Abstract: Simple Summary There are no brachytherapy treatment planning systems (TPS) exclusively for the treatment of cervical tumours, so general-purpose TPSs are used. However, these treatments have some particular features concerning the treatment of other pathologies, especially in the case of exclusive use of MRI as an imaging modality and the presence of gynaecological applicators in combination with an interstitial part. That is why it is essential to review the latest versions of commercial TPSs to find the potential features to improve with the help of a group of experimented medical physicists and radiation oncologists. Furthermore, after reviewing the recent literature for advances applicable to cervical brachytherapy and through his own clinical experience, possible improvements are proposed to software providers for the development of new tools. Intracavitary brachytherapy (BT, Interventional Radiotherapy, IRT), plays an essential role in the curative intent of locally advanced cervical cancer, for which the conventional approach involves external beam radiotherapy with concurrent chemotherapy followed by BT. This work aims to review the different methodologies used by commercially available treatment planning systems (TPSs) in exclusive magnetic resonance imaging-based (MRI) cervix BT with interstitial component treatments. Practical aspects and improvements to be implemented into the TPSs are discussed. This review is based on the clinical expertise of a group of radiation oncologists and medical physicists and on interactive demos provided by the software manufacturers. The TPS versions considered include all the new tools currently in development for future commercial releases. The specialists from the supplier companies were asked to propose solutions to some of the challenges often encountered in a clinical environment through a questionnaire. The results include not only such answers but also comments by the authors that, in their opinion, could help solve the challenges covered in these questions. This study summarizes the possibilities offered nowadays by commercial TPSs, highlighting the absence of some useful tools that would notably improve the planning of MR-based interstitial component cervix brachytherapy.

Abstract: We study the d(2)Gamma(d)/(d omega d cos theta(d) ), d Gamma(d)/d cos theta(d) and d Gamma(d)/dE(d) distributions, which are defined in terms of the visible energy and polar angle of the charged particle from the tau-decay in b -> C tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau), reactions. These differential decay widths could be measured in the near future with certain precision. The first two contain information on the transverse tau-spin, tau-angular and tau-angular-spin asymmetries of the H-b -> H-c tau(nu) over bar (tau) parent decay and, from a dynamical point of view, they are richer than the commonly used one, d(2)Gamma(d)/(d omega dE(d)), since the latter only depends on the tau longitudinal polarization. We pay attention to the deviations with respect to the predictions of the standard model (SM) for these new observables, considering new physics (NP) operators constructed using both right- and left-handed neutrino fields, within an effective field-theory approach. We present results for Lambda(b) -> Lambda(c)tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau) and (B) over bar -> D-(*()) tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau) sequential decays and discuss their use to disentangle between different NP models. In this respect, we show that d Gamma(d)/d cos theta(d) , which should be measured with sufficiently good statistics, becomes quite useful, especially in the tau -> pi nu(tau) mode. The study carried out in this work could be of special relevance due to the recent LHCb measurement of the lepton flavor universality ratio R Lambda(c) in agreement with the SM. The experiment identified the tau using its hadron decay into pi(-)pi(+)pi(-)nu(tau), and this result for R Lambda(c )which is in conflict with the phenomenology from the b-meson sector, needs confirmation from other tau reconstruction channels.

Abstract: The measured branching fractions of B-mesons into leptonic final states derived by the LHCb, Belle and BaBar collaborations hint towards the breakdown of lepton flavour universality. In this work we take at face value the so-called R-D(()*()) observables that are defined as the ratios of neutral B-meson charged-current decays into a D-(*())-meson, a charged lepton and a neutrino final state in the tau and light lepton channels. A well-studied and simple solution to this charged current anomaly is to introduce a scalar leptoquark S-1 that couples to the second and third generation of fermions. We investigate how S-1 can also serve as a mediator between the Standard Model and a dark sector. We study this scenario in detail and estimate the constraints arising from collider searches for leptoquarks, collider searches for missing energy signals, direct detection experiments and the dark matter relic abundance. We stress that the production of a pair of leptoquarks that decays into different final states (i.e. the commonly called “mixed” channels) provides critical information for identifying the underlying dynamics, and we exemplify this by studying the t tau b nu and the resonant S-1 plus missing energy channels. We find that direct detection data provides non-negligible constraints on the leptoquark coupling to the dark sector, which in turn affects the relic abundance. We also show that the correct relic abundance can not only arise via standard freeze-out, but also through conversion-driven freeze-out. We illustrate the rich phenomenology of the model with a few selected benchmark points, providing a broad stroke of the interesting connection between lepton flavour universality violation and dark matter.