Abstract: A search for the decays of the B-c(+) meson to p (p) over bar pi(+) is performed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV. No signal is found and an upper limit, at 95% confidence level, is set, f(c)/f(u) x B(B-c(+) -> p (p) over bar pi(+)) < 3.6 x 10(-8) in the kinematic region m(p<(p)over bar>) < 2.85 GeV/c(2), p(T)(B) < 20 GeV/c and 2.0 < y(B) < 4.5, where B is the branching fraction and f(c)(f(u)) is the fragmentation fraction of the b quark into a B-c+(B+) meson.