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Otal, A., Celada, F., Chimeno, J., Vijande, J., Pellejero, S., Perez-Calatayud, M. J., et al. (2022). Review on Treatment Planning Systems for Cervix Brachytherapy (Interventional Radiotherapy): Some Desirable and Convenient Practical Aspects to Be Implemented from Radiation Oncologist and Medical Physics Perspectives. Cancers, 14(14), 3467–15pp.
Abstract: Simple Summary There are no brachytherapy treatment planning systems (TPS) exclusively for the treatment of cervical tumours, so general-purpose TPSs are used. However, these treatments have some particular features concerning the treatment of other pathologies, especially in the case of exclusive use of MRI as an imaging modality and the presence of gynaecological applicators in combination with an interstitial part. That is why it is essential to review the latest versions of commercial TPSs to find the potential features to improve with the help of a group of experimented medical physicists and radiation oncologists. Furthermore, after reviewing the recent literature for advances applicable to cervical brachytherapy and through his own clinical experience, possible improvements are proposed to software providers for the development of new tools. Intracavitary brachytherapy (BT, Interventional Radiotherapy, IRT), plays an essential role in the curative intent of locally advanced cervical cancer, for which the conventional approach involves external beam radiotherapy with concurrent chemotherapy followed by BT. This work aims to review the different methodologies used by commercially available treatment planning systems (TPSs) in exclusive magnetic resonance imaging-based (MRI) cervix BT with interstitial component treatments. Practical aspects and improvements to be implemented into the TPSs are discussed. This review is based on the clinical expertise of a group of radiation oncologists and medical physicists and on interactive demos provided by the software manufacturers. The TPS versions considered include all the new tools currently in development for future commercial releases. The specialists from the supplier companies were asked to propose solutions to some of the challenges often encountered in a clinical environment through a questionnaire. The results include not only such answers but also comments by the authors that, in their opinion, could help solve the challenges covered in these questions. This study summarizes the possibilities offered nowadays by commercial TPSs, highlighting the absence of some useful tools that would notably improve the planning of MR-based interstitial component cervix brachytherapy.
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Mandal, S., Miranda, O. G., Sanchez Garcia, G., Valle, J. W. F., & Xu, X. J. (2022). High-energy colliders as a probe of neutrino properties. Phys. Lett. B, 829, 137110–5pp.
Abstract: The mediators of neutrino mass generation can provide a probe of neutrino properties at the next round of high-energy hadron (FCC-hh) and lepton colliders (FCC-ee/ILC/CEPC/CLIC). We show how the decays of the Higgs triplet scalars mediating the simplest seesaw mechanism can shed light on the neutrino mass scale and mass-ordering, as well as the atmospheric octant. Four-lepton signatures at the high-energy frontier may provide the discovery-site for charged lepton flavor non-conservation in nature, rather than low-energy intensity frontier experiments.
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Pich, A., & Rodriguez-Sanchez, A. (2022). Violations of quark-hadron duality in low-energy determinations of alpha(s). J. High Energy Phys., 07(7), 145–42pp.
Abstract: Using the spectral functions measured in tau decays, we investigate the actual numerical impact of duality violations on the extraction of the strong coupling. These effects are tiny in the standard alpha(s)(m(tau)(2)) determinations from integrated distributions of the hadronic spectrum with pinched weights, or from the total tau hadronic width. The pinched-weight factors suppress very efficiently the violations of duality, making their numerical effects negligible in comparison with the larger perturbative uncertainties. However, combined fits of alpha(s) and duality-violation parameters, performed with non-protected weights, are subject to large systematic errors associated with the assumed modelling of duality-violation effects. These uncertainties have not been taken into account in the published analyses, based on specific models of quark-hadron duality.
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SCiMMA and SNEWS Collaborations(Baxter, A. L. et al), & Colomer, M. (2022). Collaborative experience between scientific software projects using Agile Scrum development. Softw.-Pract. Exp., 52, 2077–2096.
Abstract: Developing sustainable software for the scientific community requires expertise in software engineering and domain science. This can be challenging due to the unique needs of scientific software, the insufficient resources for software engineering practices in the scientific community, and the complexity of developing for evolving scientific contexts. While open-source software can partially address these concerns, it can introduce complicating dependencies and delay development. These issues can be reduced if scientists and software developers collaborate. We present a case study wherein scientists from the SuperNova Early Warning System collaborated with software developers from the Scalable Cyberinfrastructure for Multi-Messenger Astrophysics project. The collaboration addressed the difficulties of open-source software development, but presented additional risks to each team. For the scientists, there was a concern of relying on external systems and lacking control in the development process. For the developers, there was a risk in supporting a user-group while maintaining core development. These issues were mitigated by creating a second Agile Scrum framework in parallel with the developers' ongoing Agile Scrum process. This Agile collaboration promoted communication, ensured that the scientists had an active role in development, and allowed the developers to evaluate and implement the scientists' software requirements. The collaboration provided benefits for each group: the scientists actuated their development by using an existing platform, and the developers utilized the scientists' use-case to improve their systems. This case study suggests that scientists and software developers can avoid scientific computing issues by collaborating and that Agile Scrum methods can address emergent concerns.
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Addazi, A. et al, Martinez-Mirave, P., Mitsou, V. A., Palomares-Ruiz, S., Tortola, M., & Zornoza, J. D. (2022). Quantum gravity phenomenology at the dawn of the multi-messenger era-A review. Prog. Part. Nucl. Phys., 125, 103948–119pp.
Abstract: The exploration of the universe has recently entered a new era thanks to the multi-messenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 “Quantum gravity phenomenology in the multi-messenger approach”, is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers.
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