Abstract: We present a detailed study of the lowest-lying 1/2(-) and 3/2(-) Lambda Q resonances both in the heavy 2 2 quark (bottom and charm) and the strange sectors. We have paid special attention to the interplay between the constituent quark-model and chiral baryon-meson degrees of freedom, which are coupled using a unitarized scheme consistent with leading-order heavy quark symmetries. We show that the Lambda(b)(5912) [J(P) = 1/2(-)], Lambda(b)(5920) [J(P) = 3/2(-)] and the Lambda(c)(2625) [J(P) = 3/2-], and the Lambda(1520) [J(P) = 3/2(-)] admitting larger breaking corrections, are heavyquark spin-flavor siblings. They can be seen as dressed quark-model states with Sigma Q(()*()) pi molecular components of the order of 30%. The J(P)=1(-) Lambda(2595) has, however, a higher molecular 2 probability of at least 50%, and even values greater than 70% can be easily accommodated. This is because it is located almost on top of the threshold of the Sigma(c)pi pair, which largely influences its properties. Although the light degrees of freedom in this resonance would be coupled to spin-parity 1(-) as in the Lambda(b)(5912), Lambda(b)(5920) and Lambda(c)(2625), the Lambda(c)(2595) should not be considered as a heavy-quark spin-flavor partner of the former ones. We also show that the Lambda(1405) chiral two-pole pattern does not have analogs in the 1 – charmed and bottomed sectors, because the 2 N D-(*()) and N (B) over bar (()*()) channels do not play for heavy quarks the decisive role that the N (K) over bar does in the strange sector, and the notable influence of the bare quark-model states for the charm and bottom resonances. Finally, we predict the existence of two Lambda(b)(6070) and two Lambda(c)(2765) heavy-quark spin and flavor sibling odd parity states.

Abstract: The t (t) over bar + jet + X differential cross-section in proton-proton collisions at 7 TeV centre of mass energy is investigated with respect to its sensitivity to the top quark mass. The analysis includes higher order QCD corrections at NLO. The impact of the renormalization scale (mu(R)), the factorization (mu(F)) scale and of the choice of different proton's PDF (parton distribution function) has been evaluated. In this study it is concluded that differential jet rates offer a promising option for alternative mass measurements of the top quark, with theoretical uncertainties below 1 GeV.

Abstract: Neocortical local field potentials have shown that gamma oscillations occur spontaneously during slow-wave sleep (SWS). At the macroscopic EEG level in the human brain, no evidences were reported so far. In this study, by using simultaneous scalp and intracranial EEG recordings in 20 epileptic subjects, we examined gamma oscillations in cerebral cortex during SWS. We report that gamma oscillations in low (30-50 Hz) and high (60-120 Hz) frequency bands recurrently emerged in all investigated regions and their amplitudes coincided with specific phases of the cortical slow wave. In most of the cases, multiple oscillatory bursts in different frequency bands from 30 to 120 Hz were correlated with positive peaks of scalp slow waves (“IN-phase'' pattern), confirming previous animal findings. In addition, we report another gamma pattern that appears preferentially during the negative phase of the slow wave (”ANTI-phase'' pattern). This new pattern presented dominant peaks in the high gamma range and was preferentially expressed in the temporal cortex. Finally, we found that the spatial coherence between cortical sites exhibiting gamma activities was local and fell off quickly when computed between distant sites. Overall, these results provide the first human evidences that gamma oscillations can be observed in macroscopic EEG recordings during sleep. They support the concept that these high-frequency activities might be associated with phasic increases of neural activity during slow oscillations. Such patterned activity in the sleeping brain could play a role in off-line processing of cortical networks.

Abstract: Random coincidences degrade the image in Positron Emission Tomography, PET. To compensate for their degradation effects, the rate of random coincidences should be estimated. Under certain circumstances, current estimation methods fail to provide accurate results. We propose a novel method, “Singles-Prompts” (SP), that includes the information conveyed by prompt coincidences and models the pile-up. The SP method has the same structure than the well-known “Singles Rate” (SR) approach. Hence, SP can straightforwardly replace SR. In this work, the SP method has been extensively assessed and compared to two conventional methods, SR and the delayed window (DW) method, in a preclinical PET scenario using Monte-Carlo simulations. SP offers accurate estimates for the randoms rates, while SR and DW tend to overestimate the rates (similar to 10%, and 5%, respectively). With pile-up, the SP method is more robust than SR (but less than DW). At the image level, the contrast is overestimated in SR-corrected images, + 16%, while SP produces the correct value. Spill-over is slightly reduced using SP instead of SR. The DW images values are similar to those of SP except for low-statistic scenarios, where DW behaves as if randoms were not compensated for. In particular, the contrast is reduced, -16%. In general, the better estimations of SP translate into better image quality.

Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.