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Author |
Carrasco-Ribelles, L.A.; Pardo-Mas, J.R.; Tortajada, S.; Saez, C.; Valdivieso, B.; Garcia-Gomez, J.M. |
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Title |
Predicting morbidity by local similarities in multi-scale patient trajectories |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of Biomedical Informatics |
Abbreviated Journal |
J. Biomed. Inform. |
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Volume |
120 |
Issue |
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Pages |
103837 - 9pp |
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Keywords |
Patient trajectory; Risk prediction; Local alignment; Dynamic programming; Diabetes; Cardiovascular disease |
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Abstract |
Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening. |
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Address |
[Carrasco-Ribelles, Lucia A.; Pardo-Mas, Jose Ramon; Saez, Carlos; Garcia-Gomez, Juan M.] Univ Politecn Valencia, Biomed Data Sci Lab BDSLAB, Inst Tecnol Informat & Comunicac ITACA, Camino Vera S-N, Valencia 46022, Spain, Email: lucarri@etsii.upv.es; |
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Publisher  |
Academic Press Inc Elsevier Science |
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Language |
English |
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Series Volume |
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ISSN |
1532-0464 |
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Conference |
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Notes |
WOS:000683527500003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4934 |
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Author |
Moles-Valls, R. |
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Title |
Alignment of the ATLAS Inner Detector with proton-proton collision data |
Type |
Journal Article |
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Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
650 |
Issue |
1 |
Pages |
235-239 |
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Keywords |
ATLAS; Inner detector; Tracking system; Alignment |
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Abstract |
ATLAS is a multipurpose experiment that records the products of the LHC collisions. In order to reconstruct the trajectories of the charged particles produced in these collisions. ATLAS has an internal tracking system made of silicon planar sensors (pixels and micro-strips) and drift-tube based detectors; both together, they constitute the ATLAS Inner Detector. The alignment of the ATLAS tracking system requires the determination of their almost 36,000 degrees-of-freedom (DOF) with high accuracy. Thus, the demanded precision for the alignment of the pixel and micro-strip sensors is below 10 μm. As alignment algorithms are based on the minimization of the track-hit residuals, a linear system with a large number of DOF has to be solved. The alignment results of the ATLAS tracker using data recorded during cosmic commissioning phases in 2008 and 2009 and the LHC start up run in 2009 will be presented. Moreover recent 7 TeV data collected during 2010 run have been used to study the detector performance. These studies reveal that the detector is aligned with a precision high enough to cope with the requirements. |
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Address |
[Moles-Valls, R] IFIC CSIC UV Valencia, Valencia, Spain, Email: Regina.Moles@ific.uv.es |
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Publisher |
Elsevier Science Bv |
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English |
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ISSN |
0168-9002 |
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Notes |
WOS:000295106500050 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
767 |
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Author |
Yepes, H. |
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Title |
The ANTARES neutrino detector instrumentation |
Type |
Journal Article |
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Year |
2012 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
7 |
Issue |
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Pages |
C01022 - 9pp |
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Keywords |
Large detector-systems performance; Performance of High Energy Physics Detectors; Detector alignment and calibration methods (lasers, sources, particle-beams) |
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Abstract |
ANTARES is actually the fully operational and the largest neutrino telescope in the Northern hemisphere. Located in the Mediterranean Sea, it consists of a 3D array of 885 photomultiplier tubes (PMTs) arranged in 12 detection lines (25 storeys each), able to detect the Cherenkov light induced by upgoing relativistic muons produced in the interaction of high energy cosmic neutrinos with the detector surroundings. Among its physics goals, the search for neutrino astrophysical sources and the indirect detection of dark matter particles coming from the sun are of particular interest. To reach these goals, good accuracy in track reconstruction is mandatory, so several calibration systems for timing and positioning have been developed. In this contribution we will present the design of the detector, calibration systems, associated equipment and its performance on track reconstruction. |
