| Records |
| Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
| Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
| Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
| Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
| Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
| Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Mdpi |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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Notes  |
WOS:001269841000001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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| |
| Author |
Yue, Z. et al; Algora, A.; Nacher, E. |
| Title |
Magnetic moments of thallium isotopes in the vicinity of magic N=126 |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
849 |
Issue |
|
Pages |
138452 - 7pp |
| Keywords |
Laser spectroscopy; Hyperfine structure; Magnetic dipole moments; Theory of finite Fermi systems |
| Abstract |
The magnetic dipole moments (mu) of Tl-209(g)(N =128) and Tl-207(m)(N = 126) have been measured for the first time using the in -source laser resonance -ionization spectroscopy technique with the Laser Ion Source and Trap (LIST) at ISOLDE (CERN). The application of the LIST suppresses the usually overwhelming background of the isobaric francium isotopes and allows access to heavy thallium isotopes with >207. The self -consistent theory of finite Fermi systems based on the energy density functional by Fayans et al. well describes the N dependence of μfor 1/2(+) thallium ground states, as well as μfor the 11/2(-) isomeric states in europium, gold and thallium isotopes. The inclusion of particle-vibration coupling leads to a better agreement between the theory and experiment for mu(Tl-g , I-pi = 1/2(+)). It is shown that beyond mean-field contributions tocannot be neglected at least for thallium isotopes with I-pi = 1/2(+). |
| Address |
[Yue, Z.; Andreyev, A. N.; Cubiss, J. G.] Univ York, Sch Phys Engn & Technol, York YO10 5DD, England, Email: zixuan.yue@cern.ch |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001180137800001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5979 |
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| Author |
Baeza-Ballesteros, J.; Bijnens, J.; Husek, T.; Romero-Lopez, F.; Sharpe, S.R.; Sjo, M. |
| Title |
The three-pion K-matrix at NLO in ChPT |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
03 |
Issue |
3 |
Pages |
048 - 43pp |
| Keywords |
Chiral Lagrangian; Hadronic Spectroscopy; Structure and Interactions; Lattice QCD |
| Abstract |
The three-particle K-matrix, K-df,K-3, is a scheme-dependent quantity that parametrizes short-range three-particle interactions in the relativistic-field-theory three-particle finite-volume formalism. In this work, we compute its value for systems of three pions in all isospin channels through next-to-leading order in Chiral Perturbation Theory, generalizing previous work done at maximum isospin. We obtain analytic expressions through quadratic order (or cubic order, in the case of zero isospin) in the expansion about the three-pion threshold. |
| Address |
[Baeza-Ballesteros, Jorge] Univ Valencia, IFIC, CSIC, Paterna 46980, Spain, Email: jorge.baeza@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001178200000005 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6006 |
| Permanent link to this record |
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| Author |
Pasqualato, G. et al; Gadea, A.; Jurado, M. |
| Title |
An alternative viewpoint on the nuclear structure towards 100Sn: Lifetime measurements in 105Sn |
Type |
Journal Article |
| Year |
2023 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
845 |
Issue |
|
Pages |
138148 - 7pp |
| Keywords |
Nuclear structure; gamma-ray spectroscopy; Transition probabilities; Neutron-deficient isotopes; Odd-mass nuclei; Lifetime measurements |
| Abstract |
This work aims at presenting an alternative approach to the long standing problem of the B(E2) values in Sn isotopes in the vicinity of the N=Z double-magic nucleus Sn-100, until now predominantly measured with relativistic and intermediate-energy Coulomb excitation reactions. The direct measurement of the lifetime of low-lying excited states in odd-even Sn isotopes provides a new and precise guidance for the theoretical description of the nuclear structure in this region. Lifetime measurements have been performed in Sn-105 for the first time with the coincidence Recoil Distance Doppler Shift technique. The lifetime results for the 7/2(1)(+) first excited state and the 11/2(1)(+) state, 2(+)(Sn-104) circle times nu 1g(7/2) multiplet member, are discussed in comparison with state-of-the-art shell model and mean field calculations, highlighting the crucial contribution of proton excitation across the core of Sn-100. The reduced transition probability B(E2) of the 11/2(1)(+) core-coupled state points out an enhanced staggering with respect to the B(E2; 2(1)(+) -> 0(1)(+)) in the even-mass Sn-104 and Sn-106 isotopes. |
