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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Figueroa, D. G., Florio, A., Torrenti, F., & Valkenburg, W. (2021). The art of simulating the early universe. Part I. Integration techniques and canonical cases. J. Cosmol. Astropart. Phys., 04(4), 035–108pp.
Abstract: We present a comprehensive discussion on lattice techniques for the simulation of scalar and gauge field dynamics in an expanding universe. After reviewing the continuum formulation of scalar and gauge field interactions in Minkowski and FLRW backgrounds, we introduce the basic tools for the discretization of field theories, including lattice gauge invariant techniques. Following, we discuss and classify numerical algorithms, ranging from methods of O(delta t(2)) accuracy like staggered leapfrog and Verlet integration, to Runge-Kutta methods up to O(delta t(4)) accuracy, and the Yoshida and Gauss-Legendre higher-order integrators, accurate up to O(delta t(10)) We adapt these methods for their use in classical lattice simulations of the non-linear dynamics of scalar and gauge fields in an expanding grid in 3+1 dimensions, including the case of 'self-consistent' expansion sourced by the volume average of the fields' energy and pressure densities. We present lattice formulations of canonical cases of: i) Interacting scalar fields, ii) Abelian U(1) gauge theories, and iii) Non-Abelian SU(2) gauge theories. In all three cases we provide symplectic integrators, with accuracy ranging from O(delta t(2)) up to O(delta t(10)) For each algorithm we provide the form of relevant observables, such as energy density components, field spectra and the Hubble constraint. We note that all our algorithms for gauge theories always respect the Gauss constraint to machine precision, including when 'self-consistent' expansion is considered. As a numerical example we analyze the post-inflationary dynamics of an oscillating inflaton charged under SU(2) x U(1). We note that the present manuscript is meant to be part of the theoretical basis for the code CosmoLattice, a multi-purpose MPI-based package for simulating the non-linear evolution of field theories in an expanding universe, publicly available at http://www.cosrnolattice.net.
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n_TOF Collaboration(Gawlik, A. et al), Domingo-Pardo, C., Tain, J. L., & Tarifeño-Saldivia, A. (2021). Radiative Neutron Capture Cross-Section Measurement of Ge Isotopes at n_TOF CERN Facility and Its Importance for Stellar Nucleosynthesis. Acta Phys. Pol. A, 139(4), 383–388.
Abstract: This manuscript summarizes the results of radiative neutron capture cross-section measurements on two stable germanium isotopes, Ge-70 and Ge-73. Experiments were performed at the n_TOF facility at CERN via the time-of-flight technique, over a wide neutron energy range, for all stable germanium isotopes (70,72,73,74, and 76). Results for Ge-70 [Phys. Rev. C 100, 045804 (2019)] and Ge-73 [Phys. Lett. B 790, 458 (2019)] are already published. In the field of nuclear structure, such measurements allow to study excited levels close to the neutron binding energy and to obtain information on nuclear properties. In stellar nucleosynthesis research, neutron induced reactions on germanium are of importance for nucleosynthesis in the weak component of the slow neutron capture processes.
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Aguilera-Verdugo, J. J., Hernandez-Pinto, R. J., Rodrigo, G., Sborlini, G. F. R., & Torres Bobadilla, W. J. (2021). Mathematical properties of nested residues and their application to multi-loop scattering amplitudes. J. High Energy Phys., 02(2), 112–42pp.
Abstract: The computation of multi-loop multi-leg scattering amplitudes plays a key role to improve the precision of theoretical predictions for particle physics at high-energy colliders. In this work, we focus on the mathematical properties of the novel integrand-level representation of Feynman integrals, which is based on the Loop-Tree Duality (LTD). We explore the behaviour of the multi-loop iterated residues and explicitly show, by developing a general compact and elegant proof, that contributions associated to displaced poles are cancelled out. The remaining residues, called nested residues as originally introduced in ref. [1], encode the relevant physical information and are naturally mapped onto physical configurations associated to nondisjoint on-shell states. By going further on the mathematical structure of the nested residues, we prove that unphysical singularities vanish, and show how the final expressions can be written by using only causal denominators. In this way, we provide a mathematical proof for the all-loop formulae presented in ref. [2].
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ANTARES Collaboration(Albert, A. et al), Alves, S., Carretero, V., Colomer, M., Gozzini, R., Hernandez-Rey, J. J., et al. (2021). Measurement of the atmospheric nu(e) and nu(mu) energy spectra with the ANTARES neutrino telescope. Phys. Lett. B, 816, 136228–7pp.
Abstract: This letter presents a combined measurement of the energy spectra of atmospheric nu(e) and nu(mu) in the energy range between similar to 100 GeV and similar to 50 TeV with the ANTARES neutrino telescope. The analysis uses 3012 days of detector livetime in the period 2007-2017, and selects 1016 neutrinos interacting in (or close to) the instrumented volume of the detector, yielding shower-like events (mainly from nu(e) + (nu) over bar (e) charged current plus all neutrino neutral current interactions) and starting track events (mainly from nu(mu) + (nu) over bar (mu) charged current interactions). The contamination by atmospheric muons in the final sample is suppressed at the level of a few per mill by different steps in the selection analysis, including a Boosted Decision Tree classifier. The distribution of reconstructed events is unfolded in terms of electron and muon neutrino fluxes. The derived energy spectra are compared with previous measurements that, above 100 GeV, are limited to experiments in polar ice and, for nu(mu), to Super-Kamiokande.
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