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Author |
Oliver, S.; Vijande, J.; Tejedor-Aguilar, N.; Miro, R.; Rovira-Escutia, J.J.; Ballester, F.; Juste, B.; Carmona, V.; Felici, G.; Verdu, G.; Sanchis, E.; Conde, A.; Perez-Calatayud, J. |
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Title |
Monte Carlo flattening filter design to high energy intraoperative electron beam homogenization |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
212 |
Issue |
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Pages |
111102 - 6pp |
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Keywords |
Intraoperative radiotherapy; Electron portable LinAc; Flattening filter; Dosimetry; Monte Carlo |
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Abstract |
Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice. |
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Address |
[Oliver, S.; Miro, R.; Juste, B.; Verdu, G.] Univ Polite cn Vale ncia, Inst Segur Ind Radiofis & Medioambiental ISIRYM, Cami Vera S-N, Valencia 46022, Spain, Email: gverdu@iqn.upv.es |
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Publisher |
Pergamon-Elsevier Science Ltd |
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Language |
English |
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ISSN |
0969-806x |
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Conference |
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Notes  |
WOS:001026194900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5578 |
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Author |
Fadel, M.; Yadin, B.; Mao, Y.P.; Byrnes, T.; Gessner, M. |
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Title |
Multiparameter quantum metrology and mode entanglement with spatially split nonclassical spin ensembles |
Type |
Journal Article |
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Year |
2023 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
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Volume |
25 |
Issue |
7 |
Pages |
073006 - 25pp |
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Keywords |
quantum metrology; Bose-Einstein condensates; spin-squeezing; Fisher information matrix; mode and particle entanglement |
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Abstract |
We identify the multiparameter sensitivity of entangled spin states, such as spin-squeezed and Dicke states that are spatially distributed into several addressable spatial modes. Analytical expressions for the spin-squeezing matrix of families of states that are accessible by current atomic experiments reveal the quantum gain in multiparameter metrology, as well as the optimal strategies to maximize the sensitivity gain for the estimation of any linear combination of parameters. We further study the mode entanglement of these states by deriving a witness for genuine k-partite mode entanglement from the spin-squeezing matrix. Our results highlight the advantage of mode entanglement for distributed sensing, and outline optimal protocols for multiparameter estimation with nonclassical spatially-distributed spin ensembles. We illustrate our findings with the design of a protocol for gradient sensing with a Bose-Einstein condensate in an entangled spin state in two modes. |
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Address |
[Fadel, Matteo] Swiss Fed Inst Technol, Dept Phys, CH-8093 Zurich, Switzerland, Email: fadelm@phys.ethz.ch; |
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Publisher |
IOP Publishing Ltd |
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English |
Summary Language |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1367-2630 |
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Conference |
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Notes |
WOS:001026518600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5582 |
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Author |
Brzezinski, K. et al |
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Title |
Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
145016 - 17pp |
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Keywords |
proton therapy; positron emission tomography; in vivo range verification; J-PET; Monte Carlo |
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Abstract |
Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. |
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Address |
[Brzezinski, Karol; Gajewski, Jan; Kopec, Renata; Olko, Pawel; Stasica, Paulina; Rucinski, Antoni] Polish Acad Sci, Inst Nucl Phys, Krakow, Poland, Email: karol.brzezinski@ific.uv.es |
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Corporate Author |
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Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9155 |
ISBN |
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Conference |
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Notes |
WOS:001026535700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5616 |
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Author |
Beaulieu, L.; Ballester, F.; Granero, D.; Tedgren, A.C.; Haworth, A.; Lowenstein, J.R.; Ma, Y.Z.; Mourtada, F.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; Sloboda, R.S.; Smith, R.L.; Thomson, R.M.; Verhaegen, F.; Fonseca, G.; Vijande, J. |
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Title |
AAPM WGDCAB Report 372: A joint AAPM, ESTRO, ABG, and ABS report on commissioning of model-based dose calculation algorithms in brachytherapy |
Type |
Journal Article |
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Year |
2023 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
50 |
Issue |
8 |
Pages |
e946–e960 |
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Keywords |
brachytherapy; commissioning; dose calculation; model-based dose calculation; Monte Carlo; TG-186 |
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Abstract |
The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged. |
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Address |
[Beaulieu, Luc; Ma, Yunzhi] CHU Quebec Univ Laval, Serv Phys Med & Radioprotect, Quebec City, PQ, Canada, Email: beaulieu@phy.ulaval.ca |
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Publisher |
Wiley |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:001026540300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5579 |
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Author |
Abreu, L.M.; Dai, L.R.; Oset, E. |
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Title |
J/Psi decay to omega, phi, K*0 plus f0(1370), f0(1710), K0*(1430), f2(1270), f'2 (1525) and K2*(1430): Role of the D-wave for tensor production |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
843 |
Issue |
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Pages |
137999 - 10pp |
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Keywords |
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Abstract |
We reassess the decay of the J/Psi into an omega, phi, K*0 and one of the f0(1370), f0(1710), f2(1270), f'2 (1525), K0*(1430) and K2*(1430) resonances. We benefit from previous works that considered this reaction as a J/Psi decay into three vector mesons, with a scalar or tensor resonance being formed from the interaction of two of these vectors. The novelty here with respect to former studies is the investigation of the relation between the scalar meson and tensor productions for the first time. To this end, the spin structure of the four vectors present in the production vertex is analyzed, and the D-wave mechanism in the tensor production is included. Then, beyond the ratios studied previously involving scalar states and tensor states independently, new ratios relating the scalar and tensor meson productions are estimated. Our results suggest that the D-wave mechanism of tensor production assumes a relevant contribution. New experimental data reporting the angular distributions of these processes will be important for checking this conclusion. |
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Address |
[Abreu, Luciano M.] Univ Fed Bahia, Inst Fis, Campus Univ Ondina, BR-40170115 Salvador, BA, Brazil, Email: luciano.abreu@ufba.br; |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001027532500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5574 |
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