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Author |
Brzezinski, K. et al |
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Title |
Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
145016 - 17pp |
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Keywords |
proton therapy; positron emission tomography; in vivo range verification; J-PET; Monte Carlo |
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Abstract |
Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. |
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Address |
[Brzezinski, Karol; Gajewski, Jan; Kopec, Renata; Olko, Pawel; Stasica, Paulina; Rucinski, Antoni] Polish Acad Sci, Inst Nucl Phys, Krakow, Poland, Email: karol.brzezinski@ific.uv.es |
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Publisher  |
IOP Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Notes |
WOS:001026535700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5616 |
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Author |
Zhang, X.; Xiao, Y.T.; Gimeno, B. |
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Title |
Multipactor Suppression by a Resonant Static Magnetic Field on a Dielectric Surface |
Type |
Journal Article |
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Year |
2020 |
Publication |
IEEE Transactions on Electron Devices |
Abbreviated Journal |
IEEE Trans. Electron Devices |
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Volume |
67 |
Issue |
12 |
Pages |
5723-5728 |
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Keywords |
Radio frequency; Dielectrics; Magnetic resonance; Discharges (electric); Surface discharges; Surface waves; Electrostatics; Monte Carlo simulation; multipactor discharge; orthogonal waves; resonant static magnetic field; secondary electron yield |
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Abstract |
In this article, we study the suppression of the multipactor phenomenon on a dielectric surface by a resonant static magnetic field. A homemade Monte Carlo algorithm is developed for multipactor simulations on a dielectric surface driven by two orthogonal radio frequency (RF) electric field components. When the static magnetic field is perpendicular to the tangential and normal RF electric fields, it is shown that if the normal electric field lags the tangential electric field by pi/2, the superposition of the normal and tangential electric fields will trigger a gyro-acceleration of the electron cloud and restrain the multipactor discharge effectively. By contrast, when the normal electric field is in advance of the tangential electric field by pi/2, the difference between the normal and tangential electric fields drives gyro-motion of the electron cloud. Consequently, two enhanced discharge zones are inevitable. The suppression effects of the resonant static magnetic field that is parallel to the tangential RF electric field or to the normal RF electric field are also presented. |
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Address |
[Zhang, Xue; Xiao, Yuting] Xiangtan Univ, Sch Automat & Elect Informat, Xiangtan 411105, Hunan, Peoples R China, Email: zhangxue.iecas@yahoo.com; |
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Ieee-Inst Electrical Electronics Engineers Inc |
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English |
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ISSN |
0018-9383 |
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Notes |
WOS:000594337700064 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4627 |
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Author |
Asai, M.; Cortes-Giraldo, M.A.; Gimenez-Alventosa, V.; Gimenez, V.; Salvat, F. |
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Title |
The PENELOPE Physics Models and Transport Mechanics. Implementation into Geant4 |
Type |
Journal Article |
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Year |
2021 |
Publication |
Frontiers in Physics |
Abbreviated Journal |
Front. Physics |
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Volume |
9 |
Issue |
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Pages |
738735 - 20pp |
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Keywords |
coupled electron-photon transport; Monte Carlo simulation; PENELOPE code system; random-hinge method; Geant4 toolkit |
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Abstract |
A translation of the penelope physics subroutines to C++, designed as an extension of the Geant4 toolkit, is presented. The Fortran code system penelope performs Monte Carlo simulation of coupled electron-photon transport in arbitrary materials for a wide energy range, nominally from 50 eV up to 1 GeV. Penelope implements the most reliable interaction models that are currently available, limited only by the required generality of the code. In addition, the transport of electrons and positrons is simulated by means of an elaborate class II scheme in which hard interactions (involving deflection angles or energy transfers larger than pre-defined cutoffs) are simulated from the associated restricted differential cross sections. After a brief description of the interaction models adopted for photons and electrons/positrons, we describe the details of the class-II algorithm used for tracking electrons and positrons. The C++ classes are adapted to the specific code structure of Geant4. They provide a complete description of the interactions and transport mechanics of electrons/positrons and photons in arbitrary materials, which can be activated from the G4ProcessManager to produce simulation results equivalent to those from the original penelope programs. The combined code, named PenG4, benefits from the multi-threading capabilities and advanced geometry and statistical tools of Geant4. |
