| |
Records |
Links |
|
Author |
Baran, J. et al; Brzezinski, K. |
|
| |
Title |
Feasibility of the J-PET to monitor the range of therapeutic proton beams |
Type |
Journal Article |
| |
Year |
2024 |
Publication  |
Physica Medica |
Abbreviated Journal |
Phys. Medica |
|
| |
Volume |
118 |
Issue |
|
Pages |
103301 - 9pp |
|
| |
Keywords |
PET; Range monitoring; J-PET; Monte Carlo simulations; Proton radiotherapy |
|
| |
Abstract |
Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application. |
|
| |
Address |
[Baran, Jakub; Silarski, Michal; Chug, Neha; Coussat, Aurelien; Czerwinski, Eryk; Dadgar, Meysam; Dulski, Kamil; Eliyan, Kavya, V; Gajos, Aleksander; Kacprzak, Krzysztof; Kaplon, Lukasz; Korcyl, Grzegorz; Kozik, Tomasz; Kumar, Deepak; Niedzwiecki, Szymon; Panek, Dominik; Parzych, Szymon; del Rio, Elena Perez; Simbarashe, Moyo; Sharma, Sushil; Shivani; Skurzok, Magdalena; Stepien, Ewa L.; Tayefi, Keyvan; Tayefi, Faranak; Moskal, Pawel] Jagiellonian Univ, Fac Phys Astron & Appl Comp Sci, 11 Lojasiewicza St, PL-30348 Krakow, Poland, Email: jakubbaran92@gmail.com |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Sci Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1120-1797 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001178648400001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
5990 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
|
| |
Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
| |
Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
|
| |
Volume |
35 |
Issue |
5 |
Pages |
446-452 |
|
| |
Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
|
| |
Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
|
| |
Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Lippincott Williams & Wilkins |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0143-3636 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000334103800002 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1763 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Beltrame, P. et al; Oliver, J.F.; Rafecas, M.; Solevi, P. |
|
| |
Title |
The AX-PET demonstrator-Design, construction and characterization |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
654 |
Issue |
1 |
Pages |
546-559 |
|
| |
Keywords |
PET; Axial geometry; Geiger-mode Avalanche Photo Diodes (G-APD); SiPM |
|
| |
Abstract |
Axial PET is a novel geometrical concept for Positron Emission Tomography (PET), based on layers of long scintillating crystals axially aligned with the bore axis. The axial coordinate is obtained from arrays of wavelength shifting (WLS) plastic strips placed orthogonally to the crystals. This article describes the design, construction and performance evaluation of a demonstrator set-up which consists of two identical detector modules, used in coincidence. Each module comprises 48 LYSO crystals of 100 mm length and 156 WLS strips. Crystals and strips are readout by Geiger-mode Avalanche Photo Diodes (G-APDs). The signals from the two modules are processed by fully analog front-end electronics and recorded in coincidence by a VME-based data acquisition system. Measurements with point-like (22)Na sources, with the modules used both individually and in coincidence mode, allowed for a complete performance evaluation up to the focal plane reconstruction of point sources. The results obtained are in good agreement with expectations and proved the set-up to be ready for the next evaluation phase with PET phantoms filled with radiotracers. |
|
| |
Address |
[Casella, C; Dissertori, G; Djambazov, L; Lustermann, W; Nessi-Tedaldi, F; Pauss, F; Renker, D; Schinzel, D] ETH, Inst Particle Phys, CH-8093 Zurich, Switzerland, Email: Chiara.Casella@cern.ch |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000295765100078 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
790 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Carles, M.; Lerche, C.W.; Sanchez, F.; Mora, F.; Benlloch, J.M. |
|
| |
Title |
Position correction with depth of interaction information for a small animal PET system |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
648 |
Issue |
|
Pages |
S176-S180 |
|
| |
Keywords |
DOI; PET; Positioning algorithm; Gamma ray imaging; Continuous scintillators |
|
| |
Abstract |
In this work we study the effects on the spatial resolution when depth of interaction (001) information is included in the parameterization of the line of response (LOR) for a small animal positron emission tomography (PET) system. One of the most important degrading factors for PET is the parallax error introduced in systems that do not provide DOI information of the recorded gamma-rays. Our group has designed a simple and inexpensive method for DOI determination in continuous scintillation crystals. This method is based, on one hand, in the correlation between the scintillation light distribution width in monolithic crystals and the DOI, and, on the other hand, on a small modification of the widely applied charge dividing circuits (CDR). In this work we present a new system calibration that includes the DOI information, and also the development of the correction equations that relates the LOR without and with DOI information. We report the results obtained for different measurements along the transaxial field of view (FOV) and the image quality enhancement achieved specially at the edge of the FOV. |
