Abstract: Background The role of chest radiography in COVID-19 disease has changed since the beginning of the pandemic from a diagnostic tool when microbiological resources were scarce to a different one focused on detecting and monitoring COVID-19 lung involvement. Using chest radiographs, early detection of the disease is still helpful in resource-poor environments. However, the sensitivity of a chest radiograph for diagnosing COVID-19 is modest, even for expert radiologists. In this paper, the performance of a deep learning algorithm on the first clinical encounter is evaluated and compared with a group of radiologists with different years of experience. Methods The algorithm uses an ensemble of four deep convolutional networks, Ensemble4Covid, trained to detect COVID-19 on frontal chest radiographs. The algorithm was tested using images from the first clinical encounter of positive and negative cases. Its performance was compared with five radiologists on a smaller test subset of patients. The algorithm's performance was also validated using the public dataset COVIDx. Results Compared to the consensus of five radiologists, the Ensemble4Covid model achieved an AUC of 0.85, whereas the radiologists achieved an AUC of 0.71. Compared with other state-of-the-art models, the performance of a single model of our ensemble achieved nonsignificant differences in the public dataset COVIDx. Conclusion The results show that the use of images from the first clinical encounter significantly drops the detection performance of COVID-19. The performance of our Ensemble4Covid under these challenging conditions is considerably higher compared to a consensus of five radiologists. Artificial intelligence can be used for the fast diagnosis of COVID-19.

Abstract: This work is devoted to study the behavior of massless particles within the context of curved spacetime. In essence, we investigate the consequences of the scale factor C(?) of the Friedmann-Robertson-Walker metric in the Einstein-aether formalism to study photon-like particles. To do so, we consider the system within the canonical ensemble formalism in order to derive the following thermodynamic state quantities: spectral radiance, Helmholtz free energy, pressure, entropy, mean energy and the heat capacity. Moreover, the correction to the Stefan-Boltzmann law and the equation of states are also provided. Particularly, we separate our study within three distinct cases, i.e. s = 0, p = 0; s = 1, p = 1; s = 2, p = 1. In the first one, the results are derived numerically. Nevertheless, for the rest of the cases, all the calculations are accomplished analytically showing explicitly the dependence of the scale factor C(?) and the Riemann zeta function ?(s). Furthermore, our analyses are accomplished in general taking into account three different regimes of temperature of the universe, i.e. the inflationary era (T = 10(13)GeV), the electroweak epoch (T = 10(3)GeV) and the cosmic microwave background (T = 10(-13)GeV).

Abstract: The framed Standard Model (FSM) predicts a 0(+) boson with mass around 20 MeV in the “hidden sector,” which mixes at tree level with the standard Higgs hW and hence acquires small couplings to quarks and leptons which can be calculated in the FSM apart from the mixing parameter rho Uh. The exchange of this mixed state U will contribute to g – 2 and to the Lamb shift. By adjusting rho Uh alone, it is found that the FSM can satisfy all present experimental bounds on the g – 2 and Lamb shift anomalies for μand e, and for the latter for both hydrogen and deuterium. The FSM predicts also a 1(-) boson in the “hidden sector” with a mass of 17 MeV, that is, right on top of the Atomki anomaly X. This mixes with the photon at 1-loop level and couples thereby like a dark photon to quarks and leptons. It is however a compound state and is thought likely to possess additional compound couplings to hadrons. By adjusting the mixing parameter and the X's compound coupling to nucleons, the FSM can reproduce the production rate of the X in beryllium decay as well as satisfy all the bounds on X listed so far in the literature. The above two results are consistent in that the U, being 0(+), does not contribute to the Atomki anomaly if parity and angular momentum are conserved, while X, though contributing to g – 2 and Lamb shift, has smaller couplings than U and can, at first instance, be neglected there. Thus, despite the tentative nature of the three anomalies in experiment on the one hand and of the FSM as theory on the other, the accommodation of the former in the latter has strengthened the credibility of both. Indeed, if this FSM interpretation were correct, it would change the whole aspect of the anomalies from just curiosities to windows into a vast hitherto hidden sector comprising at least in part the dark matter which makes up the bulk of our universe.

Abstract: A bonus of the framed Standard Model (FSM), constructed initially to explain the mass and mixing patterns of quarks and leptons, is a solution (without axions) of the strong CP problem by cancelling the theta-angle term theta(I) Tr(H-mu v H-mu v*) in coloura by a chiral transformation on a quark zero mode which is inherent in FSM, and produces thereby a CP-violating phase in the CKM matrix similar in size to what is observed.' Extending here to flavour, one finds that there are two terms proportional to Tr(G(mu v) G(mu v)*): (a) in the action from flavour instantons with unknown coefficient, say theta(I)', (b) induced by the above FSM solution to the strong CP-problem with therefore known coefficient theta(C)'. Both terms can be cancelled in the FSM by a chiral transformation on the lepton zero mode to give a Jarlskog invariant J' in the PMNS matrix for leptons of order 10(-2), as is hinted by the experiment. But if, as suggested in Ref. 2, the term theta(I)' is to be cancelled by a chiral transformation in the predicted hidden sector to solve the strong CP problem therein, leaving only the term theta(C)' to be cancelled by the chiral transformation on leptons, then the following prediction results: J' similar to -0.012 (delta(CP)'similar to (1.11)pi) which is (i) of the right order, (ii) of the right sign and (iii) in the range favoured by the present experiment. Together with the earlier result for quarks, this offers an attractive unified treatment of all known CP physics.

Abstract: Axion like particles (ALPs) and right-handed neutrinos (RHNs) are two well-motivated dark matter (DM) candidates. However, these two particles have a completely different origin. Axion was proposed to solve the strong CP problem, whereas RHNs were introduced to explain light neutrino masses through seesaw mechanisms. We study the case of ALP portal RHN DM (Majorana DM) taking into account existing constraints on ALPs. We consider the leading effective operators mediating interactions between the ALP and Standard Model (SM) particles and three RHNs to generate light neutrino masses through type-I seesaw. Further, ALP-RHN neutrino coupling is introduced to generalize the model which is restricted by the relic density and indirect detection constraint.