| Address |
[Pasqualato, G.; Mengonia, D.; Goasduff, A.; Lenzi, S. M.; Menegazzo, R.; Montaner-Piza, A.; Recchia, F.; Testov, D.] INFN, Sez Padova, Padua, Italy, Email: giorgia.pasqualato@IJCLAB.IN2P3.FR |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001084426400001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5725 |
| Permanent link to this record |
| |
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| |
| Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanderswood, I. |
| Title |
Study of Bc+ meson decays to charmonia plus multihadron final states |
Type |
Journal Article |
| Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
07 |
Issue |
7 |
Pages |
198 - 26pp |
| Keywords |
B Physics; Hadron-Hadron Scattering; QCD; Spectroscopy |
| Abstract |
Four decay modes of the B-c(+) meson into a J/psi meson and multiple charged kaons or pions are studied using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13TeV and corresponding to an integrated luminosity of 9 fb(-1). The decay B-c(+) -> J/psi K+ K- pi(+)pi(+)pi(-) is observed for the first time, and evidence for the B-c(+) -> J/psi 4 pi(+)3 pi(-) decay is found. The decay B-c(+) -> J/psi 3 pi(+)2 pi(-) is observed and the previous observation of the B-c(+) -> psi(2S)pi(+)pi(+)pi(-) decay is confirmed using the psi(2S) -> J/psi pi(+)pi(-) decay mode. Ratios of the branching fractions of these four B-c(+) decay channels are measured. |
| Address |
[Baptista de Souza Leite, J.; Bediaga, I. B.; Cruz Torres, M.; De Freitas Carneiro Da Graca, U.; De Miranda, J. M.; dos Reis, A. C.; Falcao, L. N.; Gomes, A.; Massafferri, A.; Torres Machado, D.] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil, Email: juan.baptista.leite@cern.ch |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
|
Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001071171200001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5817 |
| Permanent link to this record |
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| |
| Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanderswood, I. |
| Title |
Observation of the B0s → χc1(3872)π+π- decay |
Type |
Journal Article |
| Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
07 |
Issue |
7 |
Pages |
084 - 25pp |
| Keywords |
B Physics; Hadron-Hadron Scattering; Quarkonium; Spectroscopy |
| Abstract |
The first observation of the B-s(0) -> (chi(c1)(3872) -> J/Psi pi(broken vertical bar) pi(-)) pi(broken vertical bar) pi(-) decay is reported using proton-proton collision data, corresponding to integrated luminosities of 1, 2 and 6 fb(-1), collected by the LHCb experiment at centre-of-mass energies of 7, 8 and 13TeV, respectively. The ratio of branching fractions relative to the B-s(0) -> (Psi(2S) -> J/Psi pi(+) pi(-)) pi(+) pi(-) decay is measured to be [GRAPHICS] where the first uncertainty is statistical and the second systematic. The mass spectrum of the pi(+) pi(-) system recoiling against the chi(c1)(3872) meson exhibits a large contribution from B-s(0) -> chi(c1)(3872) (integral(0)(980) -> pi(+) pi(-)) decays. |
| Address |
[Leite, J. Baptista de Souza; Bediaga, I. B.; Torres, M. Cruz; Da Graca, U. De Freitas Carneiro; De Miranda, J. M.; dos Reis, A. C.; Falcao, L. N.; Gomes, A.; Massafferri, A.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001063414300001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5744 |
| Permanent link to this record |
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| |
| Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanderswood, I. |
| Title |
Search for the doubly heavy baryon Ξbc+ decaying to J/ψΞc+ |
Type |
Journal Article |
| Year |
2023 |
Publication |
Chinese Physics C |
Abbreviated Journal |
Chin. Phys. C |
| Volume |
47 |
Issue |
9 |
Pages |
093001 - 13pp |
| Keywords |
QCD; B physics; charm physics; spectroscopy |
| Abstract |
A first search for the Xi(+)(bc) -> J/psi Xi c+ decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb(-1) recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of and standard deviations at masses of 6571 and 6694 MeV/c(2), respectively. Upper limits are set on the Xi(+)(bc) baryon production cross-section times the branching fraction relative to that of the B-c(+) -> J/psi Xi(+)(c) decay at centre-of-mass energies of 8 and 13 TeV, in the Xi(+)(bc) and in the rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to, respectively. Upper limits are presented as a function of the Xi(+)(bc) mass and lifetime. |