|
| |
Address |
[Carles, M.; Sanchez, F.; Benlloch, J. M.] Inst Fis Corpuscular CSIC UV, Valencia 46071, Spain, Email: montcar@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000305376900046 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
no |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1067 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Soriano, A.; Gonzalez, A.; Orero, A.; Moliner, L.; Carles, M.; Sanchez, F.; Benlloch, J.M.; Correcher, C.; Carrilero, V.; Seimetz, M. |
|
| |
Title |
Attenuation correction without transmission scan for the MAMMI breast PET |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
648 |
Issue |
|
Pages |
S75-S78 |
|
| |
Keywords |
Breast PET; Attenuation correction |
|
| |
Abstract |
Whole-body Positron Emission Tomography (PET) scanners are required in order to span large Fields of View (FOV). Therefore, reaching the sensitivity and spatial resolution required for early stage breast tumor detection is not straightforward. MAMMI is a dedicated breast PET scanner with a ring geometry designed to provide PET images with a spatial resolution as high as 1.5 mm, being able to detect small breast tumors ( < 1 cm). The patient lays down in prone position during the scan, thus making possible to image the whole breast, up to regions close to the base of the pectoral without the requirement of breast compression. Attenuation correction (AC) for PET data improves the image quality and the quantitative accuracy of radioactivity distribution determination. In dedicated, high resolution breast cancer scanners, this correction would enhance the proper diagnosis in early disease stages. In whole-body PET scanners, AC is usually taken into account with the use of transmission scans, either by external radioactive rod sources or by Computed Tomography (CT). This considerably increases the radiation dose administered to the patient and time needed for the exploration. In this work we propose a method for breast shape identification by means of PET image segmentation. The breast shape identification will be used for the determination of the AC. For the case of a specific breast PET scanner the procedure we propose should provide AC similar to that obtained by transmission scans as we take advantage of the breast anatomical simplicity. Experimental validation of the proposed approach with a dedicated breast PET prototype is also presented. The main advantage of this method is an important dose reduction since the transmission scan is not required. |
|
| |
Address |
[Soriano, A.; Orero, A.; Moliner, L.; Carles, M.; Sanchez, F.; Benlloch, J. M.] Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Paterna, Spain, Email: soriano@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000305376900021 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
no |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1069 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Studen, A.; Chesi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Honscheid, K.; Kagan, H.; Lacasta, C.; Llosa, G.; Linhart, V.; Mikuz, M.; Stankova, V.; Weilhammer, P.; Zontar, D. |
|
| |
Title |
A silicon PET probe |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
648 |
Issue |
|
Pages |
S255-S258 |
|
| |
Keywords |
PET; Silicon detectors |
|
| |
Abstract |
PET scanners with high spatial resolution offer a great potential in improving diagnosis, therapy monitoring and treatment validation for several severe diseases. One way to improve resolution of a PET scanner is to extend a conventional PET ring with a small probe with excellent spatial resolution. The probe is intended to be placed close to the area of interest. The coincidences of interactions within the probe and the external ring provide a subset of data which combined with data from external ring, greatly improve resolution in the area viewed by the probe. Our collaboration is developing a prototype of a PET probe, composed of high-resolution silicon pad detectors. The detectors are 1 mm thick, measuring 40 by 26 mm(2), and several such sensors are envisaged to either compensate for low stopping power of silicon or increase the area covered by the probe. The sensors are segmented into 1 mm(3) cubic voxels, giving 1040 readout pads per sensor. A module is composed of two sensors placed in a back-to-back configuration, allowing for stacking fraction of up to 70% within a module. The pads are coupled to a set of 16 ASICs (VaTaGP7.1 by IDEAS) per module and read out through a custom designed data acquisition board, allowing for trigger and data interfacing with the external ring. This paper presents an overview of probe requirements and expected performance parameters. It will focus on the characteristics of the silicon modules and their impact on overall probe performance, including spatial resolution, energy resolution and timing resolution. We will show that 1 mm(3) voxels will significantly extend the spatial resolution of conventional PET rings, and that broadening of timing resolution related to varying depth of photon interactions can be compensated to match the timing resolution of the external ring. The initial test results of the probe will also be presented. |