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Address |
[Asai, Makoto] SLAC Natl Accelerator Lab, Menlo Pk, CA USA, Email: miancortes@us.es; |
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Frontiers Media Sa |
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English |
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Series Volume |
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Edition |
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ISSN |
2296-424x |
ISBN |
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Conference |
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Notes |
WOS:000742889400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5080 |
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Author |
Martin-Luna, P.; Esperante, D.; Prieto, A.F.; Fuster-Martinez, N.; Rivas, I.G.; Gimeno, B.; Ginestar, D.; Gonzalez-Iglesias, D.; Hueso, J.L.; Llosa, G.; Martinez-Reviriego, P.; Meneses-Felipe, A.; Riera, J.; Regueiro, P.V.; Hueso-Gonzalez, F. |
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Title |
Simulation of electron transport and secondary emission in a photomultiplier tube and validation |
Type |
Journal Article |
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Year |
2024 |
Publication |
Sensors and Actuators A-Physical |
Abbreviated Journal |
Sens. Actuator A-Phys. |
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Volume |
365 |
Issue |
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Pages |
114859 - 10pp |
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Keywords |
Photomultiplier tube; Photodetector; Proton therapy; Monte Carlo simulation; Measurement |
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Abstract |
The electron amplification and transport within a photomultiplier tube (PMT) has been investigated by developing an in-house Monte Carlo simulation code. The secondary electron emission in the dynodes is implemented via an effective electron model and the Modified Vaughan's model, whereas the transport is computed with the Boris leapfrog algorithm. The PMT gain, rise time and transit time have been studied as a function of supply voltage and external magnetostatic field. A good agreement with experimental measurements using a Hamamatsu R13408-100 PMT was obtained. The simulations have been conducted following different treatments of the underlying geometry: three-dimensional, two-dimensional and intermediate (2.5D). The validity of these approaches is compared. The developed framework will help in understanding the behavior of PMTs under highly intense and irregular illumination or varying external magnetic fields, as in the case of prompt gamma-ray measurements during pencil-beam proton therapy; and aid in optimizing the design of voltage dividers with behavioral circuit models. |
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Address |
[Martin-Luna, Pablo; Esperante, Daniel; Fuster-Martinez, Nuria; Gimeno, Benito; Gonzalez-Iglesias, Daniel; Llosa, Gabriela; Martinez-Reviriego, Pablo; Meneses-Felipe, Alba; Hueso-Gonzalez, Fernando] CSIC UV, Inst Fis Corpuscular IFIC, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: pablo.martin@uv.es |
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Publisher |
Elsevier Science Sa |
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English |
Summary Language |
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ISSN |
0924-4247 |
ISBN |
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Notes |
WOS:001131902700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5876 |
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Author |
ATLAS Collaboration (Adragna, P. et al); Castelo, J.; Castillo Gimenez, V.; Cuenca, C.; Ferrer, A.; Fullana, E.; Gonzalez, V.; Higon-Rodriguez, E.; Poveda, J.; Ruiz, A.; Salvachua, B.; Sanchis, E.; Solans, C.; Torres, J.; Valero, A.; Valls Ferrer, J.A. |
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Title |
Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
615 |
Issue |
2 |
Pages |
158-181 |
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Keywords |
Calorimeter; Test-beam; ATLAS; Monte Carlo simulation; GEANT4; Hadronic shower development; Pion-proton response; Longitudinal shower profile for hadrons |
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Abstract |
The response of pions and protons in the energy range of 20-180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron-scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parametrization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parametrized as a function of the beam energy and the calorimeter depth. This allows for a leakage correction of test-beam results in the standard projective geometry. |
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Address |
[Hakobyan, H.; Simonyan, M.] Yerevan Phys Inst, Yerevan 375036, Armenia, Email: Margar.Simonyan@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Notes |
ISI:000276299900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
252 |
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