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Author |
Verdu-Andres, S.; Amaldi, U.; Faus-Golfe, A. |
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Title |
CABOTO, a high-gradient linac for hadrontherapy |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Radiation Research |
Abbreviated Journal |
J. Radiat. Res. |
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Volume |
54 |
Issue |
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Pages |
155-161 |
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Keywords |
hadrontherapy; high-gradient linac; cyclinac; carbon ion therapy; multipainting |
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Abstract |
The field of hadrontherapy has grown rapidly in recent years. At present the therapeutic beam is provided by a cyclotron or a synchrotron, but neither cyclotrons nor synchrotrons present the best performances for hadrontherapy. The new generation of accelerators for hadrontherapy should allow fast active energy modulation and have a high repetition rate, so that moving organs can be appropriately treated in a reasonable time. In addition, a reduction of the dimensions and cost of the accelerators for hadrontherapy would make the acquisition and operation of a hadrontherapy facility more affordable, which would translate into great benefits for the potential hadrontherapy patients. The 'cyclinac', an accelerator concept that combines a cyclotron with a high-frequency linear accelerator (linac), is a fast-cycling machine specifically conceived to allow for fast active energy modulation. The present paper focuses on CABOTO (CArbon BOoster for Therapy in Oncology), a compact, efficient high-frequency linac that can accelerate C6+ ions and H-2 molecules from 150-410 MeV/u in similar to 24 m. The paper presents the latest design of CABOTO and discusses its performances. |
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Address |
[Verdu-Andres, Silvia; Amaldi, Ugo] Fdn Tera, I-28100 Novara, Italy, Email: sverdu@bnl.gov |
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Oxford Univ Press |
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English |
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ISSN |
0449-3060 |
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Expedition |
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Conference |
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Notes |
WOS:000321463900021 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1506 |
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Author |
Roman, F.L.; Abler, D.; Kanellopoulos, V.; Amoros, G.; Davies, J.; Dosanjh, M.; Jena, R.; Kirkby, N.; Peach, K.; Salt, J. |
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Title |
Hadron therapy information sharing prototype |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Radiation Research |
Abbreviated Journal |
J. Radiat. Res. |
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Volume |
54 |
Issue |
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Pages |
56-60 |
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Keywords |
hadron therapy; proton therapy; data federation; web portal; eHealth; cancer informatics |
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Abstract |
The European PARTNER project developed a prototypical system for sharing hadron therapy data. This system allows doctors and patients to record and report treatment-related events during and after hadron therapy. It presents doctors and statisticians with an integrated view of adverse events across institutions, using open-source components for data federation, semantics, and analysis. There is a particular emphasis upon semantic consistency, achieved through intelligent, annotated form designs. The system as presented is ready for use in a clinical setting, and amenable to further customization. The essential contribution of the work reported here lies in the novel data integration and reporting methods, as well as the approach to software sustainability achieved through the use of community-supported open-source components. |
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Address |
[Roman, Faustin Laurentiu; Abler, Daniel; Kanellopoulos, Vassiliki; Dosanjh, Manjit] CERN, European Org Nucl Res, CH-1211 Geneva 23, Switzerland, Email: faustin.roman@medaustron.at |
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Publisher |
Oxford Univ Press |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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ISSN |
0449-3060 |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000321463900008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1519 |
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Author |
Vijande, J.; Granero, D.; Perez-Calatayud, J.; Ballester, F. |
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Title |
Monte Carlo dosimetric study of the medium dose rate CSM40 source |
Type |
Journal Article |
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Year |
2013 |
Publication |
Applied Radiation and Isotopes |
Abbreviated Journal |
Appl. Radiat. Isot. |
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Volume |
82 |
Issue |
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Pages |
283-288 |
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Keywords |
Brachytherapy; Cs-137 seed; TG-43 based dosimetry; Monte Carlo |
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Abstract |
The Cs-137 medium dose rate (MDR) CSM40 source model (Eckert & Ziegler BEBIG, Germany) is in clinical use but no dosimetric dataset has been published. This study aims to obtain dosimetric data for the CSM40 source for its use in clinical practice as required by the American Association of Physicists in Medicine (AAPM) and the European Society for Radiotherapy and Oncology (ESTRO). Penelope2008 and Geant4 Monte Carlo codes were used to characterize this source dosimetrically. It was located in an unbounded water phantom with composition and mass density as recommended by AAPM and ESTRO. Due to the low photon energies of Cs-137, absorbed dose was approximated by collisional kerma. Additional simulations were performed to obtain the air-kerma strength, sic. Mass-energy absorption coefficients in water and air were consistently derived and used to calculate collisional kerma. Results performed with both radiation transport codes showed agreement typically within 0.05%. Dose rate constant, radial dose function and anisotropy function are provided for the CSM40 and compared with published data for other commercially available Cs-137 sources. An uncertainty analysis has been performed. The data provided by this study can be used as input data and verification in the treatment planning systems. (C) 2013 Elsevier Ltd. All rights reserved. |
