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Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year |
2024 |
Publication  |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
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Keywords |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Corporate Author |
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Thesis |
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Publisher |
Nature Portfolio |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2045-2322 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Henry, L.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanchez Mayordomo, C. |
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Title |
Search for the doubly charmed baryon Xi(+)(cc) |
Type |
Journal Article |
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Year |
2020 |
Publication |
Science China-Physics Mechanics & Astronomy |
Abbreviated Journal |
Sci. China-Phys. Mech. Astron. |
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Volume |
63 |
Issue |
2 |
Pages |
221062 - 15pp |
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Keywords |
charmed baryons; limits on production of particles; charmed quarks; experimental tests |
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Abstract |
A search for the doubly charmed baryon.+ cc is performed through its decay to the.+ c K- p+ final state, using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7, 8 and 13 TeV. The data correspond to a total integrated luminosity of 9 fb-1. No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c2. Upper limits are set at 95% credibility level on the ratio of the.+ cc production cross-section times the branching fraction to that of.+ c and.++ cc baryons. The limits are determined as functions of the.+ cc mass for di fferent lifetime hypotheses, in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c. |
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Address |
[Bediaga, I.; Cruz Torres, M.; De Miranda, J. M.; Gomes, A.; Massafferri, A.; dos Reis, A. C.; Soares Lavra, L.; Tourinho Jadallah Aoude, R.] CBPF, Rio De Janeiro, Brazil, Email: maria.vieites.diaz@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Science Press |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1674-7348 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000526889100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4376 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J. |
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Title |
Search for the doubly charmed baryon Omega(+)(cc) |
Type |
Journal Article |
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Year |
2021 |
Publication |
Science China-Physics Mechanics & Astronomy |
Abbreviated Journal |
Sci. China-Phys. Mech. Astron. |
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Volume |
64 |
Issue |
10 |
Pages |
101062 - 12pp |
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Keywords |
charmed baryons; limits on production of particles; charmed quarks; experimental tests |
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Abstract |
A search for the doubly charmed baryon Omega(+)(cc) with the decay mode Omega(+)(cc) -> Xi K-+(c)-pi(+) is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb(-1). No significant signal is observed within the invariant mass range of 3.6 to 4.0GeV/c(2). Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the Omega(+)(cc) -> Xi K-+(c)-pi(+) decay with respect to the Xi(++)(cc) -> Lambda K-+(c)-pi(+)pi(+) decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for different hypotheses on the Omega(+)(cc) mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c. |
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Address |
[Baptista Leite, J.; Bediaga, I; Cruz Torres, M.; De Miranda, J. M.; dos Reis, A. C.; Gomes, A.; Massafferri, A.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil |
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Corporate Author |
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Thesis |
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Publisher |
Science Press |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1674-7348 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000694853300003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4971 |
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| Permanent link to this record |
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Author |
LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Henry, L.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanchez Mayordomo, C. |
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Title |
Observation of structure in the J/psi-pair mass spectrum |
Type |
Journal Article |
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Year |
2020 |
Publication |
Science Bulletin |
Abbreviated Journal |
Sci. Bull. |
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Volume |
65 |
Issue |
23 |
Pages |
1983-1993 |
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Keywords |
QCD; Exotics; Tetraquark; Spectroscopy; Quarkonium; Particle and resonance production |
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Abstract |
Using proton-proton collision data at centre-of-mass energies of root s = 7, 8 and 13 TeV recorded by the LHCb experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 9 fb(-1), the invariant mass spectrum of J/psi pairs is studied. A narrow structure around 6.9 GeV/c(2) matching the line-shape of a resonance and a broad structure just above twice the J/psi mass are observed. The deviation of the data from nonresonant J/psi-pair production is above five standard deviations in the mass region between 6.2 and 7.4 GeV/c(2), covering predicted masses of states composed of four charm quarks. The mass and natural width of the narrow X(6900) structure are measured assuming a Breit-Wigner lineshape. |
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Address |
[Bediaga, I.; Cruz Torres, M.; De Miranda, J. M.; Gomes, A.; Massafferri, A.; dos Reis, A. C.; Soares Lavra, L.; Tourinho Jadallah Aoude, R.] CBPF, Rio De Janeiro, Brazil, Email: maria.vieites.diaz@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2095-9273 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000593153200012 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4622 |
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Author |
LHCb Collaboration (Aaij, R. et al); Henry, L.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J. |
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Title |
Evidence of a J/psi Lambda structure and observation of excited Xi(-) states in the Xi(-)(b) -> J/psi Lambda K- decay |
Type |
Journal Article |
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Year |
2021 |
Publication |
Science Bulletin |
Abbreviated Journal |
Sci. Bull. |
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Volume |
66 |
Issue |
13 |
Pages |
1278-1287 |
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Keywords |
QCD; Exotics; Pentaquark; Spectroscopy; Quarkonium; Particle and resonance production |
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Abstract |
First evidence of a structure in the J/psi Lambda invariant mass distribution is obtained from an amplitude analysis of Xi(-)(b) -> J/psi Lambda K- decays. The observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere effect. Its mass and width are determined to be 4458.8 +/- 2.9(-1.1)(+4.7) MeV and 17.3 +/- 6.5(-5.7)(+8.0) MeV, respectively, where the quoted uncertainties are statistical and systematic. The structure is also consistent with being due to two resonances. In addition, the narrow excited Xi(-) states, Xi(-)(1690) and Xi(-)(1820)(-), are seen for the first time in a Xi(-)(b) decay, and their masses and widths are measured with improved precision. The analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb(-1), collected with the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV. |
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Address |
[Leite, J. Baptista; Bediaga, I; Torres, M. Cruz; De Miranda, J. M.; dos Reis, A. C.; Gomes, A.; Massafferri, A.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2095-9273 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000668689800009 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4888 |
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| Permanent link to this record |
