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Author |
Angles-Castillo, A.; Bañuls, M.C.; Perez, A.; De Vega, I. |
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Title |
Prethermalization of quantum systems interacting with non-equilibrium environments |
Type |
Journal Article |
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Year |
2020 |
Publication  |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
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Volume |
22 |
Issue |
8 |
Pages |
083067 - 17pp |
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Keywords |
open quantum systems; prethermalization; master equations |
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Abstract |
The usual paradigm of open quantum systems falls short when the environment is actually coupled to additional fields or components that drive it out of equilibrium. Here we explore the simplest such scenario, by considering a two level system coupled to a first thermal reservoir that in turn couples to a second thermal bath at a different temperature. We derive a master equation description for the system and show that, in this situation, the dynamics can be especially rich. In particular, we observe prethermalization, a transitory phenomenon in which the system initially approaches thermal equilibrium with respect to the first reservoir, but after a longer time converges to the thermal state dictated by the temperature of the second environment. Using analytical arguments and numerical simulations, we analyze the occurrence of this phenomenon, and how it depends on temperatures and coupling strengths. The phenomenology gets even richer if the system is placed between two such non-equilibrium environments. In this case, the energy current through the system may exhibit transient features and even switch direction, before the system eventually reaches a non-equilibrium steady state. |
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Address |
[Angles-Castillo, Andreu; Perez, Armando] Univ Valencia, CSIC, Dept Fis Teor, Burjassot 46100, Valencia, Spain, Email: banulsm@mpq.mpg.de |
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Iop Publishing Ltd |
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English |
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1367-2630 |
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WOS:000565705900001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4525 |
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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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Notes |
WOS:001269841000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Norena, J.; Verde, L.; Jimenez, R.; Pena-Garay, C.; Gomez, C. |
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Title |
Cancelling out systematic uncertainties |
Type |
Journal Article |
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Year |
2012 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
419 |
Issue |
2 |
Pages |
1040-1050 |
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Keywords |
methods: statistical; cosmology: theory |
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Abstract |
We present a method to minimize, or even cancel out, the nuisance parameters affecting a measurement. Our approach is general and can be applied to any experiment or observation where systematic errors are a concern e.g. are larger than statistical errors. We compare it with the Bayesian technique used to deal with nuisance parameters: marginalization, and show how the method compares and improves by avoiding biases. We illustrate the method with several examples taken from the astrophysics and cosmology world: baryonic acoustic oscillations (BAOs), cosmic clocks, Type Ia supernova (SNIa) luminosity distance, neutrino oscillations and dark matter detection. By applying the method we not only recover some known results but also find some interesting new ones. For BAO experiments we show how to combine radial and angular BAO measurements in order to completely eliminate the dependence on the sound horizon at radiation drag. In the case of exploiting SNIa as standard candles we show how the uncertainty in the luminosity distance by a second parameter modelled as a metallicity dependence can be eliminated or greatly reduced. When using cosmic clocks to measure the expansion rate of the universe, we demonstrate how a particular combination of observables nearly removes the metallicity dependence of the galaxy on determining differential ages, thus removing the agemetallicity degeneracy in stellar populations. We hope that these findings will be useful in future surveys to obtain robust constraints on the dark energy equation of state. |
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Address |
[Norena, Jorge; Verde, Licia; Jimenez, Raul] Univ Barcelona IEEC UB, ICREA, Barcelona 08028, Spain, Email: jorge.norena@icc.ub.edu |
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Wiley-Blackwell |
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English |
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0035-8711 |
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Notes |
WOS:000298482300011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
890 |
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Author |
Villaescusa-Navarro, F.; Vogelsberger, M.; Viel, M.; Loeb, A. |
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Title |
Neutrino signatures on the high-transmission regions of the Lyman alpha forest |
Type |
Journal Article |
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Year |
2013 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
431 |
Issue |
4 |
Pages |
3670-3677 |
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Keywords |
neutrinos; intergalactic medium; quasars: absorption lines; cosmology: theory; large-scale structure of Universe |
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Abstract |