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Address |
[Vijande, J.; Ballester, F.] Univ Valencia, Dept Atom Mol & Nucl Phys, E-46100 Burjassot, Spain, Email: Javier.vijande@uv.es |
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Thesis |
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Publisher |
Pergamon-Elsevier Science Ltd |
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Language |
English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Edition |
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ISSN |
0969-8043 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000328804000043 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1678 |
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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
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Title |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Public Library Science |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Edition |
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ISSN |
1545-7885 |
ISBN |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1446 |
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Author |
ANTARES Collaboration (Tamburini, C. et al); Aguilar, J.A.; Bigongiari, C.; Dornic, D.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Mangano, S.; Ruiz-Rivas, J.; Salesa, F.; Sanchez-Losa, A.; Toscano, S.; Yepes, H.; Zornoza, J.D.; Zuñiga, J. |
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Title |
Deep-Sea Bioluminescence Blooms after Dense Water Formation at the Ocean Surface |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos One |
Abbreviated Journal |
PLoS One |
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Volume |
8 |
Issue |
7 |
Pages |
e67523 - 10pp |
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Keywords |
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Abstract |
The deep ocean is the largest and least known ecosystem on Earth. It hosts numerous pelagic organisms, most of which are able to emit light. Here we present a unique data set consisting of a 2.5-year long record of light emission by deep-sea pelagic organisms, measured from December 2007 to June 2010 at the ANTARES underwater neutrino telescope in the deep NW Mediterranean Sea, jointly with synchronous hydrological records. This is the longest continuous time-series of deep-sea bioluminescence ever recorded. Our record reveals several weeks long, seasonal bioluminescence blooms with light intensity up to two orders of magnitude higher than background values, which correlate to changes in the properties of deep waters. Such changes are triggered by the winter cooling and evaporation experienced by the upper ocean layer in the Gulf of Lion that leads to the formation and subsequent sinking of dense water through a process known as “open-sea convection”. It episodically renews the deep water of the study area and conveys fresh organic matter that fuels the deep ecosystems. Luminous bacteria most likely are the main contributors to the observed deep-sea bioluminescence blooms. Our observations demonstrate a consistent and rapid connection between deep open-sea convection and bathypelagic biological activity, as expressed by bioluminescence. In a setting where dense water formation events are likely to decline under global warming scenarios enhancing ocean stratification, in situ observatories become essential as environmental sentinels for the monitoring and understanding of deep-sea ecosystem shifts. |
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Address |
[Tamburini, Christian; Lefevre, Dominique; Martini, Verine; Robert, Anne; Dekeyser, Ivan; Fuda, Jean-Luc] Aix Marseille Univ, CNRS INSU, IRD, MIO,U110, Marseille, France, Email: christian.tamburini@univ-amu.fr; |
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Publisher |
Public Library Science |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1932-6203 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000321765300012 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1496 |
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Author |
n_TOF Collaboration (Guerrero, C. et al); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L. |
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Title |
Performance of the neutron time-of-flight facility n_TOF at CERN |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
49 |
Issue |
2 |
Pages |
27 - 15pp |
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Keywords |
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Abstract |
The neutron time-of-flight facility n_TOF features a white neutron source produced by spallation through 20 GeV/c protons impinging on a lead target. The facility, aiming primarily at the measurement of neutron-induced reaction cross sections, was operating at CERN between 2001 and 2004, and then underwent a major upgrade in 2008. This paper presents in detail all the characteristics of the new neutron beam in the currently available configurations, which correspond to two different collimation systems and two choices of neutron moderator. The characteristics discussed include the intensity and energy dependence of the neutron flux, the spatial profile of the beam, the in-beam background components and the energy resolution/broadening. The discussion of these features is based on dedicated measurements and Monte Carlo simulations, and includes estimations of the systematic uncertainties of the mentioned quantities. |
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Address |
[Guerrero, C.; Tsinganis, A.; Berthoumieux, E.; Weiss, C.; Chiaveri, E.; Calviani, M.; Vlachoudis, V.; Andriamonje, S.; Boccone, V.; Brugger, M.; Cerutti, F.; Chin, M.; Ferrari, A.; Hernandez-Prieto, A.; Kadi, Y.; Losito, R.; Roman, F.; Rubbia, C.; Versaci, R.] CERN, European Org Nucl Res, CH-1211 Geneva, Switzerland, Email: carlos.guerrero@cern.ch |
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Corporate Author |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000315601600011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1358 |
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| Permanent link to this record |
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Author |
Xiao, C.W.; Aceti, F.; Bayar, M. |
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Title |
