Abstract: Purpose: In skin high-dose-rate (HDR) brachytherapy, sources are located outside, in contact with, or implanted at some depth below the skin surface. Most treatment planning systems use the TG-43 formalism, which is based on single-source dose superposition within an infinite water medium without accounting for the true geometry in which conditions for scattered radiation are altered by the presence of air. The purpose of this study is to evaluate the dosimetric limitations of the TG-43 formalism in HDR skin brachytherapy and the potential clinical impact. Methods: Dose rate distributions of typical configurations used in skin brachytherapy were obtained: a 5 cm x 5 cm superficial mould; a source inside a catheter located at the skin surface with and without backscatter bolus; and a typical interstitial implant consisting of an HDR source in a catheter located at a depth of 0.5 cm. Commercially available HDR Co-60 and Ir-192 sources and a hypothetical Yb-169 source were considered. The Geant4Monte Carlo radiation transport code was used to estimate dose rate distributions for the configurations considered. These results were then compared to those obtained with the TG-43 dose calculation formalism. In particular, the influence of adding bolus material over the implant was studied. Results: For a 5 cm x 5 cm Ir-192 superficial mould and 0.5 cm prescription depth, dose differences in comparison to the TG-43 method were about -3%. When the source was positioned at the skin surface, dose differences were smaller than -1% for Co-60 and Ir-192, yet -3% for Yb-169. For the interstitial implant, dose differences at the skin surface were -7% for Co-60, -0.6% for Ir-192, and -2.5% for Yb-169. Conclusions: This study indicates the following: (i) for the superficial mould, no bolus is needed; (ii) when the source is in contact with the skin surface, no bolus is needed for either Co-60 and Ir-192. For lower energy radionuclides like Yb-169, bolus may be needed; and (iii) for the interstitial case, at least a 0.1 cm bolus is advised for Co-60 to avoid underdosing superficial target layers. For Ir-192 and Yb-169, no bolus is needed. For those cases where no bolus is needed, its use might be detrimental as the lack of radiation scatter may be beneficial to the patient, although the 2% tolerance for dose calculation accuracy recommended in the AAPM TG-56 report is not fulfilled.

Abstract: We develop a method to determine accurately the binding energy of the X( 3872) from lattice data for the D (D) over bar* interaction. We show that, because of the small difference between the neutral and charged components of the X( 3872), it is necessary to differentiate them in the energy levels of the lattice spectrum if one wishes to have a precise determination of the the binding energy of the X( 3872). The analysis of the data requires the use of coupled channels. Depending on the number of levels available and the size of the box, we determine the precision needed in the lattice energies to finally obtain a desired accuracy in the binding energy.

Abstract: It has been pointed out recently that current low-energy constraints still allow for sizable flavor-changing decay rates of the 125 GeV boson into leptons, h -> tau l (l = e, mu). In this work we discuss the role of hadronic tau-lepton decays in probing lepton flavor violating couplings in the Higgs sector. At low energy, the effective Higgs coupling to gluons induced by heavy quarks contributes to hadronic tau decays, establishing a direct connection with the relevant process at the LHC, pp(gg) -> h -> tau l. Semileptonic transitions like tau -> l pi pi are sensitive to flavor-changing scalar couplings, while decays such as tau -> l eta((l)) probe pseudoscalar couplings, thus providing a useful low-energy handle to disentangle possible Higgs flavor violating signals at the LHC. As part of our analysis, we provide an appropriate description of all the relevant hadronic matrix elements needed to describe Higgs mediated tau -> pi pi transitions, improving over previous treatments in the literature.

Abstract: In this paper we study the reaction e(+)e(-) -> (D*(D*) over bar (+/-)pi(-/+) in which the BESIII collaboration has claimed the existence of a 1(+) resonance, named Z(c)(4025), in the (D*(D*) over bar invariant mass spectrum with a mass around 4026 MeV and width close to 26 MeV. We determine the (D*(D*) over bar invariant mass distribution and find that although the explanation considered by the BESIII collaboration is plausible, there are others which are equally possible, like a 2(+) resonance or a bound state. Even more, we find that the data can be explained without the existence of a resonance/bound state. In view of the different possible interpretations found for the BESIII data, we try to devise a strategy which could help in identifying the origin of the signal reported by the BESIII collaboration. For this, we study the dependence of the (D*(D*) over bar spectrum considering the different options as a function of the total center-of-mass energy. We arrive at the conclusion that increasing the center-of-mass energy from 4.26 GeV to 4.6 GeV can be useful to distinguish between a resonance, a bound state or just a pure background as being responsible for the signal found. This information should be useful for future experiments.

Abstract: We construct a comprehensive list of nonsupersymmetric standard model extensions with a low-scale left-right (LR)-symmetric intermediate stage that may be obtained as simple low-energy effective theories within a class of renormalizable SO(10) grand unified theories. Unlike the traditional “minimal” LR models many of our example settings support a perfect gauge coupling unification even if the LR scale is in the LHC domain at a price of only (a few copies of) one or two types of extra fields pulled down to the TeV-scale ballpark. We discuss the main aspects of a potentially realistic model building conforming the basic constraints from the quark and lepton sector flavor structure, proton decay limits, etc. We pay special attention to the theoretical uncertainties related to the limited information about the underlying unified framework in the bottom-up approach, in particular, to their role in the possible extraction of the LR-breaking scale. We observe a general tendency for the models without new colored states in the TeV domain to be on the verge of incompatibility with the proton stability constraints.