|
| |
Address |
[Studen, A.; Cindro, V.; Grosicar, B.; Mikuz, M.; Zontar, D.] Jozef Stefan Inst, Ljubljana, Slovenia, Email: andrej.studen@ijs.si |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000305376900063 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1070 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Bolle, E.; Casella, C.; Chesi, E.; De Leo, R.; Dissertori, G.; Fanti, V.; Gillam, J.E.; Heller, M.; Joram, C.; Lustermann, W.; Nappi, E.; Oliver, J.F.; Pauss, F.; Rafecas, M.; Rudge, A.; Ruotsalainen, U.; Schinzel, D.; Schneider, T.; Seguinot, J.; Solevi, P.; Stapnes, S.; Tuna, U.; Weilhammer, P. |
|
| |
Title |
AX-PET: A novel PET concept with G-APD readout |
Type |
Journal Article |
| |
Year |
2012 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
695 |
Issue |
|
Pages |
129-134 |
|
| |
Keywords |
PET; Axial geometry; Geiger-mode Avalanche Photo Diodes (G-APD); SiPM |
|
| |
Abstract |
The AX-PET collaboration has developed a novel concept for high resolution PET imaging to overcome some of the performance limitations of classical PET cameras, in particular the compromise between spatial resolution and sensitivity introduced by the parallax error. The detector consists of an arrangement of long LYSO scintillating crystals axially oriented around the field of view together with arrays of wave length shifter strips orthogonal to the crystals. This matrix allows a precise 3D measurement of the photon interaction point. This is valid both for photoelectric absorption at 511 key and for Compton scattering down to deposited energies of about 100 keV. Crystals and WLS strips are individually read out using Geiger-mode Avalanche Photo Diodes (G-APDs). The sensitivity of such a detector can be adjusted by changing the number of layers and the resolution is defined by the crystal and strip dimensions. Two AX-PET modules were built and fully characterized in dedicated test set-ups at CERN, with point-like Na-22 sources. Their performance in terms of energy (Renew approximate to 11.8% (FWMH) at 511 key) and spatial resolution was assessed (sigma(axial) approximate to 0.65 mm), both individually and for the two modules in coincidence. Test campaigns at ETH Zurich and at the company AAA allowed the tomographic reconstructions of more complex phantoms validating the 3D reconstruction algorithms. The concept of the AX-PET modules will be presented together with some characterization results. We describe a count rate model which allows to optimize the planing of the tomographic scans. |
|
| |
Address |
[Heller, M.; Joram, C.; Schneider, T.; Seguinot, J.] CERN, PH Dept, CH-1211 Geneva, Switzerland, Email: Matthieu.Heller@cern.ch |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000311469900026 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1236 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Clinthorne, N.; Brzezinski, K.; Chesi, E.; Cochran, E.; Grkovski, M.; Grosicar, B.; Honscheid, K.; Huh, S.; Kagan, H.; Lacasta, C.; Linhart, V.; Mikuz, M.; Smith, D.S.; Stankova, V.; Studen, A.; Weilhammer, P.; Zontar, D. |
|
| |
Title |
Silicon as an unconventional detector in positron emission tomography |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
699 |
Issue |
|
Pages |
216-220 |
|
| |
Keywords |
PET; Silicon detectors; Multiresolution imaging; Magnifying PET |
|
| |
Abstract |
Positron emission tomography (PET) is a widely used technique in medical imaging and in studying small animal models of human disease. In the conventional approach, the 511 keV annihilation photons emitted from a patient or small animal are detected by a ring of scintillators such as LYSO read out by arrays of photodetectors. Although this has been successful in achieving similar to 5 mm FWHM spatial resolution in human studies and similar to 1 mm resolution in dedicated small animal instruments, there is interest in significantly improving these figures. Silicon, although its stopping power is modest for 511 keV photons, offers a number of potential advantages over more conventional approaches including the potential for high intrinsic spatial resolution in 3D. To evaluate silicon in a variety of PET “magnifying glass” configurations, an instrument was constructed that consists of an outer partial-ring of PET scintillation detectors into which various arrangements of silicon detectors are inserted to emulate dual-ring or imaging probe geometries. Measurements using the test instrument demonstrated the capability of clearly resolving point sources of Na-22 having a 1.5 mm center-to-center spacing as well as the 1.2 mm rods of a F-18-filled resolution phantom. Although many challenges remain, silicon has potential to become the PET detector of choice when spatial resolution is the primary consideration. (C) 2012 Elsevier B.V. All rights reserved. |
