| |
Records |
Links |
|
Author |
Sanjuan, R.; Nebot, M.; Chirico, N.; Mansky, L.M.; Belshaw, R. |
|
| |
Title |
Viral Mutation Rates |
Type |
Journal Article |
| |
Year |
2010 |
Publication  |
Journal of Virology |
Abbreviated Journal |
J. Virol. |
|
| |
Volume |
84 |
Issue |
19 |
Pages |
9733-9748 |
|
| |
Keywords |
|
|
| |
Abstract |
Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut. |
|
| |
Address |
[Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolutiva, Dept Genet, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Amer Soc Microbiology |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0022-538x |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
ISI:000282641800008 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ elepoucu @ |
Serial |
371 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Botella, F.J.; Cornet-Gomez, F.; Miro, C.; Nebot, M. |
|
| |
Title |
New physics hints from τ scalar interactions and (g-2)e,μ |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of Physics G |
Abbreviated Journal |
J. Phys. G |
|
| |
Volume |
51 |
Issue |
2 |
Pages |
025001 - 20pp |
|
| |
Keywords |
lepton sector; extended scalar sector; new physics signals |
|
| |
Abstract |
We consider a flavour conserving two Higgs doublet model that consists of a type I (or X) quark sector and a generalized lepton sector where the Yukawa couplings of the charged leptons to the new scalars are not proportional to the lepton masses. The model, previously proposed to solve both muon and electron g – 2 anomalies simultaneously, is also capable to accommodate the ATLAS excess in pp -> S -> tau(+)tau(-) with gluon-gluon fusion production in the invariant mass range [0.2; 0.6] TeV, including all relevant low and high energy constraints. The excess is reproduced taking into account the new contributions from the scalar H, the pseudoscalar A, or both. In particular, detailed numerical analyses favoured the solution with a significant hierarchy among the vevs of the two Higgs doublets, t(beta)similar to 10, and light neutral scalars satisfying m(A) > m(H) with sizable couplings to tau leptons. In this region of the parameter space, the muon g – 2 anomaly receives one and two-loop (Barr Zee) contributions of similar size, while the electron anomaly is explained at two loops. An analogous ATLAS excess in b-associated production and the CMS excess in ditop production are also studied. Further New Physics prospects concerning the anomalous magnetic moment of the tau lepton and the implications of the CDF M-W measurement on the final results are discussed. |
|
| |
Address |
[Botella, Francisco J.; Miro, Carlos; Nebot, Miguel] Univ Valencia, CSIC, Dept Fis Teor, E-46100 Burjassot, Spain, Email: Francisco.J.Botella@uv.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
IOP Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0954-3899 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001132956900001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
5877 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Botella, F.J.; Branco, G.C.; Nebot, M.; Rebelo, M.N. |
|
| |
Title |
Two-Higgs leptonic minimal flavour violation |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
10 |
Issue |
10 |
Pages |
037 - 21pp |
|
| |
Keywords |
Higgs Physics; Beyond Standard Model; Neutrino Physics |
|
| |
Abstract |
We construct extensions of the Standard Model with two Higgs doublets, where there are flavour changing neutral currents both in the quark and leptonic sectors, with their strength fixed by the fermion mixing matrices V(CKM) and V(PMNS). These models are an extension to the leptonic sector of the class of models previously considered by Branco, Grimus and Lavoura, for the quark sector. We consider both the cases of Dirac and Majorana neutrinos and identify the minimal discrete symmetry required in order to implement the models in a natural way. |
|
| |
Address |
[Botella, F. J.; Nebot, M.] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Burjassot, Spain, Email: fbotella@uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1126-6708 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000296917100037 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
830 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Botella, F.J.; Branco, G.C.; Nebot, M. |
|
| |
Title |
The hunt for New Physics in the Flavour Sector with up vector-like quarks |
Type |
Journal Article |
| |
Year |
2012 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
12 |
Issue |
12 |
Pages |
040 - 34pp |
|
| |
Keywords |
Beyond Standard Model; Rare Decays; CP violation |
|
| |
Abstract |
We analyse the possible presence of New Physics (NP) in the Flavour Sector and evaluate its potential for solving the tension between the experimental values of A(J/Psi KS) and Br(B+ -> tau(+)v(tau)) with respect to the Standard Model (SM) expectations. Updated model independent analyses, where NP contributions are allowed in B-d(0) – (B) over bar (0)(d) and B-s(0) – (B) over bar (0)(s) transitions, suggest the need of New Physics in the bd sector. A detailed analysis of recent Flavour data is then presented in the framework of a simple extension of the SM, where a Q = 2/3 vector-like isosinglet quark is added to the spectrum of the SM. Special emphasis is given to the implications of this model for correlations among various measurable quantities. We include constraints from all the relevant quark flavour sectors and give precise predictions for selected rare processes. We find important deviations from the SM in observables in the bd sector like the semileptonic asymmetry A(SL)(d), B-d(0) -> mu(+)mu(-) and A(SL)(s) – A(SL)(d). Other potential places where NP can show up include A(J/Psi Phi), gamma, K-L(0) -> pi(0)v (v) over bar, t -> Zq and D-0 -> mu(+)mu(-) among others. The experimental data favours in this model the existence of an up vector-like quark with a mass below 600(1000) GeV at 1(2) sigma. |
|
| |
Address |
[Botella, F. J.; Nebot, M.] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Burjassot, Spain, Email: fbotella@uv.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1126-6708 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000313123800040 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1344 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Botella, F.J.; Branco, G.C.; Carmona, A.; Nebot, M.; Pedro, L.; Rebelo, M.N. |
|
| |
Title |
Physical constraints on a class of two-Higgs doublet models with FCNC at tree level |
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
07 |
Issue |
7 |
Pages |
078 - 33pp |
|
| |
Keywords |
Higgs Physics; Beyond Standard Model |
|
| |
Abstract |
We analyse the constraints and some of the phenomenological implications of a class of two Higgs doublet models where there are flavour-changing neutral currents (FCNC) at tree level but the potentially dangerous FCNC couplings are suppressed by small entries of the CKM matrix V. This class of models have the remarkable feature that, as a result of a discrete symmetry of the Lagrangian, the FCNC couplings are entirely fixed in the quark sector by V and the ratio v(2)/v(1) of the vevs of the neutral Higgs. The discrete symmetry is extended to the leptonic sector, so that there are FCNC in the leptonic sector with their flavour structure fixed by the leptonic mixing matrix. We analyse a large number of processes, including decays mediated by charged Higgs at tree level, processes involving FCNC at tree level, as well as loop induced processes. We show that in this class of models one has new physical scalars beyond the standard Higgs boson, with masses reachable at the next round of experiments. |
|
| |
Address |
[Botella, F. J.] Univ Valencia, CSIC, Dept Fis Teor, E-46100 Burjassot, Spain, Email: fbotella@uv.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000339805600001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1867 |
|
| Permanent link to this record |