We quantify the impact of massive neutrinos on the statistics of low-density regions in the intergalactic medium as probed by the Lyman alpha forest at redshifts z = 2.2-4. Based on mock but realistic quasar (QSO) spectra extracted from hydrodynamic simulations with cold dark matter, baryons and neutrinos, we find that the probability distribution of weak Lyman alpha absorption features, as sampled by Lyman alpha flux regions at high transmissivity, is strongly affected by the presence of massive neutrinos. We show that systematic errors affecting the Lyman alpha forest reduce but do not erase the neutrino signal. Using the Fisher matrix formalism, we conclude that the sum of the neutrino masses can be measured, using the method proposed in this paper, with a precision smaller than 0.4 eV using a catalogue of 200 high-resolution (signal-to-noise ratio similar to 100) QSO spectra. This number reduces to 0.27 eV by making use of reasonable priors in the other parameters that also affect the statistics of the high-transitivity regions of the Lyman alpha forest. The constraints obtained with this method can be combined with independent bounds from the cosmic microwave background, large-scale structures and measurements of the matter power spectrum from the Lyman alpha forest to produce tighter upper limits on the sum of the masses of the neutrinos. |
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Address |
Univ Valencia, IFIC, CSIC, E-46071 Valencia, Spain, Email: viel@oats.inaf.it |
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Oxford Univ Press |
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English |
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0035-8711 |
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Notes |
WOS:000319479000057 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1458 |
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Author |
Vincent, A.C.; Scott, P.; Trampedach, R. |
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Title |
Light bosons in the photosphere and the solar abundance problem |
Type |
Journal Article |
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Year |
2013 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
432 |
Issue |
4 |
Pages |
3332-3339 |
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Keywords |
elementary particles; line: formation; Sun: abundances; Sun: atmosphere; cosmology: theory |
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Abstract |
Spectroscopy is used to measure the elemental abundances in the outer layers of the Sun, whereas helioseismology probes the interior. It is well known that current spectroscopic determinations of the chemical composition are starkly at odds with the metallicity implied by helioseismology. We investigate whether the discrepancy may be due to conversion of photons to a new light boson in the solar photosphere. We examine the impact of particles with axion-like interactions with the photon on the inferred photospheric abundances, showing that resonant axion-photon conversion is not possible in the region of the solar atmosphere in which line formation occurs. Although non-resonant conversion in the line-forming regions can in principle impact derived abundances, constraints from axion-photon conversion experiments rule out the couplings necessary for these effects to be detectable. We show that this extends to hidden photons and chameleons (which would exhibit similar phenomenological behaviour), ruling out known theories of new light bosons as photospheric solutions to the solar abundance problem. |
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Address |
[Vincent, A. C.] Univ Valencia, IFIC, CSIC, E-46071 Valencia, Spain, Email: vincent@ific.uv.es |
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Publisher |
Oxford Univ Press |
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English |
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0035-8711 |
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Notes |
WOS:000321053500058 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1481 |
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Author |
Moline, A.; Sanchez-Conde, M.A.; Palomares-Ruiz, S.; Prada, F. |
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Title |
Characterization of subhalo structural properties and implications for dark matter annihilation signals |
Type |
Journal Article |
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Year |
2017 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
466 |
Issue |
4 |
Pages |
4974-4990 |
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Keywords |
galaxies: haloes; cosmology: theory; dark matter |
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Abstract |
A prediction of the standard Lambda cold dark matter cosmology is that dark matter (DM) haloes are teeming with numerous self-bound substructure or subhaloes. The precise properties of these subhaloes represent important probes of the underlying cosmological model. We use data from Via Lactea II and Exploring the Local Volume in Simulations N-body simulations to learn about the structure of subhaloes with masses 10(6)-10(11) h(-1) M circle dot. Thanks to a superb subhalo statistics, we study subhalo properties as a function of distance to host halo centre and subhalo mass, and provide a set of fits that accurately describe the subhalo structure. We also investigate the role of subhaloes on the search for DM annihilation. Previous work has shown that subhaloes are expected to boost the DM signal of their host haloes significantly. Yet, these works traditionally assumed that subhaloes exhibit similar structural properties than those of field haloes, while it is known that subhaloes are more concentrated. Building upon our N-body data analysis, we refine the substructure boost model of Sanchez-Conde & Prada (2014), and find boosts that are a factor 2-3 higher. We further refine the model to include unavoidable tidal stripping effects on the subhalo population. For field haloes, this introduces a moderate (similar to 20-30 per cent) suppression. Yet, for subhaloes like those hosting dwarf galaxy satellites, tidal stripping plays a critical role, the boost being at the level of a few tens of percent at most. We provide a parametrization of the boost for field haloes that can be safely applied over a wide halo mass range. |
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Address |
[Moline, Angeles] Univ Tecn Lisboa, CFTP, Inst Super Tecn, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal, Email: angeles.moline@gmail.com; |
