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Author Llosa, G.; Trovato, M.; Barrio, J.; Etxebeste, A.; Muñoz, E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Solevi, P. doi  openurl
  Title First Images of a Three-layer compton Telescope prototype for Treatment Monitoring in hadron Therapy Type Journal Article
  Year 2016 Publication (up) Frontiers in Oncology Abbreviated Journal Front. Oncol.  
  Volume 6 Issue Pages 14 - 6pp  
  Keywords Compton camera; Compton telescope; hadron therapy; treatment monitoring; LaBr3  
  Abstract A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers of LaBr3 crystals coupled to silicon photomulti-plier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary for the prototype operation at low coincidence rates. A spatial resolution of 7.8 mm FWHM has been obtained in the first imaging tests.  
  Address [Llosa, Gabriela; Trovato, Marco; Barrio, John; Etxebeste, Ane; Munoz, Enrique; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Solaz, Carles; Solevi, Paola] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: gabriela.llosa@ific.uv.es  
  Corporate Author Thesis  
  Publisher Frontiers Media Sa Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2234-943x ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000369799800001 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ elepoucu @ Serial 2785  
Permanent link to this record
 

 
Author Tetrault, M.A.; Oliver, J.F.; Bergeron, M.; Lecomte, R.; Fontaine, R. doi  openurl
  Title Real Time Coincidence Detection Engine for High Count Rate Timestamp Based PET Type Journal Article
  Year 2010 Publication (up) IEEE Transactions on Nuclear Science Abbreviated Journal IEEE Trans. Nucl. Sci.  
  Volume 57 Issue 1 Pages 117-124  
  Keywords Coincidence detection; Positron Emission Tomography (PET)  
  Abstract Coincidence engines follow two main implementation flows: timestamp based systems and AND-gate based systems. The latter have been more widespread in recent years because of its lower cost and high efficiency. However, they are highly dependent on the selected electronic components, they have limited flexibility once assembled and they are customized to fit a specific scanner's geometry. Timestamp based systems are gathering more attention lately, especially with high channel count fully digital systems. These new systems must however cope with important singles count rates. One option is to record every detected event and postpone coincidence detection offline. For daily use systems, a real time engine is preferable because it dramatically reduces data volume and hence image preprocessing time and raw data management. This paper presents the timestamp based coincidence engine for the LabPET(TM), a small animal PET scanner with up to 4608 individual readout avalanche photodiode channels. The engine can handle up to 100 million single events per second and has extensive flexibility because it resides in programmable logic devices. It can be adapted for any detector geometry or channel count, can be ported to newer, faster programmable devices and can have extra modules added to take advantage of scanner-specific features. Finally, the user can select between full processing mode for imaging protocols and minimum processing mode to study different approaches for coincidence detection with offline software.  
  Address [Tetrault, M. -A.; Fontaine, R.] Univ Sherbrooke, Dept Elect & Comp Engn, Sherbrooke, PQ J1K 2R1, Canada, Email: Marc-Andre.Tetrault@USherbrooke.ca  
  Corporate Author Thesis  
  Publisher Ieee-Inst Electrical Electronics Engineers Inc Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0018-9499 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000274391000016 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ elepoucu @ Serial 500  
Permanent link to this record
 

 
Author Oliver, J.F.; Fuster-Garcia, E.; Cabello, J.; Tortajada, S.; Rafecas, M. doi  openurl
  Title Application of Artificial Neural Network for Reducing Random Coincidences in PET Type Journal Article
  Year 2013 Publication (up) IEEE Transactions on Nuclear Science Abbreviated Journal IEEE Trans. Nucl. Sci.  
  Volume 60 Issue 5 Pages 3399-3409  
  Keywords  
  Abstract Positron Emission Tomography (PET) is based on the detection in coincidence of the two photons created in a positron annihilation. In conventional PET, this coincidence identification is usually carried out through a coincidence electronic unit. An accidental coincidence occurs when two photons arising from different annihilations are classified as a coincidence. Accidental coincidences are one of the main sources of image degradation in PET. Some novel systems allow coincidences to be selected post-acquisition in software, or in real time through a digital coincidence engine in an FPGA. These approaches provide the user with extra flexibility in the sorting process and allow the application of alternative coincidence sorting procedures. In this work a novel sorting procedure based on Artificial Neural Network (ANN) techniques has been developed. It has been compared to a conventional coincidence sorting algorithm based on a time coincidence window. The data have been obtained from Monte-Carlo simulations. A small animal PET scanner has been implemented to this end. The efficiency (the ratio of correct identifications) can be selected for both methods. In one case by changing the actual value of the coincidence window used, and in the other by changing a threshold at the output of the neural network. At matched efficiencies, the ANN-based method always produces a sorted output with a smaller random fraction. In addition, two differential trends are found: the conventional method presents a maximum achievable efficiency, while the ANN-based method is able to increase the efficiency up to unity, the ideal value, at the cost of increasing the random fraction. Images reconstructed using ANN sorted data (no compensation for randoms) present better contrast, and those image features which are more affected by randoms are enhanced. For the image quality phantom used in the paper, the ANN method decreases the spill-over ratio by a factor of 18%.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0018-9499 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000325827200027 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1611  
Permanent link to this record
 