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Address |
Univ Valencia, CSIC, Inst Fis Corpuscular IFIC, E-46071 Valencia, Spain, Email: Harold.Yepes@ific.uv.es |
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Corporate Author |
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Publisher |
Iop Publishing Ltd |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000303806200022 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1041 |
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Author |
ANTARES Collaboration (Adrian-Martinez, S. et al); Aguilar, J.A.; Bigongiari, C.; Dornic, D.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Mangano, S.; Real, D.; Ruiz-Rivas, J.; Salesa, F.; Sanchez-Losa, A.; Toscano, S.; Yepes, H.; Zornoza, J.D.; Zuñiga, J. |
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Title |
The positioning system of the ANTARES Neutrino Telescope |
Type |
Journal Article |
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Year |
2012 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
7 |
Issue |
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Pages |
T08002 - 20pp |
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Keywords |
Timing detectors; Detector modelling and simulations II (electric fields, charge transport, multiplication and induction, pulse formation, electron emission, etc); Detector alignment and calibration methods (lasers, sources, particle-beams); Detector control systems (detector and experiment monitoring and slow-control systems, architecture, hardware, algorithms, databases) |
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Abstract |
The ANTARES neutrino telescope, located 40km off the coast of Toulon in the Mediterranean Sea at a mooring depth of about 2475m, consists of twelve detection lines equipped typically with 25 storeys. Every storey carries three optical modules that detect Cherenkov light induced by charged secondary particles (typically muons) coming from neutrino interactions. As these lines are flexible structures fixed to the sea bed and held taut by a buoy, sea currents cause the lines to move and the storeys to rotate. The knowledge of the position of the optical modules with a precision better than 10cm is essential for a good reconstruction of particle tracks. In this paper the ANTARES positioning system is described. It consists of an acoustic positioning system, for distance triangulation, and a compass-tiltmeter system, for the measurement of the orientation and inclination of the storeys. Necessary corrections are discussed and the results of the detector alignment procedure are described. |
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Address |
[Anton, G.; Eberl, T.; Enzenhoefer, A.; Folger, F.; Fritsch, U.; Graf, K.; Herold, B.; Hoessl, J.; Kalekin, O.; Kappes, A.; Katz, U.; Kopper, C.; Lahmann, R.; Meli, A.; Motz, H.; Neff, M.; Richardt, C.; Richter, R.; Roensch, K.; Schoeck, F.; Seitz, T.; Shanidze, R.; Spies, A.; Wagner, S.] Univ Erlangen Nurnberg, Erlangen Ctr Astroparticle Phys, D-91058 Erlangen, Germany, Email: juergen.hoessl@physik.uni-erlangen.de |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000308869800043 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1176 |
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Author |
Pierre Auger Collaboration (Abreu, P. et al); Pastor, S. |
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Title |
Techniques for measuring aerosol attenuation using the Central Laser Facility at the Pierre Auger Observatory |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
8 |
Issue |
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Pages |
P04009 - 28pp |
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Keywords |
Data analysis; Large detector systems for particle and astroparticle physics; Detector alignment and calibration methods (lasers, sources, particle-beams) |
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Abstract |
The Pierre Auger Observatory in Malargue, Argentina, is designed to study the properties of ultra-high energy cosmic rays with energies above 10(18) eV. It is a hybrid facility that employs a Fluorescence Detector to perform nearly calorimetric measurements of Extensive Air Shower energies. To obtain reliable calorimetric information from the FD, the atmospheric conditions at the observatory need to be continuously monitored during data acquisition. In particular, light attenuation due to aerosols is an important atmospheric correction. The aerosol concentration is highly variable, so that the aerosol attenuation needs to be evaluated hourly. We use light from the Central Laser Facility, located near the center of the observatory site, having an optical signature comparable to that of the highest energy showers detected by the FD. This paper presents two procedures developed to retrieve the aerosol attenuation of fluorescence light from CLF laser shots. Cross checks between the two methods demonstrate that results from both analyses are compatible, and that the uncertainties are well understood. The measurements of the aerosol attenuation provided by the two procedures are currently used at the Pierre Auger Observatory to reconstruct air shower data. |
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Address |
Ctr Atom Bariloche, San Carlos De Bariloche, Rio Negro, Argentina |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000317462400016 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1413 |
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