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Author |
Llosa, G.; Barrillon, P.; Barrio, J.; Bisogni, M.G.; Cabello, J.; Del Guerra, A.; Etxebeste, A.; Gillam, J.E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Stankova, V.; de La Taille, C. |
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Title |
High performance detector head for PET and PET/MR with continuous crystals and SiPMs |
Type |
Journal Article |
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Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
702 |
Issue |
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Pages |
3-5 |
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Keywords |
Monolithic crystals; SiPM; MG-APD; PET; High resolution; Position determination |
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Abstract |
A high resolution PET detector head for small animal PET applications has been developed. The detector is composed of a 12 mm x 12 mm continuous LYSO crystal coupled to a 64-channel monolithic SiPM matrix from FBK-irst. Crystal thicknesses of 5 mm and 10 mm have been tested, both yielding an intrinsic spatial resolution around 0.7 mm FWHM with a position determination algorithm that can also provide depth-of-interaction information. The detectors have been tested in a rotating system that makes it possible to acquire tomographic data and reconstruct images of Na-22 sources. An image reconstruction method specifically adapted for continuous crystals has been employed. The Full Width at Half Maximum measured from a point source reconstructed with ML-EM was 0.7 mm with the 5 mm crystal and 0.8 mm with the 10 mm crystal. |
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Address |
[Llosa, G.; Barrio, J.; Cabello, J.; Etxebeste, A.; Gillam, J. E.; Lacasta, C.; Oliver, J. F.; Rafecas, M.; Solaz, C.; Stankova, V.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
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Publisher |
Elsevier Science Bv |
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Language |
English |
Summary Language |
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Edition |
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ISSN |
0168-9002 |
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Conference |
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Notes  |
WOS:000314682300002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1330 |
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Author |
Cabello, J.; Etxebeste, A.; Llosa, G.; Ziegler, S.I. |
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Title |
Simulation study of PET detector limitations using continuous crystals |
Type |
Journal Article |
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Year |
2015 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
60 |
Issue |
9 |
Pages |
3673-3694 |
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Keywords |
continuous crystals; parallax effects; depth of interaction; high resolution; small animal PET |
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Abstract |
Continuous crystals can potentially obtain better intrinsic detector spatial resolution compared to pixelated crystals, additionally providing depth of interaction (DoI) information from the light distribution. To achieve high performance sophisticated interaction position estimation algorithms are required. There are a number of algorithms in the literature applied to different crystal dimensions and different photodetectors. However, the different crystal properties and photodetector array geometries have an impact on the algorithm performance. In this work we analysed, through Monte Carlo simulations, different combinations of realistic crystals and photodetector parameters to better understand their influence on the interaction position estimation accuracy, with special emphasis on the DoI. We used an interaction position estimation based on an analytical model for the present work. Different photodetector granulation schemes were investigated. The impact of the number of crystal faces readout by photodetectors was studied by simulating scenarios with one and two photodetectors. In addition, crystals with different levels of reflection and aspect ratios (AR) were analysed. Results showed that the impact of photodetector granularity is mainly shown near the edges and specially in the corners of the crystal. The resulting intrinsic spatial resolution near the centre with a 12 x 12 x 10 mm(3) LYSO crystal was 0.7-0.9 mm, while the average spatial resolution calculated on the entire crystal was 0.77 +/- 0.18 mm for all the simulated geometries with one and two photodetectors. Having front and back photodetectors reduced the DoI bias (Euclidean distance between estimated DoI and real DoI) and improved the transversal resolution near the corners. In scenarios with one photodetector, small AR resulted in DoI inaccuracies for absorbed events at the entrance of the crystal. These inaccuracies were slightly reduced either by increasing the AR or reducing the amount of reflected light, and highly mitigated using two photodetectors. Using one photodetector, we obtained a piecewise DoI error model with a DoI resolution of 0.4-0.9 mm for a 1.2 AR crystal, and we observed that including a second photodetector or reducing the amount of reflections reduced the DoI bias but did not significantly improve the DoI resolution. Translating the piecewise DoI error model obtained in this study to image reconstruction we obtained a spatial resolution variability of 0.39 mm using 85% of the FoV, compared to 2.59 mm and 1.87 mm without DoI correction or with a dual layer system, respectively. |
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Address |
[Cabello, Jorge; Ziegler, Sibylle I.] Tech Univ Munich, Klinikum Rechts Isar, Nukl Med Klin & Poliklin, D-80290 Munich, Germany, Email: jorge.cabello@tum.de |
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Publisher |
Iop Publishing Ltd |
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English |
Summary Language |
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Original Title |
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Edition |
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ISSN |
0031-9155 |
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Expedition |
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Conference |
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Notes |
WOS:000354104700019 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2226 |
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Author |
