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Borys, D. et al, & Brzezinski, K. (2022). ProTheRaMon-a GATE simulation framework for proton therapy range monitoring using PET imaging. Phys. Med. Biol., 67(22), 224002–15pp.
Abstract: Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022).
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Borja-Lloret, M., Barrientos, L., Bernabeu, J., Lacasta, C., Muñoz, E., Ros, A., et al. (2023). Influence of the background in Compton camera images for proton therapy treatment monitoring. Phys. Med. Biol., 68(14), 144001–16pp.
Abstract: Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods.
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Brzezinski, K. et al. (2023). Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study. Phys. Med. Biol., 68(14), 145016–17pp.
Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.
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Vijande, J., Tedgren, A. C., Ballester, F., Baltas, D., Papagiannis, P., Rivard, M. J., et al. (2021). Source strength determination in iridium-192 and cobalt-60 brachytherapy: A European survey on the level of agreement between clinical measurements and manufacturer certificates. Phys. Imag. Radiat. Oncol., 19, 108–111.
Abstract: Background and purpose: Brachytherapy treatment outcomes depend on the accuracy of the delivered dose distribution, which is proportional to the reference air-kerma rate (RAKR). Current societal recommendations require the medical physicist to compare the measured RAKR values to the manufacturer source calibration certificate. The purpose of this work was to report agreement observed in current clinical practice in the European Union. Materials and methods: A European survey was performed for high- and pulsed-dose-rate (HDR and PDR) highenergy sources (Ir-192 and Co-60), to quantify observed RAKR differences. Medical physicists at eighteen hospitals from eight European countries were contacted, providing 1,032 data points from 2001 to 2020. Results: Over the survey period, 77% of the Ir-192 measurements used a well chamber instead of the older Krieger phantom method. Mean differences with the manufacturer calibration certificate were 0.01% +/- 1.15% for Ir-192 and -0.1% +/- 1.3% for Co-60. Over 95% of RAKR measurements in the clinic were within 3% of the manufacturer calibration certificate. Conclusions: This study showed that the agreement level was generally better than that reflected in prior societal recommendations positing 5%. Future recommendations on high-energy HDR and PDR source calibrations in the clinic may consider tightened agreements levels.
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Balbinot, R., & Fabbri, A. (2023). The Hawking Effect in the Particles-Partners Correlations. Physics, 5(4), 968–982.
Abstract: We analyze the correlations functions across the horizon in Hawking black hole radiation to reveal the correlations between Hawking particles and their partners. The effects of the underlying space-time on this are shown in various examples ranging from acoustic black holes to regular black holes.
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NEXT Collaboration(Henriques, C. A. O. et al), Benlloch-Rodriguez, J. M., Carcel, S., Carrion, J. V., Diaz, J., Felkai, R., et al. (2022). Neutral Bremsstrahlung Emission in Xenon Unveiled. Phys. Rev. X, 12(2), 021005–23pp.
Abstract: We present evidence of non-excimer-based secondary scintillation in gaseous xenon, obtained using both the NEXT-White time projection chamber (TPC) and a dedicated setup. Detailed comparison with first-principle calculations allows us to assign this scintillation mechanism to neutral bremsstrahlung (NBrS), a process that is postulated to exist in xenon that has been largely overlooked. For photon emission below 1000 nm, the NBrS yield increases from about 10(-2) photon/e(-) cm(-1) bar(-1) at pressure-reduced electric field values of 50 V cm(-1) bar(-1) to above 3 x 10(-1) photon/e(-) cm(-1) bar(-1) at 500 V cm(-1) bar(-1). Above 1.5 kV cm(-1) bar(-1), values that are typically employed for electroluminescence, it is estimated that NBrS is present with an intensity around 1 photon/e(-) cm(-1) bar(-1), which is about 2 orders of magnitude lower than conventional, excimer-based electroluminescence. Despite being fainter than its excimeric counterpart, our calculations reveal that NBrS causes luminous backgrounds that can interfere, in either gas or liquid phase, with the ability to distinguish and/or to precisely measure low primary-scintillation signals (S1). In particular, we show this to be the case in the "buffer region, where keeping the electric field below the electroluminescence threshold does not suffice to extinguish secondary scintillation. The electric field leakage in this region should be mitigated to avoid intolerable levels of NBrS emission. Furthermore, we show that this new source of light emission opens up a viable path toward obtaining S2 signals for discrimination purposes in future single-phase liquid TPCs for neutrino and dark matter physics, with estimated yields up to 20-50 photons/e(-) cm(-1).