The small K pi component in the K* wave functions |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
49 |
Issue |
2 |
Pages |
22 - 5pp |
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Keywords |
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Abstract |
We use a recently developed formalism which generalizes Weinberg's compositeness condition to partial waves higher than s-wave in order to determine the probability of having a K pi component in the K* wave function. A fit is made to the K pi phase shifts in p-wave, from where the coupling of K* to K pi and the K pi loop function are determined. These ingredients allow us to determine that the K* is a genuine state, different from a K pi component, in a proportion of about 80%. |
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Address |
[Xiao, C. W.; Aceti, F.; Bayar, M.] Ctr Mixto Univ Valencia CSIC, Inst Invest Paterna, Dept Fis Teor, Valencia 46071, Spain, Email: xiaochw@ific.uv.es |
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Corporate Author |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000315601600006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1359 |
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| Permanent link to this record |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
ATLAS search for new phenomena in dijet mass and angular distributions using pp collisions at root s=7 TeV |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
01 |
Issue |
1 |
Pages |
029 - 46pp |
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Keywords |
Hadron-Hadron Scattering |
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Abstract |
Mass and angular distributions of dijets produced in LHC proton-proton collisions at a centre-of-mass energy root s = 7TeV have been studied with the ATLAS detector using the full 2011 data set with an integrated luminosity of 4.8 fb(-1). Dijet masses up to similar to 4.0TeV have been probed. No resonance-like features have been observed in the dijet mass spectrum, and all angular distributions are consistent with the predictions of QCD. Exclusion limits on six hypotheses of new phenomena have been set at 95% CL in terms of mass or energy scale, as appropriate. These hypotheses include excited quarks below 2.83 TeV, colour octet scalars below 1.86TeV, heavy W bosons below 1.68 TeV, string resonances below 3.61 TeV, quantum black holes with six extra space-time dimensions for quantum gravity scales below 4.11 TeV, and quark contact interactions below a compositeness scale of 7.6 TeV in a destructive interference scenario. |
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Address |
[Jackson, P.; Soni, N.] Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1126-6708 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000315583200029 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1363 |
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| Permanent link to this record |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Search for direct chargino production in anomaly-mediated supersymmetry breaking models based on a disappearing-track signature in pp collisions at root s=7 TeV with the ATLAS detector |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
01 |
Issue |
1 |
Pages |
131 - 34pp |
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Keywords |
Hadron-Hadron Scattering |
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Abstract |
A search for direct chargino production in anomaly-mediated supersymmetry breaking scenarios is performed in p p collisions at root s = 7 TeV using 4.7 fb(-1) of data collected with the ATLAS experiment at the LHC. In these models, the lightest chargino is predicted to have a lifetime long enough to be detected in the tracking detectors of collider experiments. This analysis explores such models by searching for chargino decays that result in tracks with few associated hits in the outer region of the tracking system. The transverse-momentum spectrum of candidate tracks is found to be consistent with the expectation from the Standard Model background processes and constraints on chargino properties are obtained. |
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Address |
[Jackson, P.; Soni, N.] Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1126-6708 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000315583600050 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1364 |
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| Permanent link to this record |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Measurement of isolated-photon pair production in pp collisions at root s=7 TeV with the ATLAS detector |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
01 |
Issue |
1 |
Pages |
086 - 42pp |
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Keywords |
Hadron-Hadron Scattering |
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Abstract |
The ATLAS experiment at the LHC has measured the production cross section of events with two isolated photons in the final state, in proton-proton collisions at root s = 7 TeV. The full data set collected in 2011, corresponding to an integrated luminosity of 4.9 fb(-1), is used. The amount of background, from hadronic jets and isolated electrons, is estimated with data-driven techniques and subtracted. The total cross section, for two isolated photons with transverse energies above 25 GeV and 22 GeV respectively, in the acceptance of the electromagnetic calorimeter (vertical bar eta vertical bar < 1.37 and 1.52 < vertical bar eta vertical bar 2.37) and with an angular separation Delta R > 0.4, is 44.0(-4.2)(+3.2) pb. The differential cross sections as a function of the di-photon invariant mass, transverse momentum, azimuthal separation, and cosine of the polar angle of the largest transverse energy photon in the Collins-Soper di-photon rest frame are also measured. The results are compared to the prediction of leading-order parton-shower and next-to-leading-order and next-to-next-to-leading-order parton-level generators. |
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Address |
[Jackson, P.; Soni, N.] Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia |
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Publisher |
Springer |
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English |
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ISSN |
1126-6708 |
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Notes |
WOS:000315583600005 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
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1365 |
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