Llosa, G.; Trovato, M.; Barrio, J.; Etxebeste, A.; Muñoz, E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Solevi, P. |
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Title |
First Images of a Three-layer compton Telescope prototype for Treatment Monitoring in hadron Therapy |
Type |
Journal Article |
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Year |
2016 |
Publication |
Frontiers in Oncology |
Abbreviated Journal |
Front. Oncol. |
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Volume |
6 |
Issue |
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Pages |
14 - 6pp |
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Keywords |
Compton camera; Compton telescope; hadron therapy; treatment monitoring; LaBr3 |
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Abstract |
A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers of LaBr3 crystals coupled to silicon photomulti-plier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary for the prototype operation at low coincidence rates. A spatial resolution of 7.8 mm FWHM has been obtained in the first imaging tests. |
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Address |
[Llosa, Gabriela; Trovato, Marco; Barrio, John; Etxebeste, Ane; Munoz, Enrique; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Solaz, Carles; Solevi, Paola] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
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Frontiers Media Sa |
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English |
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Series Issue |
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Edition |
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ISSN |
2234-943x |
ISBN |
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Conference |
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Notes |
WOS:000369799800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
2785 |
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Author |
Barrio, J.; Etxebeste, A.; Lacasta, C.; Muñoz, E.; Oliver, J.F.; Solaz, C.; Llosa, G. |
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Title |
Performance of VATA64HDR16 ASIC for medical physics applications based on continuous crystals and SiPMs |
Type |
Journal Article |
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Year |
2015 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
10 |
Issue |
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Pages |
P12001 - 12pp |
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Keywords |
Solid state detectors; Photon detectors for UV, visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs etc); Front-end electronics for detector readout; Gamma detectors (scintillators, CZT, HPG, HgI etc) |
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Abstract |
Detectors based on Silicon Photomultipliers (SiPMs) coupled to continuous crystals are being tested in medical physics applications due to their potential high resolution and sensitivity. To cope with the high granularity required for a very good spatial resolution, SiPM matrices with a large amount of elements are needed. To be able to read the information coming from each individual channel, dedicated ASICs are employed. The VATA64HDR16 ASIC is a 64-channel, charge-sensitive amplifier that converts the collected charge into a proportional current or voltage signal. A complete assessment of the suitability of that ASIC for medical physics applications based on continuous crystals and SiPMs has been carried out. The input charge range is linear from 20 pC up to 55 pC. The energy resolution obtained at 511 keV is 10% FWHM with a LaBr3 crystal and 16% FWHM with a LYSO crystal. A coincidence timing resolution of 24 ns FWHM is obtained with two LYSO crystals. |
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Address |
[Barrio, J.; Etxebeste, A.; Lacasta, C.; Munoz, E.; Oliver, J. F.; Solaz, C.; Llosa, G.] Univ Valencia, CSIC, Inst Fis Corpuscular, Parque Cient,C Catedrat Jose Beltran 2, E-46980 Paterna, Spain, Email: John.Barrio@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Conference |
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Notes |
WOS:000369998500034 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
2548 |
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Author |
Etxebeste, A.; Barrio, J.; Muñoz, E.; Oliver, J.F.; Solaz, C.; Llosa, G. |
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Title |
3D position determination in monolithic crystals coupled to SiPMs for PET |
Type |
Journal Article |
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Year |
2016 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
61 |
Issue |
10 |
Pages |
3914-3934 |
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Keywords |
monolithic crystal; silicon photomultiplier; depth of interaction |
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Abstract |
The interest in using continuous monolithic crystals in positron emission tomography (PET) has grown in the last years. Coupled to silicon photomultipliers (SiPMs), the detector can combine high sensitivity and high resolution, the two main factors to be maximized in a positron emission tomograph. In this work, the position determination capability of a detector comprised of a 12 x 12 x 10 mm(3) LYSO crystal coupled to an 8 x 8-pixel array of SiPMs is evaluated. The 3D interaction position of.-rays is estimated using an analytical model of the light distribution including reflections on the facets of the crystal. Monte Carlo simulations have been performed to evaluate different crystal reflectors and geometries. The method has been characterized and applied to different cases. Intrinsic resolution obtained with the position estimation method used in this work, applied to experimental data, achieves sub-millimetre resolution values. Average resolution over the detector surface for 5 mm thick crystal is similar to 0.9 mm FWHM and similar to 1.2 mm FWHM for 10 mm thick crystal. Depth of interaction resolution is close to 2 mm FWHM in both cases, while the FWTM is similar to 5.3 mm for 5 mm thick crystal and similar to 9.6 mm for 10 mm thick crystal. |
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Address |
[Etxebeste, Ane; Barrio, John; Munoz, Enrique; Oliver, Josep F.; Solaz, Carles; Llosa, Gabriela] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: ane.etxebeste@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9155 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000376792800014 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
2708 |
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| Permanent link to this record |
