Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.

Abstract: The neutron time-of-flight facility nTOF at CERN is a spallation source dedicated to measurements of neutroninduced reaction cross-sections of interest in nuclear technologies, astrophysics, and other applications. Since 2014, Experimental ARea 2 (EAR2) is operational and delivers a neutron fluence of similar to 4 center dot 10(7) neutrons per nominal proton pulse, which is similar to 50 times higher than the one of Experimental ARea 1 (EAR1) of similar to 8 center dot 10(5) neutrons per pulse. The high neutron flux at EAR2 results in high counting rates in the detectors that challenged the previously existing capture detection systems. For this reason, a Segmented Total Energy Detector (sTED) has been developed to overcome the limitations in the detector's response, by reducing the active volume per module and by using a photo-multiplier (PMT) optimized for high counting rates. This paper presents the main characteristics of the sTED, including energy and time resolution, response to gamma-rays, and provides as well details of the use of the Pulse Height Weighting Technique (PHWT) with this detector. The sTED has been validated to perform neutron-capture cross-section measurements in EAR2 in the neutron energy range from thermal up to at least 400 keV. The detector has already been successfully used in several measurements at nTOF EAR2.

Abstract: The particle spectrum of all Majorana neutrino mass models with spontaneous violation of global lepton number include a Goldstone boson, the so-called majoron. The presence of this massless pseudoscalar changes the phenomenology dramatically. In this work we derive general analytical expressions for the 1-loop coupling of the majoron to charged leptons. These can be applied to any model featuring a majoron that have a clear hierarchy of energy scales, required for an expansion in powers of the low-energy scale to be valid. We show how to use our general results by applying them to some example models, finding full agreement with previous results in several popular scenarios and deriving novel ones in other setups.

Abstract: This study focuses on investigating a regular black hole within the framework of Verlinde's emergent gravity. In particular, we explore the main aspects of the modified Simpson-Visser solution. Our analysis reveals the presence of a unique physical event horizon under certain conditions. Moreover, we study the thermodynamic properties, including the Hawking temperature, the entropy, and the heat capacity. Based on these quantities, our results indicate several phase transitions. Geodesic trajectories for photon-like particles, encompassing photon spheres and the formation of black hole shadows, are also calculated to comprehend the behavior of light in the vicinity of the black hole. Additionally, we also provide the calculation of the time delay and the deflection angle. Corroborating our results, we include an additional application in the context of high-energy astrophysical phenomena: neutrino energy deposition. Finally, we investigate the quasinormal modes using third-order WKB approximation.

Abstract: The next-generation water Cherenkov Hyper-Kamiokande detector will be able to detect thousands of neutrino events from a galactic Supernova explosion via Inverse Beta Decay processes followed by neutron capture on Gadolinium. This superb statistics provides a unique window to set bounds on neutrino properties, as its mass and lifetime. We shall explore the capabilities of such a future detector, constraining the former two properties via the time delay and the flux suppression induced in the Supernovae neutrino time and energy spectra. Special attention will be devoted to the statistically sub-dominant elastic scattering induced events, normally neglected, which can substantially improve the neutrino mass bound via time delays. When allowing for a invisible decaying scenario, the 95% CL lower bound on tau/m\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\tau /m$$\end{document} is almost one order of magnitude better than the one found with SN1987A neutrino events. Simultaneous limits can be set on both m nu\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$m\nu $$\end{document} and tau nu\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\tau {\nu }$$\end{document}, combining the neutrino flux suppression with the time-delay signature: the best constrained lifetime is that of nu 1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\nu 1$$\end{document}, which has the richest electronic component. We find tau nu 1 greater than or similar to 4x105\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\tau {\nu _1}\gtrsim 4\times 10<^>5$$\end{document} s at 95% CL. The tightest 95% CL bound on the neutrino mass we find is 0.34 eV, which is not only competitive with the tightest neutrino mass limits nowadays, but also comparable to future laboratory direct mass searches. Both mass and lifetime limits are independent on the mass ordering, which makes our results very robust and relevant.