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Publisher |
Oxford Univ Press |
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English |
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0035-8711 |
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Notes |
WOS:000402849400088 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3164 |
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Author |
ANTARES and HESS Collaborations (Petroff, E. et al); Barrios-Marti, J.; Hernandez-Rey, J.J.; Illuminati, G.; Lotze, M.; Tönnis, C.; Zornoza, J.D.; Zuñiga, J. |
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Title |
A polarized fast radio burst at low Galactic latitude |
Type |
Journal Article |
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Year |
2017 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
469 |
Issue |
4 |
Pages |
4465-4482 |
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Keywords |
polarization; methods: data analysis; surveys; ISM: structure |
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Abstract |
We report on the discovery of a new fast radio burst (FRB), FRB 150215, with the Parkes radio telescope on 2015 February 15. The burst was detected in real time with a dispersion measure (DM) of 1105.6 +/- 0.8 pc cm(-3), a pulse duration of 2.8(-0.5)(+1.2) ms, and a measured peak flux density assuming that the burst was at beam centre of 0.7(-0.1)(+0.2) Jy. The FRB originated at a Galactic longitude and latitude of 24.66 degrees, 5.28 degrees and 25 degrees away from the Galactic Center. The burst was found to be 43 +/- 5 per cent linearly polarized with a rotation measure (RM) in the range -9 < RM < 12 rad m(-2) (95 per cent confidence level), consistent with zero. The burst was followed up with 11 telescopes to search for radio, optical, X-ray, gamma-ray and neutrino emission. Neither transient nor variable emission was found to be associated with the burst and no repeat pulses have been observed in 17.25 h of observing. The sightline to the burst is close to the Galactic plane and the observed physical properties of FRB 150215 demonstrate the existence of sight lines of anomalously low RM for a given electron column density. The Galactic RM foreground may approach a null value due to magnetic field reversals along the line of sight, a decreased total electron column density from the Milky Way, or some combination of these effects. A lower Galactic DM contribution might explain why this burst was detectable whereas previous searches at low latitude have had lower detection rates than those out of the plane. |
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Address |
[Petroff, E.; Rowlinson, A.] Netherlands Inst Radio Astron, ASTRON, Postbus 2, NL-7990 AA Dwingeloo, Netherlands |
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Publisher |
Oxford Univ Press |
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English |
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0035-8711 |
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Notes |
WOS:000406837900051 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3241 |
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Author |
ANTARES Collaboration (Bhandari, S. et al); Barrios-Marti, J.; Coleiro, A.; Hernandez-Rey, J.J.; Illuminati, G.; Tönnis, C.; Zornoza, J.D.; Zuñiga, J. |
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Title |
The SUrvey for Pulsars and Extragalactic Radio Bursts – II. New FRB discoveries and their follow-up |
Type |
Journal Article |
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Year |
2018 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
475 |
Issue |
2 |
Pages |
1427-1446 |
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Keywords |
radiation mechanisms: general; methods: data analysis; methods: observational; surveys; intergalactic medium; radio continuum: general |
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Abstract |
We report the discovery of four Fast Radio Bursts (FRBs) in the ongoing SUrvey for Pulsars and Extragalactic Radio Bursts at the Parkes Radio Telescope: FRBs 150610, 151206, 151230 and 160102. Our real-time discoveries have enabled us to conduct extensive, rapid multimessenger follow-up at 12 major facilities sensitive to radio, optical, X-ray, gamma-ray photons and neutrinos on time-scales ranging from an hour to a few months post-burst. No counterparts to the FRBs were found and we provide upper limits on afterglow luminosities. None of the FRBs were seen to repeat. Formal fits to all FRBs show hints of scattering while their intrinsic widths are unresolved in time. FRB 151206 is at low Galactic latitude, FRB 151230 shows a sharp spectral cut-off, and FRB 160102 has the highest dispersion measure (DM = 2596.1 +/- 0.3 pc cm(-3)) detected to date. Three of the FRBs have high dispersion measures (DM > 1500 pc cm(-3)), favouring a scenario where the DMis dominated by contributions from the intergalactic medium. The slope of the Parkes FRB source counts distribution with fluences > 2 Jy ms is alpha = – 2.2(-1.2)(+0.6) and still consistent with a Euclidean distribution (alpha = -3/2). We also find that the all-sky rate is 1.7(-0.9)(+1.5) x 10(3)FRBs/(4 pi sr)/day above similar to 2 Jy ms and there is currently no strong evidence for a latitude- dependent FRB sky rate. |
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Address |
[Bhandari, S.; Keane, E. F.; Barr, E. D.; Jameson, A.; Petroff, E.; Bailes, M.; Flynn, C.; Jankowski, F.; Krishnan, V. Venkatraman; Morello, V.; van Straten, W.; Andreoni, I.; Cooke, J.; Pritchard, T.] Swinburne Univ Technol, Ctr Astrophys & Supercomp, Mail H30,POB 218, Hawthorn, Vic 3122, Australia, Email: shivanibhandari58@gmail.com |
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Oxford Univ Press |
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English |
Summary Language |
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ISSN |
0035-8711 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000427345900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3518 |
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| Permanent link to this record |
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Author |
