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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords  |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Publisher |
Mdpi |
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English |
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Notes |
WOS:001269841000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Bruschini, R.; Gonzalez, P. |
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Title |
chi(c1)(2p): an overshadowed charmoniumlike resonance |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
216 - 23pp |
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Keywords |
Properties of Hadrons; Quarkonium |
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Abstract |
A thorough study of the J(PC )= 1(++) elastic D0 & macr;D*(0) and D+D*(-) scattering, where the form of the meson-meson interaction is inferred from lattice QCD calculations of string breaking, is carried out for center-of-mass energies up to 4 GeV. We show that the presence of chi c1(3872), which can be naturally assigned to either a bound or virtual charmoniumlike state close below the D0 & macr;D*0 threshold, can overshadow a quasiconventional charmoniumlike resonance lying above threshold. This makes difficult the experimental detection of this resonance through the D0 & macr;D*(0) and D+D*(-) channels, despite being its expected main decay modes. We analyze alternative strong and electromagnetic decay modes. Comparison with existing data shows that this resonance may have already been observed through its decay to omega J/psi. |
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[Bruschini, R.] Ohio State Univ, Dept Phys, 191 West Woodruff Ave, Columbus, OH 43210 USA, Email: bruschini.1@osu.edu; |
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Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:000938122900008 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5490 |
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Author |
Consiglio, R.; de Salas, P.F.; Mangano, G.; Miele, G.; Pastor, S.; Pisanti, O. |
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Title |
PArthENoPE reloaded |
Type |
Journal Article |
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Year |
2018 |
Publication |
Computer Physics Communications |
Abbreviated Journal |
Comput. Phys. Commun. |
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Volume |
233 |
Issue |
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Pages |
237-242 |
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Keywords |
Primordial nucleosynthesis; Cosmology; Neutrino physics |
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Abstract |
We describe the main features of a new and updated version of the program PArthENoPE, which computes the abundances of light elements produced during Big Bang Nucleosynthesis. As the previous first release in 2008, the new one, PArthENoPE2.0, is publicly available and distributed from the code site, http://parthenope.na.infn.it . Apart from minor changes, which will be also detailed, the main improvements are as follows. The powerful, but not freely accessible, NAG routines have been substituted by ODEPACK libraries, without any significant loss in precision. Moreover, we have developed a Graphical User Interface (GUI) which allows a friendly use of the code and a simpler implementation of running for grids of input parameters. New Version program summary Program Title: PArthENoPE2.0 Program Files doi : http://dx.doi.org/10.17632/wvgr7d8yt9.1 Licensing provisions: GPLv3 Programming language: Fortran 77 and Python Supplementary material: User Manual available on the web page http://parthenope.na.infn.it Journal reference of previous version: Comput. Phys. Commun. 178 (2008) 956 971 Does the new version supersede the previous version?: Yes Reasons for the new version: Make the code more versatile and user friendly Summary of revisions: (1) Publicly available libraries (2) GUI for configuration Nature of problem: Computation of yields of light elements synthesized in the primordial universe Solution method: Livermore Solver for Ordinary Differential Equations (LSODE) for stiff and nonstiff systems |
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Address |
[Consiglio, R.; Miele, G.; Pisanti, O.] Univ Napoli Federico II, Dipartimento Fis E Pancini, Via Cintia, I-80126 Naples, Italy, Email: pisanti@na.infn.it |
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Publisher |
Elsevier Science Bv |
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English |
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ISSN |
0010-4655 |
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Notes |
WOS:000444667100020 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3729 |
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Author |
Gariazzo, S.; de Salas, P.F.; Pisanti, O.; Consiglio, R. |
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Title |
PArthENoPE revolutions |
Type |
Journal Article |
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Year |
2022 |
Publication |
Computer Physics Communications |
Abbreviated Journal |
Comput. Phys. Commun. |
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Volume |
271 |
Issue |
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Pages |
108205 - 13pp |
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Keywords |
Primordial nucleosynthesis; Cosmology; Neutrino physics |
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Abstract |
This paper presents the main features of a new and updated version of the program PArthENoPE, which the community has been using for many years for computing the abundances of light elements produced during Big Bang Nucleosynthesis. This is the third release of the PArthENoPE code, after the 2008 and the 2018 ones, and will be distributed from the code's website, http://parthenope.na.infn.it. Apart from minor changes, the main improvements in this new version include a revisited implementation of the nuclear rates for the most important reactions of deuterium destruction, H-2(p,gamma) He-3, H-2(d, n)He-3 and H-2(d, p)H-3, and a re-designed GUI, which extends the functionality of the previous one. The new GUI, in particular, supersedes the previous tools for running over grids of parameters with a better management of parallel runs, and it offers a brand-new set of functions for plotting the results. Program summary Program title: PArthENoPE 3.0 CPC Library link to program files: https://doi.org/10.17632/wygr7d8yt9.2 Developer's repository link: http://parthenope.na.infn.it Licensing provisions: GPLv3 Programming language: Fortran 77 and Python Nature of problem: Computation of yields of light elements synthesized in the primordial universe Solution method: Livermore Solver for Ordinary Differential Equations (LSODE) for stiff and nonstiff systems, Python GUI for running and plotting Journal reference of previous version: Comput. Phys. Commun. 233 (2018) 237-242 Does the new version supersede the previous version?: Yes Reasons for the new version: Update of the physics and improvements in the GUI Summary of revisions: Update of the physics implemented in the Fortran code and improvements in the GUI functionalities, in particular new plotting functions. |
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Address |
[Gariazzo, S.] INFN, Sez Torino, Via P Giuria 1, I-10125 Turin, Italy, Email: pisanti@na.infn.it |
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Elsevier |
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English |
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0010-4655 |
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Notes |
WOS:000720461800020 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5027 |
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Author |
Villanueva-Domingo, P.; Mena, O.; Palomares-Ruiz, S. |
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Title |
A Brief Review on Primordial Black Holes as Dark Matter |
Type |
Journal Article |
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Year |
2021 |
Publication |
Frontiers in Astronomy and Space Sciences |
Abbreviated Journal |
Front. Astron. Space Sci. |
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Volume |
8 |
Issue |
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Pages |
681084 - 10pp |
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Keywords |
primordial black holes; dark matter; cosmology; accretion; 21 cm cosmology; gravitational waves; cosmic microwave background; microlensing |
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Abstract |
Primordial black holes (PBHs) represent a natural candidate for one of the components of the dark matter (DM) in the Universe. In this review, we shall discuss the basics of their formation, abundance and signatures. Some of their characteristic signals are examined, such as the emission of particles due to Hawking evaporation and the accretion of the surrounding matter, effects which could leave an impact in the evolution of the Universe and the formation of structures. The most relevant probes capable of constraining their masses and population are discussed. |
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Address |
[Villanueva-Domingo, Pablo; Mena, Olga; Palomares-Ruiz, Sergio] CSIC Univ Valencia, Inst Fis Corpuscular IFIC, Paterna, Spain, Email: pablo.villanueva.domingo@gmail.com |
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Publisher |
Frontiers Media Sa |
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English |
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ISSN |
2296-987x |
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Notes |
WOS:000660081700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4852 |
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