|
| |
Address |
[Clinthorne, Neal; Huh, Sam] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA, Email: nclintho@umich.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000312809200045 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1290 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Llosa, G.; Barrillon, P.; Barrio, J.; Bisogni, M.G.; Cabello, J.; Del Guerra, A.; Etxebeste, A.; Gillam, J.E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Stankova, V.; de La Taille, C. |
|
| |
Title |
High performance detector head for PET and PET/MR with continuous crystals and SiPMs |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
702 |
Issue |
|
Pages |
3-5 |
|
| |
Keywords |
Monolithic crystals; SiPM; MG-APD; PET; High resolution; Position determination |
|
| |
Abstract |
A high resolution PET detector head for small animal PET applications has been developed. The detector is composed of a 12 mm x 12 mm continuous LYSO crystal coupled to a 64-channel monolithic SiPM matrix from FBK-irst. Crystal thicknesses of 5 mm and 10 mm have been tested, both yielding an intrinsic spatial resolution around 0.7 mm FWHM with a position determination algorithm that can also provide depth-of-interaction information. The detectors have been tested in a rotating system that makes it possible to acquire tomographic data and reconstruct images of Na-22 sources. An image reconstruction method specifically adapted for continuous crystals has been employed. The Full Width at Half Maximum measured from a point source reconstructed with ML-EM was 0.7 mm with the 5 mm crystal and 0.8 mm with the 10 mm crystal. |
|
| |
Address |
[Llosa, G.; Barrio, J.; Cabello, J.; Etxebeste, A.; Gillam, J. E.; Lacasta, C.; Oliver, J. F.; Rafecas, M.; Solaz, C.; Stankova, V.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000314682300002 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1330 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Studen, A.; Brzezinski, K.; Chesi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Grkovski, M.; Honscheid, K.; Kagan, H.; Lacasta, C.; Llosa, G.; Mikuz, M.; Stankova, V.; Weilhammer, P.; Zontar, D. |
|
| |
Title |
Silicon detectors for combined MR-PET and MR-SPECT imaging |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
702 |
Issue |
|
Pages |
88-90 |
|
| |
Keywords |
PET; Silicon detectors; SPECT |
|
| |
Abstract |
Silicon based devices can extend PET-MR and SPECT-MR imaging to applications, where their advantages in performance outweigh benefits of high statistical counts. Silicon is in many ways an excellent detector material with numerous advantages, among others: excellent energy and spatial resolution, mature processing technology, large signal to noise ratio, relatively low price, availability, versatility and malleability. The signal in silicon is also immune to effects of magnetic field at the level normally used in MR devices. Tests in fields up to 7 T were performed in a study to determine effects of magnetic field on positron range in a silicon PET device. The curvature of positron tracks in direction perpendicular to the field's orientation shortens the distance between emission and annihilation point of the positron. The effect can be fully appreciated for a rotation of the sample for a fixed field direction, compressing range in all dimensions. A popular Ga-68 source was used showing a factor of 2 improvement in image noise compared to zero field operation. There was also a little increase in noise as the reconstructed resolution varied between 2.5 and 1.5 mm. A speculative applications can be recognized in both emission modalities, SPECT and PET. Compton camera is a subspecies of SPECT, where a silicon based scatter as a MR compatible part could inserted into the MR bore and the secondary detector could operate in less constrained environment away from the magnet. Introducing a Compton camera also relaxes requirements of the radiotracers used, extending the range of conceivable photon energies beyond 140.5 keV of the Tc-99m. In PET, one could exploit the compressed sub-millimeter range of positrons in the magnetic field. To exploit the advantage, detectors with spatial resolution commensurate to the effect must be used with silicon being an excellent candidate. Measurements performed outside of the MR achieving spatial resolution below 1 mm are reported. |
|
| |
Address |
[Studen, A.; Cindro, V.; Grosicar, B.; Grkovski, M.; Mikuz, M.; Zontar, D.] Jozef Stefan Inst, Ljubljana, Slovenia, Email: andrej.studen@ijs.si |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000314682300026 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1331 |
|
| Permanent link to this record |