| Address |
[Baptista De Souza Leite, J.; Bediaga, I. B.; Torres, M. Cruz; De Freitas Carneiro Da Graca, U.; De Miranda, J. M.; dos Reis, A. C.; Falcao, L. N.; Gomes, A.; Massafferri, A.; Torres Machado, D.] Ctr Brasileiro Pesquisas Fisicas CBPF, Rio De Janeiro, Brazil |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
|
| ISSN |
1674-1137 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
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Conference |
|
| Notes |
WOS:001062113700001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5751 |
| Permanent link to this record |
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| Author |
Baeza-Ballesteros, J.; Bijnens, J.; Husek, T.; Romero-Lopez, F.; Sharpe, S.R.; Sjo, M. |
| Title |
The isospin-3 three-particle K-matrix at NLO in ChPT |
Type |
Journal Article |
| Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
05 |
Issue |
5 |
Pages |
187 - 56pp |
| Keywords |
Chiral Lagrangian; Hadronic Spectroscopy; Structure and Interactions; Lattice QCD |
| Abstract |
The three-particle K-matrix, K-df,K-3, is a scheme-dependent quantity that parametrizes short-range three-particle interactions in the relativistic-field-theory three particle finite-volume formalism. In this work, we compute its value for systems of three pions at maximal isospin through next-to-leading order (NLO) in Chiral Perturbation Theory (ChPT). We compare the values to existing lattice QCD results and find that the agreement between lattice QCD data and ChPT in the first two coefficients of the threshold expansion of K-df,K-3 is significantly improved with respect to leading order once NLO effects are incorporated. |
| Address |
[Baeza-Ballesteros, Jorge] Univ Valencia, IFIC, CSIC, Paterna 46980, Spain, Email: jorge.baeza@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000994292300001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5540 |
| Permanent link to this record |
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| Author |
Zago, L. et al; Gadea, A.; Algora, A. |
| Title |
High-spin states in Po-212 above the alpha-decaying (18(+)) isomer |
Type |
Journal Article |
| Year |
2022 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
834 |
Issue |
|
Pages |
137457 - 5pp |
| Keywords |
gamma spectroscopy; Isomer spectroscopy; High-spin spectroscopy |
| Abstract |
The nucleus Po-212 has been produced through the fragmentation of a U-238 primary beam at 1GeV/nucleon at GSI, separated with the FRagment Separator, FRS, and studied via isomer gamma-decay spectroscopy with the RISING setup. Two delayed previously unknown gamma rays have been observed. One has been attributed to the E3 decay of a 21(-) isomeric state feeding the alpha-emitting 45-s (18(+)) high-spin isomer. The other gamma-ray line has been assigned to the decay of a higher-lying 23(+) metastable state. These are the first observations of high-spin states above the Po-212 (18(+)) isomer, by virtue of the selectivity obtained via ion-by-ion identification of U-238 fragmentation products. Comparison with shell-model calculations points to shortfalls in the nuclear interactions involving high- jproton and neutron orbitals, to which the region around Z similar to 100 is sensitive. |
| Address |
[Zago, L.; Lunardi, S.; Lenzi, S. M.; Mengoni, D.] Univ Padua, Dipartimento Fis, I-35131 Padua, Italy, Email: luca.zago@lnl.infn.it |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000890050000015 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5457 |
| Permanent link to this record |
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| Author |
Albaladejo, M.; Bibrzycki, L.; Dawid, S.M.; Fernandez-Ramirez, C.; Gonzalez-Solis, S.; Hiller Blin, A.N.; Jackura, A.W.; Mathieu, V.; Mikhasenko, M.; Make, V.I.; Passemar, E.; Pilloni, A.; Rodas, A.; Silva-Castro, J.A.; Smith, W.A.; Szczepaniak, A.P.; Winney, D. |
| Title |
Novel approaches in hadron spectroscopy |
Type |
Journal Article |
| Year |
2022 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
| Volume |
127 |
Issue |
|
Pages |
103981 - 75pp |
| Keywords |
Hadron spectroscopy; Exotic hadrons; Three-body scattering; Resonance production |
| Abstract |
The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy. |
| Address |
[Albaladejo, Miguel; Blin, Astrid N. Hiller; Jackura, Andrew W.; Mokeev, Victor, I; Passemar, Emilie; Rodas, Arkaitz; Szczepaniak, Adam P.] Thomas Jefferson Natl Accelerator Facil, Theory Ctr & Phys Div, Newport News, VA 23606 USA, Email: alessandro.pilloni@unime.it |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0146-6410 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000883770300003 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5422 |
| Permanent link to this record |
