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ATLAS Collaboration(Aad, G. et al), Alvarez Piqueras, D., Cabrera Urban, S., Castillo Gimenez, V., Costa, M. J., Fernandez Martinez, P., et al. (2015). Measurement of four-jet differential cross sections in root s=8 TeV proton-proton collisions using the ATLAS detector. J. High Energy Phys., 12(12), 105–76pp.
Abstract: Differential cross sections for the production of at least four jets have been measured in proton-proton collisions at root s = 8 TeV at the Large Hadron Collider using the ATLAS detector. Events are selected if the four anti-k(t) R = 0.4 jets with the largest transverse momentum (p(T)) within the rapidity range vertical bar y vertical bar < 2 : 8 are well separated (Delta R-4j(min) > 0.65), all have p(T) > 64 GeV, and include at least one jet with p(T) > 100 GeV. The dataset corresponds to an integrated luminosity of 20.3 fb(-1). The cross sections, corrected for detector effects, are compared to leading-order and next-to-leading-order calculations as a function of the jet momenta, invariant masses, minimum and maximum opening angles and other kinematic variables.
Keywords: Jet physics; Hadron-Hadron scattering; QCD
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Ballester, F., Tedgren, A. C., Granero, D., Haworth, A., Mourtada, F., Fonseca, G. P., et al. (2015). A generic high-dose rate Ir-192 brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism. Med. Phys., 42(6), 3048–3062.
Abstract: Purpose: In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) Ir-192 source and a virtual water phantom were designed, which can be imported into a TPS. Methods: A hypothetical, generic HDR Ir-192 source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic Ir-192 source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra (R) Brachy with advanced collapsed-cone engine (ACE) and BrachyVision AcuRos (TM)]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and pENELopE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201)(3) voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR Ir-192 source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by different investigators. MC results were then compared against dose calculated using TG-43 and MBDCA methods. Results: TG-43 and PSS datasets were generated for the generic source, the PSS data for use with the ACE algorithm. The dose-rate constant values obtained from seven MC simulations, performed independently using different codes, were in excellent agreement, yielding an average of 1.1109 +/- 0.0004 cGy/(h U) (k = 1, Type A uncertainty). MC calculated dose-rate distributions for the two plans were also found to be in excellent agreement, with differences within type A uncertainties. Differences between commercial MBDCA and MC results were test, position, and calculation parameter dependent. On average, however, these differences were within 1% for ACUROS and 2% for ACE at clinically relevant distances. Conclusions: A hypothetical, generic HDR Ir-192 source was designed and implemented in two commercially available TPSs employing different MBDCAs. Reference dose distributions for this source were benchmarked and used for the evaluation of MBDCA calculations employing a virtual, cubic water phantom in the form of a CT DICOM image series. The implementation of a generic source of identical design in all TPSs using MBDCAs is an important step toward supporting univocal commissioning procedures and direct comparisons between TPSs.
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Solevi, P., Magrin, G., Moro, D., & Mayer, R. (2015). Monte Carlo study of microdosimetric diamond detectors. Phys. Med. Biol., 60(18), 7069–7083.
Abstract: Ion-beam therapy provides a high dose conformity and increased radiobiological effectiveness with respect to conventional radiation-therapy. Strict constraints on the maximum uncertainty on the biological weighted dose and consequently on the biological weighting factor require the determination of the radiation quality, defined as the types and energy spectra of the radiation at a specific point. However the experimental determination of radiation quality, in particular for an internal target, is not simple and the features of ion interactions and treatment delivery require dedicated and optimized detectors. Recently chemical vapor deposition (CVD) diamond detectors have been suggested as ion-beam therapy microdosimeters. Diamond detectors can be manufactured with small cross sections and thin shapes, ideal to cope with the high fluence rate. However the sensitive volume of solid state detectors significantly deviates from conventional microdosimeters, with a diameter that can be up to 1000 times the height. This difference requires a redefinition of the concept of sensitive thickness and a deep study of the secondary to primary radiation, of the wall effects and of the impact of the orientation of the detector with respect to the radiation field. The present work intends to study through Monte Carlo simulations the impact of the detector geometry on the determination of radiation quality quantities, in particular on the relative contribution of primary and secondary radiation. The dependence of microdosimetric quantities such as the unrestricted linear energy L and the lineal energy y are investigated for different detector cross sections, by varying the particle type (carbon ions and protons) and its energy.
Keywords: ion-beam therapy; microdosimetry; diamonds; GATE
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Pallis, C., & Shafi, Q. (2015). Gravity waves from non-minimal quadratic inflation. J. Cosmol. Astropart. Phys., 03(3), 023–31pp.
Abstract: We discuss non-minimal quadratic inflation in supersymmetric (SUSY) and non-SUSY models which entails a linear coupling of the inflaton to gravity. Imposing a lower bound on the parameter c(R), involved in the coupling between the inflaton and the Ricci scalar curvature, inflation can be attained even for subplanckian values of the inflaton while the corresponding effective theory respects the perturbative unitarity up to the Planck scale. Working in the non-SUSY context we also consider radiative corrections to the inflationary potential due to a possible coupling of the inflaton to bosons or fermions. We find ranges of the parameters, depending mildly on the renormalization scale, with adjustable values of the spectral index n(s), tensor-to-scalar ratio r similar or equal to (2 – 4) . 10(-3), and an inflaton mass close to 3 . 10 (13) GeV. In the SUSY framework we employ two gauge singlet chiral superfields, a logarithmic Kahler potential including all the allowed terms up to fourth order in powers of the various fields, and determine uniquely the superpotential by applying a continuous R and a global U(1) symmetry. When the Kahler manifold exhibits a no-scale-type symmetry, the model predicts n(s) similar or equal to 0.963 and r similar or equal to 0.004. Beyond no-scale SUGRA, n(s) and r depend crucially on the coefficient involved in the fourth order term, which mixes the inflaton with the accompanying non-inflaton field in the Kahler potential, and the prefactor encountered in it. Increasing slightly the latter above (-3), an efficient enhancement of the resulting r can be achieved putting it in the observable range. The inflaton mass in the last case is confined in the range (5 – 9) . 10(13) GeV.
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Palomo, R., Pujades, M. C., Gimeno-Olmos, J., Carmona, V., Lliso, F., Candela-Juan, C., et al. (2015). Evaluation of lens absorbed dose with Cone Beam IGRT procedures. J. Radiol. Prot., 35(4), N33–N41.
Abstract: The purpose of this work is to evaluate the absorbed dose to the eye lenses due to the cone beam computed tomography (CBCT) system used to accurately position the patient during head-and-neck image guided procedures. The on-board imaging (OBI) systems (v. 1.5) of Clinac iX and TrueBeam (Varian) accelerators were used to evaluate the imparted dose to the eye lenses and some additional points of the head. All CBCT scans were acquired with the Standard-Dose Head protocol from Varian. Doses were measured using thermoluminescence dosimeters (TLDs) placed in an anthropomorphic phantom. TLDs were calibrated at the beam quality used to reduce their energy dependence. Average dose to the lens due to the OBI systems of the Clinac iX and the TrueBeam were 0.71 +/- 0.07 mGy/CBCT and 0.70 +/- 0.08 mGy/CBCT, respectively. The extra absorbed dose received by the eye lenses due to one CBCT acquisition with the studied protocol is far below the 500 mGy threshold established by ICRP for cataract formation (ICRP 2011 Statement on Tissue Reactions). However, the incremental effect of several CBCT acquisitions during the whole treatment should be taken into account.
Keywords: IGRT; CBCT; lens absorbed dose; TLD
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