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Karuseichyk, I., Sorelli, G., Walschaers, M., Treps, N., & Gessner, M. (2022). Resolving mutually-coherent point sources of light with arbitrary statistics. Phys. Rev. Res., 4(4), 043010–11pp.
Abstract: We analyze the problem of resolving two mutually coherent point sources with arbitrary quantum statistics, mutual phase, and relative and absolute intensity. We use a sensitivity measure based on the method of moments and compare direct imaging with spatial-mode demultiplexing (SPADE), analytically proving advantage of the latter. We show that the moment-based sensitivity of SPADE saturates the quantum Fisher information for all known cases, even for non-Gaussian states of the sources.
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Lasa-Alonso, J., Olmos-Trigo, J., Devescovi, C., Hernandez, P., Garcia-Etxarri, A., & Molina-Terriza, G. (2023). Resonant helicity mixing of electromagnetic waves propagating through matter. Phys. Rev. Res., 5(2), 023116–8pp.
Abstract: Dual scatterers preserve the helicity of an incident field, whereas antidual scatterers flip it completely. In this setting of linear electromagnetic scattering theory, we provide a completely general proof on the nonexistence of passive antidual scatterers. However, we show that scatterers fulfilling the refractive index matching condition flip the helicity of the fields very efficiently without being in contradiction with the law of energy conservation. Moreover, we find that this condition is paired with the impedance matching condition in several contexts of electromagnetism and, in particular, within Fresnel's and Mie's scattering problems. Finally, we show that indexmatched media induce a resonant helicity mixing on the propagating electromagnetic waves. We reach this conclusion by identifying that the refractive index matching condition leads to the phenomenon of avoided crossing.
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Das, B. et al, & Algora, A. (2024). Broken seniority symmetry in the semimagic proton mid-shell nucleus 95Rh. Phys. Rev. Res., 6(2), L022038–7pp.
Abstract: Lifetime measurements of low-lying excited states in the semimagic ( N = 50) nucleus 95 Rh have been performed by means of the fast -timing technique. The experiment was carried out using gamma -ray detector arrays consisting of LaBr 3 (Ce) scintillators and germanium detectors integrated into the DESPEC experimental setup commissioned for the Facility for Antiproton and Ion Research ( FAIR ) Phase -0, Darmstadt, Germany. The excited states in 95 Rh were populated primarily via the /3 decays of 95 Pd nuclei, produced in the projectile fragmentation of a 850 MeV / nucleon 124 Xe beam impinging on a 4 g / cm 2 9 Be target. The deduced electromagnetic E2 transition strengths for the gamma -ray cascade within the multiplet structure depopulating from the isomeric I pi = 21 / 2 + state are found to exhibit strong deviations from predictions of standard shell model calculations which feature approximately conserved seniority symmetry. In particular, the observation of a strongly suppressed E2 strength for the 13 / 2 + -> 9 / 2 + ground state transition cannot be explained by calculations employing standard interactions. This remarkable result may require revision of the nucleon-nucleon interactions employed in state-of-the-art theoretical model calculations, and might also point to the need for including three-body forces in the Hamiltonian.
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NEMO-3 Collaboration(Arnold R. et al), Martin-Albo, J., & Novella, P. (2011). Measurement of the beta beta Decay Half-Life of (130)Te with the NEMO-3 Detector. Physical Review Letters, 107(6), 062504.
Abstract: We report results from the NEMO-3 experiment based on an exposure of 1275 days with 661 g of (130)Te in the form of enriched and natural tellurium foils. The beta beta decay rate of (130)Te is found to be greater than zero with a significance of 7.7 standard deviations and the half-life is measured to be T(1/2)(2v)=[7.0 +/- 0.9(stat) +/- 1: 1(syst)] x 10(20) yr. This represents the most precise measurement of this half- life yet published and the first real-time observation of this decay.
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