Abstract: Proton therapy is a cancer treatment technique currently in growth since it offers advantages with respect to conventional X-ray and gamma-ray radiotherapy. In particular, better control of the dose deposition allowing to reach higher conformity in the treatments causing less secondary effects. However, in order to take full advantage of its potential, improvements in treatment planning and dose verification are required. A new prototype of proton computed tomography scanner is proposed to design more accurate and precise treatment plans for proton therapy. Our prototype is formed by double-sided silicon strip detectors and scintillators of LaBr3(Ce) with high energy resolution and fast response. Here, the results obtained from an experiment performed using a 100-MeV proton beam are presented. Proton radiographs of polymethyl methacrylate (PMMA) samples of 50-mm thickness with spatial patterns in aluminum were taken. Their properties were studied, including reproduction of the dimensions, spatial resolution, and sensitivity to different materials. Structures of up to 2 mm are well resolved and the sensitivity of the system was enough to distinguish the thicknesses of 10 mm of aluminum or PMMA. The spatial resolution of the images was 0.3 line pairs per mm (MTF-10%). This constitutes the first step to validate the device as a proton radiography scanner.

Abstract: In 1988 the NA31 experiment presented the first evidence of direct CP violation in the K-0 -> pi pi decay amplitudes. A clear signal with a 7.2 sigma statistical significance was later established with the full data samples from the NA31, E731, NA48 and KTeV experiments, confirming that CP violation is associated with a Delta S = 1 quark transition, as predicted by the Standard Model. However, the theoretical prediction for the measured ratio epsilon'/epsilon has been a subject of strong controversy along the years. Although the underlying physics was already clarified in 2001, the recent release of improved lattice data has revived again the theoretical debate. We review the current status, discussing in detail the different ingredients that enter into the calculation of this observable and the reasons why seemingly contradictory predictions were obtained in the past by several groups. An update of the Standard Model prediction is presented and the prospects for future improvements are analysed. Taking into account all known short-distance and long-distance contributions, one obtains Re (epsilon' / epsilon) = (15 +/- 7) . 10(-4), in good agreement with the experimental measurement.

Abstract: This paper presents a search for new heavy particles decaying into a pair of top quarks using 139 fb(-1) of proton-proton collision data recorded at a centre-of-mass energy of root s = 13TeV with the ATLAS detector at the Large Hadron Collider. The search is performed using events consistent with pair production of high-transverse-momentum top quarks and their subsequent decays into the fully hadronic final states. The analysis is optimized for resonances decaying into a t (t) over bar pair with mass above 1.4TeV, exploiting a dedicated multivariate technique with jet substructure to identify hadronically decaying top quarks using large-radius jets and evaluating the background expectation from data. No significant deviation from the background prediction is observed. Limits are set on the production cross-section times branching fraction for the new Z' boson in a topcolor-assisted-technicolor model. The Z0 boson masses below 3.9 and 4.7TeV are excluded at 95% confidence level for the decay widths of 1% and 3%, respectively.

Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.

Abstract: Light sources that emit repetitive subnanosecond pulses are used in neutrino telescopes for time calibration. Optical pulses with an ultra-narrow (subnanosecond) width can replicate the light produced by neutrino interactions, and are an important calibration and test element. By measuring the time-of-flight of the light, it is possible to provide a relative time calibration for all the detector photomultipliers. This work presents the ultra-narrow time optical pulse emitter based on a laser (UNTOPEL), an instrument emitting ultra-short laser optical pulses with a duration of 500 ps, energies per pulse of four microjoules at a wavelength of 532 nm, and a timing precision of 400 ps. The UNTOPEL pulse intensity can be fine-tuned, which is a novelty and a significant advantage in those applications that need to illuminate light detectors located at different distances with the same light intensity. The UNTOPEL pulse intensity can be controlled remotely, allowing for its use in operating conditions where physical access is impossible or difficult. Moreover, it is easy to operate and can be easily controlled through an inter-integrated circuit bus. The UNTOPEL is a sound instrument used when subnanosecond pulses and variable energy emissions are needed.