more sophisticated statistical methods to improve the image quality. To calculate the Compton cone required for image reconstruction, either two interactions, the last being photoelectric absorption, or three scatter interactions are needed. Because of the high energy of the photons in PT the first option might not be adequate, as the photon is not absorbed in general. However, the second option is less efficient. That is the reason to resort to spectral reconstructions, where the incoming. energy is considered as a variable in the reconstruction inverse problem. Jointly with prompt gamma, secondary neutrons and scattered photons, not strongly correlated with the dose map, can also reach the imaging detector and produce false events. These events deteriorate the image quality. Also, high intensity beams can produce particle accumulation in the camera, which lead to an increase of random coincidences, meaning events which gather measurements from different incoming particles. The noise scenario is expected to be different if double or triple events are used, and consequently, the reconstructed images can be affected differently by spurious data. The aim of the present work is to study the effect of false events in the reconstructed image, evaluating their impact in the determination of the beam particle ranges. A simulation study that includes misidentified events (neutrons and random coincidences) in the final image of a Compton Telescope for PT monitoring is presented. The complete chain of detection, from the beam particle entering a phantom to the event classification, is simulated using FLUKA. The range determination is later estimated from the reconstructed image obtained from a two and three-event algorithm based on Maximum Likelihood Expectation Maximization. The neutron background and random coincidences due to a therapeutic-like time structure are analyzed for mono-energetic proton beams. The time structure of the beam is included in the simulations, which will affect the rate of particles entering the detector.
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Muñoz, E., Barrio, J., Etxebeste, A., Ortega, P. G., Lacasta, C., Oliver, J. F., et al. (2017). Performance evaluation of MACACO: a multilayer Compton camera. Phys. Med. Biol., 62(18), 7321–7341.
Abstract: Compton imaging devices have been proposed and studied for a wide range of applications. We have developed a Compton camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs), to be used for proton range verification in hadron therapy. In this work, we present the results obtained with our prototype in laboratory tests with radioactive sources and in simulation studies. Images of a Na-22 and an Y-88 radioactive sources have been successfully reconstructed. The full width half maximum of the reconstructed images is below 4 mm for a Na-22 source at a distance of 5 cm.
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Albaladejo, M., Fernandez-Soler, P., Nieves, J., & Ortega, P. G. (2017). Lowest-lying even-parity (B)over-bar(s) mesons: heavy-quark spin-flavor symmetry, chiral dynamics, and constituent quark-model bare masses. Eur. Phys. J. C, 77(3), 170–9pp.
Abstract: The discovery of the D*(s0)(2317) and D-s1(2460) resonances in the charmed-strange meson spectra revealed that formerly successful constituent quark models lose predictability in the vicinity of two-meson thresholds. The emergence of non-negligible effects due to meson loops requires an explicit evaluation of the interplay between Q (q) over bar and (Q (q) over bar)(q (q) over bar) Fock components. In contrast to the c (s) over bar sector, there is no experimental evidence of J(P) = 0(+), 1(+) bottom-strange states yet. Motivated by recent lattice studies, in this work the heavy-quark partners of the D*(s0)(2317) and D-s1(2460) states are analyzed within a heavy meson chiral unitary scheme. As a novelty, the coupling between the constituent quark-model P-wave (B) over bar (s) scalar and axial mesons and the (B) over bar (()*()) K channels is incorporated employing an effective interaction, consistent with heavy-quark spin symmetry, constrained by the lattice energy levels.
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Albaladejo, M., Fernandez-Soler, P., Nieves, J., & Ortega, P. G. (2018). Contribution of constituent quark model c(s)over-bar states to the dynamics of the D*s0 (2317) and Ds1(2460) resonances. Eur. Phys. J. C, 78(9), 722–22pp.
Abstract: The masses of the D*(s0) (2317) and D-s1(2460) resonances lie below the DK and D* K thresholds respectively, which contradicts the predictions of naive quark models and points out to non-negligible effects of the D(*) K loops in the dynamics of the even-parity scalar (J(pi) = 0(+)) and axial-vector (J(pi) = 1(+)) c (s) over bar systems. Recent lattice QCD studies, incorporating the effects of the D(*) K channels, analyzed these spin-parity sectors and correctly described the D*(s0)(2317) – D-s1(2460) mass splitting. Motivated by such works, we study the structure of the D*(s0)(2317) and D-s1(2460) resonances in the framework of an effective field theory consistent with heavy quark spin symmetry, and that incorporates the interplay between D(*) K meson-meson degrees of freedom and bare P-wave c (s) over bar states predicted by constituent quark models. We extend the scheme to finite volumes and fit the strength of the coupling between both types of degrees of freedom to the available lattice levels, which we successfully describe. We finally estimate the size of the D(*) K two-meson components in the D*(s0)(2317) and D-s1(2460) resonances, and we conclude that these states have a predominantly hadronic-molecular structure, and that it should not be tried to accommodate these mesons within c (s) over bar constituent quark model patterns.
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