Abstract: The International Fusion Materials Irradiation Facility- DEMO Oriented Neutron Source (IFMIF-DONES) is a scientific infrastructure aimed to provide an intense neutron source for the qualification of materials to be used in future fusion power reactors. Its implementation is critical for the construction of the fusion DEMOnstration Power Plant (DEMO). IFMIF-DONES is a unique facility requiring a broad set of technologies. Although most of the necessary technologies have already been validated, there are still some aspects that introduce risks in the evolution of the project. In order to mitigate these risks, a consortium of companies, with the support of research centres and the funding of the CDTI (Centre for the Development of Industrial Technology and Innovation), has launched the DONES EVO Programme, which comprises six lines of research: center dot Improvement of signal transmission and integrity (planning and integration risks) center dot Optimisation of RF conditioning processes (planning and reliability risks) center dot Development of a reliable beam extraction device (reliability risks) center dot Development of technologies for the production of medical isotopes (reliability risks) center dot Improvement of critical parts of the lithium purification system (safety and reliability risks) center dot Validation of the manufacture of critical components with special materials (reliability risk). DONES EVO will focus on developing the appropriate response to the risks identified in the IFMIFDONES project through research and prototyping around the associated technologies.

Abstract: A method for deriving 3D internal information in conventional X-ray settings is presented. It is based on the combination of a pair of radiographs from a patient and it avoids the use of X-ray-opaque fiducials and external reference structures. To achieve this goal, we augment an ordinary X-ray device with a consumer RGB-D camera. The patient' s rotation around the craniocaudal axis is tracked relative to this camera thanks to the depth information provided and the application of a modern surface-mapping algorithm. The measured spatial information is then translated to the reference frame of the X-ray imaging system. By using the intrinsic parameters of the diagnostic equipment, epipolar geometry, and X-ray images of the patient at different angles, 3D internal positions can be obtained. Both the RGB-D and Xray instruments are first geometrically calibrated to find their joint spatial transformation. The proposed method is applied to three rotating phantoms. The first two consist of an anthropomorphic head and a torso, which are filled with spherical lead bearings at precise locations. The third one is made of simple foam and has metal needles of several known lengths embedded in it. The results show that it is possible to resolve anatomical positions and lengths with a millimetric level of precision. With the proposed approach, internal 3D reconstructed coordinates and distances can be provided to the physician. It also contributes to reducing the invasiveness of ordinary X-ray environments and can replace other types of clinical explorations that are mainly aimed at measuring or geometrically relating elements that are present inside the patient's body.

Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.

Abstract: Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs.

Abstract: The AMADEUS (ANTARES Modules for the Acoustic Detection Under the Sea) system which is described in this article aims at the investigation of techniques for acoustic detection of neutrinos in the deep sea. It is integrated into the ANTARES neutrino telescope in the Mediterranean Sea. Its acoustic sensors, installed at water depths between 2050 and 2300 m, employ piezo-electric elements for the broad-band recording of signals with frequencies ranging up to 125 kHz. The typical sensitivity of the sensors is around – 145 dB re 1 V/mu Pa (including preamplifier). Completed in May 2008, AMADEUS consists of six “acoustic clusters”, each comprising six acoustic sensors that are arranged at distances of roughly 1 m from each other. Two vertical mechanical structures (so-called lines) of the ANTARES detector host three acoustic clusters each. Spacings between the clusters range from 14.5 to 340 m. Each cluster contains custom-designed electronics boards to amplify and digitise the acoustic signals from the sensors. An on-shore computer cluster is used to process and filter the data stream and store the selected events. The daily volume of recorded data is about 10 GB. The system is operating continuously and automatically, requiring only little human intervention. AMADEUS allows for extensive studies of both transient signals and ambient noise in the deep sea, as well as signal correlations on several length scales and localisation of acoustic point sources. Thus the system is excellently suited to assess the background conditions for the measurement of the bipolar pulses expected to originate from neutrino interactions.