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Otal, A., Celada, F., Chimeno, J., Vijande, J., Pellejero, S., Perez-Calatayud, M. J., et al. (2022). Review on Treatment Planning Systems for Cervix Brachytherapy (Interventional Radiotherapy): Some Desirable and Convenient Practical Aspects to Be Implemented from Radiation Oncologist and Medical Physics Perspectives. Cancers, 14(14), 3467–15pp.
Abstract: Simple Summary There are no brachytherapy treatment planning systems (TPS) exclusively for the treatment of cervical tumours, so general-purpose TPSs are used. However, these treatments have some particular features concerning the treatment of other pathologies, especially in the case of exclusive use of MRI as an imaging modality and the presence of gynaecological applicators in combination with an interstitial part. That is why it is essential to review the latest versions of commercial TPSs to find the potential features to improve with the help of a group of experimented medical physicists and radiation oncologists. Furthermore, after reviewing the recent literature for advances applicable to cervical brachytherapy and through his own clinical experience, possible improvements are proposed to software providers for the development of new tools. Intracavitary brachytherapy (BT, Interventional Radiotherapy, IRT), plays an essential role in the curative intent of locally advanced cervical cancer, for which the conventional approach involves external beam radiotherapy with concurrent chemotherapy followed by BT. This work aims to review the different methodologies used by commercially available treatment planning systems (TPSs) in exclusive magnetic resonance imaging-based (MRI) cervix BT with interstitial component treatments. Practical aspects and improvements to be implemented into the TPSs are discussed. This review is based on the clinical expertise of a group of radiation oncologists and medical physicists and on interactive demos provided by the software manufacturers. The TPS versions considered include all the new tools currently in development for future commercial releases. The specialists from the supplier companies were asked to propose solutions to some of the challenges often encountered in a clinical environment through a questionnaire. The results include not only such answers but also comments by the authors that, in their opinion, could help solve the challenges covered in these questions. This study summarizes the possibilities offered nowadays by commercial TPSs, highlighting the absence of some useful tools that would notably improve the planning of MR-based interstitial component cervix brachytherapy.
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Oliver-Canamas, L., Vijande, J., Candela-Juan, C., Gimeno-Olmos, J., Pujades-Claumarchirant, M. C., Rovira-Escutia, J. J., et al. (2023). A User-Friendly System for Mailed Dosimetric Audits of Ir-192 or Co-60 HDR Brachytherapy Sources. Cancers, 15(9), 2484–14pp.
Abstract: Nowadays, the options available to perform external dosimetric audits of the high dose rate (HDR) brachytherapy treatment process are limited. In this work, we present a methodology that allows for performing dosimetric audits in this field. A phantom was designed and manufactured for this purpose. The criteria for its design, together with the in-house measurements for its characterization, are presented. The result is a user-friendly system that can be mailed to perform dosimetric audits in HDR brachytherapy on-site for systems using either Iridium-192 (Ir-192) or Cobalt-60 (Co-60) sources. Objectives: The main goal of this work is to design and characterize a user-friendly methodology to perform mailed dosimetric audits in high dose rate (HDR) brachytherapy for systems using either Iridium-192 (Ir-192) or Cobalt-60 (Co-60) sources. Methods: A solid phantom was designed and manufactured with four catheters and a central slot to place one dosimeter. Irradiations with an Elekta MicroSelectron V2 for Ir-192, and with a BEBIG Multisource for Co-60 were performed for its characterization. For the dose measurements, nanoDots, a type of optically stimulated luminescent dosimeters (OSLDs), were characterized. Monte Carlo (MC) simulations were performed to evaluate the scatter conditions of the irradiation set-up and to study differences in the photon spectra of different Ir-192 sources (Microselectron V2, Flexisource, BEBIG Ir2.A85-2 and Varisource VS2000) reaching the dosimeter in the irradiation set-up. Results: MC simulations indicate that the surface material on which the phantom is supported during the irradiations does not affect the absorbed dose in the nanoDot. Generally, differences below 5% were found in the photon spectra reaching the detector when comparing the Microselectron V2, the Flexisource and the BEBIG models. However, differences up to 20% are observed between the V2 and the Varisource VS2000 models. The calibration coefficients and the uncertainty in the dose measurement were evaluated. Conclusions: The system described here is able to perform dosimetric audits in HDR brachytherapy for systems using either Ir-192 or Co-60 sources. No significant differences are observed between the photon spectra reaching the detector for the MicroSelectron V2, the Flexisource and the BEBIG Ir-192 sources. For the Varisource VS2000, a higher uncertainty is considered in the dose measurement to allow for the nanoDot response.
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Wang, Y. F., Yao, D. L., & Zheng, H. Q. (2019). New insights on low energy pi N scattering amplitudes: comprehensive analyses at O (p(3)) level. Chin. Phys. C, 43(6), 064110–22pp.
Abstract: A production representation of partial-wave S matrix is utilized to construct low-energy elastic pion-nucleon scattering amplitudes from cuts and poles on complex Riemann sheets. Among them, the contribution of left-hand cuts is estimated using the O (p(3)) results obtained in covariant baryon chiral perturbation theory within the extendedon-nass-shell scheme. By fitting to data on partial-wave phase shifts, it is indicated that the existences of hidden poles in S-11 and P-11 channels, as conjectured in our previous paper [Eur. Phys. J. C, 78(7): 543 (2018)], are firmly established. Specifically, the pole mass of the S-11 hidden resonance is determined to be (895 +/- 81)-(164 +/- 23)i MeV, whereas, the virtual pole in the P-11 channel locates at (966 +/- 18) MeV. It is found that analyses at the O (p(3)) level improves significantly the fit quality, comparing with the previous O (p(2)) one. Quantitative studies with cautious physical discussions are also conducted for the other S- and P-wave channels.
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Cheng, L., Eberhardt, O., & Murphy, C. W. (2019). Novel theoretical constraints for color-octet scalar models. Chin. Phys. C, 43(9), 093101–11pp.
Abstract: We study the theoretical constraints on a model whose scalar sector contains one color octet and one or two color singlet SU(2)(L) doublets. To ensure unitarity of the theory, we constrain the parameters of the scalar potential for the first time at the next-to-leading order in perturbation theory. Moreover, we derive new conditions guaranteeing the stability of the potential. We employ the HEPfit package to extract viable parameter regions at the electroweak scale and test the stability of the renormalization group evolution up to the multi-TeV region. Furthermore, we set upper limits on the scalar mass splittings. All results are given for both cases with and without a second scalar color singlet.
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Wang, E., Xie, J. J., Geng, L. S., & Oset, E. (2019). The X(4140) and X(4160) resonances in the e(+)e(-) -> gamma J/psi phi reaction. Chin. Phys. C, 43(11), 113101–10pp.
Abstract: We investigate the J/psi phi invariant mass distribution in the e(+)e(-) -> gamma J/psi phi reaction at a center-of-mass energy of root s = 4.6 GeV measured by the BESIII collaboration, which concluded that no significant signals were observed for e(+)e(-) -> gamma J/psi phi because of the low statistics. We show, however, that the J/psi phi invariant mass distribution is compatible with the existence of the X(4140) state, appearing as a peak, and a strong cusp structure at the D-s*(D) over bar (s)* threshold, resulting from the molecular nature of the X(4160) state, which provides a substantial contribution to the reaction. This is consistent with our previous analysis of the B+ -> J psi phi K+ decay measured by the LHCb collaboration. We strongly suggest further measurements of this process with more statistics to clarify the nature of the X(4140) and X(4160) resonances.
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