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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Study of eta-eta ' mixing from measurement of B-(s)(0) -> J/psi eta((')) decay rates |
Type |
Journal Article |
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Year |
2015 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
01 |
Issue |
1 |
Pages |
024 - 24pp |
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Keywords |
Spectroscopy; Hadron-Hadron Scattering; QCD; Branching fraction; B physics |
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Abstract |
A study of B and B-s(0) meson decays into J/psi eta and J/psi eta' final states is performed using a data set of proton-proton collisions at centre-of-mass energies of 7 and 8 TeV, collected by the LCHb experiment and corresponding to 3.0 fb(-1) of integrated luminosity. The decay B-0 -> J/psi eta' is observed for the first time. The following ratios of branching fractions are measured: B(B-0 -> J psi eta')/B(B-s(0) -> J psi eta') = (2.28 +/- 0.65 (stat) +/- 0.010 (syst) +/- 0.13 (f(s)/f(d)) x 10(-2) , B(B-0 -> J psi eta')/B(B-s(0) -> J psi eta') = (1.85 +/- 0.65 (stat) +/- 0.09 (syst) +/- 0.11 (f(s)/f(d)) x 10(-2) where the third uncertainty is related to the present knowledge of f(s)/f(d), the ratio between the probabilities for a b quark to form a B-s(0) or a B-0 meson. The branching fraction ratios are used to determine the parameters of eta-eta' meson mixing. In addition, the first evidence for the decay B-s(0) -> psi(2S)' is reported, and the relative branching fraction is measured, B(B-s(0) -> psi(2S)eta')/B(B-s(0) -> J psi eta') = (38.7 +/- 9.0 (stat) +/- 1.3 (syst) +/- 0.9(B)) x 10(-2), where the third uncertainty is due to the limited knowledge of the branching fractions of J/psi and psi(2S) mesons. |
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[Bediaga, I.; Miranda, J. M. De; Ferreira Rodrigues, F.; Gomes, A.; Marchand, J. F.; Massafferri, A.; Reis, A. C. dos; Rodrigues, A. B.] CBPF, Rio De Janeiro, Brazil, Email: Ivan.Belyaev@itep.ru |
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1029-8479 |
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Notes |
WOS:000347685500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2077 |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Precise measurements of the properties of the B-1(5721)(0,+) and B-2*(5747)(0,+) states and observation of B-+,B-0 pi(-,+) mass structures |
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Journal Article |
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Year |
2015 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
024 - 27pp |
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Keywords |
Spectroscopy; Hadron-Hadron Scattering; QCD; B physics; Flavor physics |
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Abstract |
Invariant mass distributions of B (+) pi (-) and B (0) pi (+) combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb(-1) of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B (1)(5721)(0,+) and B (2)(5747)(0,+) states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850-6000 MeV in both B (+) pi (-) and B (0) pi (+) combinations. The structures are consistent with the presence of four excited B mesons, labelled B (J) (5840)(0,+) and B (J) (5960)(0,+), whose masses and widths are obtained under different hypotheses for their quantum numbers. |
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Address |
[Bediaga, I.; De Miranda, J. M.; Ferreira Rodrigues, F.; Gomes, A.; Massafferri, A.; Rodrigues, B. Osorio; dos Reis, A. C.; Rodrigues, A. B.] CBPF, Rio De Janeiro, Brazil, Email: vladimir.gligorov@cern.ch |
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Springer |
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1029-8479 |
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WOS:000353555200001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2217 |
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Permanent link to this record |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Forward production of Upsilon mesons in pp collisions at root s=7 and 8 TeV |
Type |
Journal Article |
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Year |
2015 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
11 |
Issue |
11 |
Pages |
103 - 34pp |
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Keywords |
Spectroscopy; Quarkonium; Hadron-Hadron Scattering; QCD; Hard scattering |
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Abstract |
The production of Upsilon mesons in pp collisions at root s = 7 and 8 TeV is studied with the LHCb detector using data samples corresponding to an integrated luminosity of 1 fb(-1) and 2 fb(-1) respectively. The production cross-sections and ratios of cross-sections are measured as functions of the meson transverse momentum p and rapidity y, for p < 30 GeV/c and 2.0 < y < 4.5. |
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Address |
[Bediaga, I.; De Miranda, J. M.; Ferreira Rodrigues, F.; Gomes, A.; Massafferri, A.; Osorio Rodrigues, B.; dos Reis, A. C.; Rodrigues, A. B.] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil, Email: Ivan.Belyaev@itep.ru |
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1029-8479 |
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Notes |
WOS:000365101600001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2457 |
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Permanent link to this record |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Observation of the B (s) (0) -> J/psi phi phi decay |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
040 - 18pp |
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Keywords |
B physics; Branching fraction; Hadron-Hadron scattering; QCD; Spectroscopy |
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Abstract |
The B (s) (0) -> J/psi phi phi decay is observed in pp collision data corresponding to an integrated luminosity of 3 fb(-1) recorded by the LHCb detector at centre-of-mass energies of 7 TeV and 8 TeV. This is the first observation of this decay channel, with a statistical significance of 15 standard deviations. The mass of the B (s) (0) meson is measured to be 5367.08 +/- 0.38 +/- 0.15 MeV/c(2). The branching fraction ratio B[B(s)(0) -> J/psi phi phi]/B[B(s)(0) -> J/psi phi] is measured to be 0.0115 +/- 0.0012 (- 0.0009) (+ 0.0005) . In both cases, the first uncertainty is statistical and the second is systematic. No evidence for non-resonant B(s)(0) -> J/psi phi K (+) K (-) or B(s)(0) -> J/psi K (+) K (-) K (+) K (-) decays is found. |
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Address |
[Bediaga, I.; De Miranda, J. M.; Ferreira Rodrigues, F.; Gomes, A.; Massafferri, A.; Osorio Rodrigues, B.; dos Reis, A. C.; Rodrigues, A. B.] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil, Email: emanuelesantovetti@gmail.com |
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Publisher ![sorted by Publisher field, ascending order (up)](img/sort_asc.gif) |
Springer |
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English |
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1029-8479 |
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WOS:000372307900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2586 |
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Permanent link to this record |