 
Author Barrio, J.; Etxebeste, A.; Lacasta, C.; Muñoz, E.; Oliver, J.F.; Solaz, C.; Llosa, G. doi  openurl
  Title Performance of VATA64HDR16 ASIC for medical physics applications based on continuous crystals and SiPMs Type Journal Article
  Year 2015 Publication (up) Journal of Instrumentation Abbreviated Journal J. Instrum.  
  Volume 10 Issue Pages P12001 - 12pp  
  Keywords Solid state detectors; Photon detectors for UV, visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs etc); Front-end electronics for detector readout; Gamma detectors (scintillators, CZT, HPG, HgI etc)  
  Abstract Detectors based on Silicon Photomultipliers (SiPMs) coupled to continuous crystals are being tested in medical physics applications due to their potential high resolution and sensitivity. To cope with the high granularity required for a very good spatial resolution, SiPM matrices with a large amount of elements are needed. To be able to read the information coming from each individual channel, dedicated ASICs are employed. The VATA64HDR16 ASIC is a 64-channel, charge-sensitive amplifier that converts the collected charge into a proportional current or voltage signal. A complete assessment of the suitability of that ASIC for medical physics applications based on continuous crystals and SiPMs has been carried out. The input charge range is linear from 20 pC up to 55 pC. The energy resolution obtained at 511 keV is 10% FWHM with a LaBr3 crystal and 16% FWHM with a LYSO crystal. A coincidence timing resolution of 24 ns FWHM is obtained with two LYSO crystals.  
  Address [Barrio, J.; Etxebeste, A.; Lacasta, C.; Munoz, E.; Oliver, J. F.; Solaz, C.; Llosa, G.] Univ Valencia, CSIC, Inst Fis Corpuscular, Parque Cient,C Catedrat Jose Beltran 2, E-46980 Paterna, Spain, Email: John.Barrio@ific.uv.es  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1748-0221 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000369998500034 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 2548  
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Author Brzezinski, K.; Oliver, J.F.; Gillam, J.; Rafecas, M.; Studen, A.; Grkovski, M.; Kagan, H.; Smith, S.; Llosa, G.; Lacasta, C.; Clinthorne, N.H. doi  openurl
  Title Experimental evaluation of the resolution improvement provided by a silicon PET probe Type Journal Article
  Year 2016 Publication (up) Journal of Instrumentation Abbreviated Journal J. Instrum.  
  Volume 11 Issue Pages P09016 - 13pp  
  Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Medical-image reconstruction methods and algorithms; computer-aided software  
  Abstract A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously shown that the additional probe information improves the spatial resolution of the reconstructed image and increases lesion detectability, with no cost to other image quality measures. The current study expands on the previous work by using a laboratory prototype of the silicon PET-probe system to examine the resolution improvement in an experimental setting. Two different versions of the probe prototype were assessed, both consisting of a back-to-back pair of 1-mm thick silicon pad detectors, one arranged in 32 x 16 arrays of 1.4mm x 1.4mm pixels and the other in 40 x 26 arrays of 1.0mm x 1.0mm pixels. Each detector was read out by a set of VATAGP7 ASICs and a custom-designed data acquisition board which allowed trigger and data interfacing with the PET scanner, itself consisting of BGO block detectors segmented into 8 x 6 arrays of 6mm x 12mm x 30mm crystals. Limited-angle probe data was acquired from a group of Na-22 point-like sources in order to observe the maximum resolution achievable using the probe system. Data from a Derenzo-like resolution phantom was acquired, then scaled to obtain similar statistical quality as that of previous simulation studies. In this case, images were reconstructed using measurements of the PET ring alone and with the inclusion of the probe data. Images of the Na-22 source demonstrated a resolution of 1.5mm FWHM in the probe data, the PET ring resolution being approximately 6 mm. Profiles taken through the image of the Derenzo-like phantom showed a clear increase in spatial resolution. Improvements in peak-to-valley ratios of 50% and 38%, in the 4.8mm and 4.0mm phantom features respectively, were observed, while previously unresolvable 3.2mm features were brought to light by the addition of the probe. These results support the possibility of improving the image resolution of a clinical PET scanner using the silicon PET-probe.  
  Address [Brzezinski, K.; Oliver, J. F.; Gillam, J.; Rafecas, M.; Llosa, G.; Lacasta, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Valencia, Spain, Email: k.w.brzezinski@rug.nl  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1748-0221 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000387862300016 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 2865  
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