ANTARES Collaboration (Albert, A. et al); Barrios-Marti, J.; Coleiro, A.; Colomer, M.; Hernandez-Rey, J.J.; Illuminati, G.; Lotze, M.; Zornoza, J.D.; Zuñiga, J. |
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Title |
The search for high-energy neutrinos coincident with fast radio bursts with the ANTARES neutrino telescope |
Type |
Journal Article |
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Year |
2019 |
Publication |
Monthly Notices of the Royal Astronomical Society |
Abbreviated Journal |
Mon. Not. Roy. Astron. Soc. |
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Volume |
482 |
Issue |
1 |
Pages |
184-193 |
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Keywords |
acceleration of particles; neutrinos; astroparticle physics; radio continuum: transients; methods: data analysis |
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Abstract |
In the past decade, a new class of bright transient radio sources with millisecond duration has been discovered. The origin of these so-called fast radio bursts (FRBs) is still a mystery, despite the growing observational efforts made by various multiwavelength and multimessenger facilities. To date, many models have been proposed to explain FRBs, but neither the progenitors nor the radiative and the particle acceleration processes at work have been clearly identified. In this paper, we assess whether hadronic processes may occur in the vicinity of the FRB source. If they do, FRBs may contribute to the high-energy cosmic-ray and neutrino fluxes. A search for these hadronic signatures was carried out using the ANTARES neutrino telescope. The analysis consists in looking for high-energy neutrinos, in the TeV-PeV regime, that are spatially and temporally coincident with the detected FRBs. Most of the FRBs discovered in the period 2013-2017 were in the field of view of the ANTARES detector, which is sensitive mostly to events originating from the Southern hemisphere. From this period, 12 FRBs were selected and no coincident neutrino candidate was observed. Upper limits on the per-burst neutrino fluence were derived using a power-law spectrum, dN/DE nu proportional to E-nu(-gamma), for the incoming neutrino flux, assuming spectral indexes gamma = 1.0, 2.0, 2.5. Finally, the neutrino energy was constrained by computing the total energy radiated in neutrinos, assuming different distances for the FRBs. Constraints on the neutrino fluence and on the energy released were derived from the associated null results. |
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Address |
[Turpin, D.] Chinese Acad Sci, Natl Astron Observ, Key Lab Space Astron & Technol, Beijing 100101, Peoples R China, Email: dornic@cppm.in2p3.fr; |
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Publisher |
Oxford Univ Press |
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English |
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0035-8711 |
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WOS:000454575300014 |
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IFIC @ pastor @ |
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3860 |
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Author |
Gammaldi, V.; Zaldivar, B.; Sanchez-Conde, M.A.; Coronado-Blazquez, J. |
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A search for dark matter among Fermi-LAT unidentified sources with systematic features in machine learning |
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2023 |
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Monthly Notices of the Royal Astronomical Society |
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Mon. Not. Roy. Astron. Soc. |
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520 |
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1 |
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1348-1361 |
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astroparticle physics – methods; data analysis – methods; observational – methods; statistical – dark matter – gamma-rays; general |
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Abstract |
Around one-third of the point-like sources in the Fermi-LAT catalogues remain as unidentified sources (unIDs) today. Indeed, these unIDs lack a clear, univocal association with a known astrophysical source. If dark matter (DM) is composed of weakly interacting massive particles (WIMPs), there is the exciting possibility that some of these unIDs may actually be DM sources, emitting gamma-rays from WIMPs annihilation. We propose a new approach to solve the standard, machine learning (ML) binary classification problem of disentangling prospective DM sources (simulated data) from astrophysical sources (observed data) among the unIDs of the 4FGL Fermi-LAT catalogue. We artificially build two systematic features for the DM data which are originally inherent to observed data: the detection significance and the uncertainty on the spectral curvature. We do it by sampling from the observed population of unIDs, assuming that the DM distributions would, if any, follow the latter. We consider different ML models: Logistic Regression, Neural Network (NN), Naive Bayes, and Gaussian Process, out of which the best, in terms of classification accuracy, is the NN, achieving around 93 . 3 per cent +/- 0 . 7 per cent performance. Other ML evaluation parameters, such as the True Ne gativ e and True Positive rates, are discussed in our work. Applying the NN to the unIDs sample, we find that the de generac y between some astrophysical and DM sources can be partially solved within this methodology. None the less, we conclude that there are no DM source candidates among the pool of 4FGL Fermi-LAT unIDs. |
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[Gammaldi, V; Sanchez-Conde, M. A.; Coronado-Blazquez, J.] Univ Autonoma Madrid, Departamentode Fis Teor, E-28049 Madrid, Spain, Email: viviana.gammaldi@uam.es; |
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Oxford Univ Press |
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English |
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0035-8711 |
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WOS:000937053400014 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5489 |
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