Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.

Abstract: A search for the doubly charmed baryon Omega(+)(cc) with the decay mode Omega(+)(cc) -> Xi K-+(c)-pi(+) is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb(-1). No significant signal is observed within the invariant mass range of 3.6 to 4.0GeV/c(2). Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the Omega(+)(cc) -> Xi K-+(c)-pi(+) decay with respect to the Xi(++)(cc) -> Lambda K-+(c)-pi(+)pi(+) decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for different hypotheses on the Omega(+)(cc) mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

Abstract: First evidence of a structure in the J/psi Lambda invariant mass distribution is obtained from an amplitude analysis of Xi(-)(b) -> J/psi Lambda K- decays. The observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere effect. Its mass and width are determined to be 4458.8 +/- 2.9(-1.1)(+4.7) MeV and 17.3 +/- 6.5(-5.7)(+8.0) MeV, respectively, where the quoted uncertainties are statistical and systematic. The structure is also consistent with being due to two resonances. In addition, the narrow excited Xi(-) states, Xi(-)(1690) and Xi(-)(1820)(-), are seen for the first time in a Xi(-)(b) decay, and their masses and widths are measured with improved precision. The analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb(-1), collected with the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV.