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Author |
Carrasco-Ribelles, L.A.; Pardo-Mas, J.R.; Tortajada, S.; Saez, C.; Valdivieso, B.; Garcia-Gomez, J.M. |
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Title |
Predicting morbidity by local similarities in multi-scale patient trajectories |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of Biomedical Informatics |
Abbreviated Journal |
J. Biomed. Inform. |
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Volume |
120 |
Issue  |
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Pages |
103837 - 9pp |
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Keywords |
Patient trajectory; Risk prediction; Local alignment; Dynamic programming; Diabetes; Cardiovascular disease |
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Abstract |
Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening. |
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Address |
[Carrasco-Ribelles, Lucia A.; Pardo-Mas, Jose Ramon; Saez, Carlos; Garcia-Gomez, Juan M.] Univ Politecn Valencia, Biomed Data Sci Lab BDSLAB, Inst Tecnol Informat & Comunicac ITACA, Camino Vera S-N, Valencia 46022, Spain, Email: lucarri@etsii.upv.es; |
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Academic Press Inc Elsevier Science |
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English |
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ISSN |
1532-0464 |
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Notes |
WOS:000683527500003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4934 |
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Author |
Wieduwilt, P.; Paschen, B.; Schreeck, H.; Schwenker, B.; Soltau, J.; Ahlburg, P.; Dingfelder, J.; Frey, A.; Gomis, P.; Lutticke, F.; Marinas, C. |
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Title |
Performance of production modules of the Belle II pixel detector in a high-energy particle beam |
Type |
Journal Article |
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Year |
2021 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
991 |
Issue |
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Pages |
164978 - 15pp |
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Keywords |
DEPFET; DESY testbeam; Pixel detector; Belle II; Vertex detector |
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Abstract |
The Belle II experiment at the Super B factory SuperKEKB, an asymmetric e(+) e(-) collider located in Tsukuba, Japan, is tailored to perform precision B physics measurements. The centre of mass energy of the collisions is equal to the rest mass of the gamma (4S) resonance of m(gamma(4S)) = 10.58 GeV. A high vertex resolution is essential for measuring the decay vertices of B mesons. Typical momenta of the decay products are ranging from a few tens of MeV to a few GeV and multiple scattering has a significant impact on the vertex resolution. The VerteX Detector (VXD) for Belle II is therefore designed to have as little material as possible inside the acceptance region. Especially the innermost two layers, populated by the PiXel Detector (PXD), have to be ultra-thin. The PXD is based on DEpleted P-channel Field Effect Transistors (DEPFETs) with a thickness of only 75 μm. Spatial resolution and hit efficiency of production detector modules were studied in beam tests performed at the DESY test beam facility. The spatial resolution was investigated as a function of the incidence angle and improvements due to charge sharing are demonstrated. The measured module performance is compatible with the requirements for Belle II. |
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Address |
[Paschen, B.; Ahlburg, P.; Dingfelder, J.; Luetticke, F.] Univ Bonn, Phys Inst, Nussallee 12, D-53115 Bonn, Germany, Email: philipp.wieduwilt@phys.uni-goettingen.de; |
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Elsevier |
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English |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000686054900010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4941 |
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Author |
Vijande, J.; Tedgren, A.C.; Ballester, F.; Baltas, D.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; De Werd, L.; Perez-Calatayud, J. |
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Title |
Source strength determination in iridium-192 and cobalt-60 brachytherapy: A European survey on the level of agreement between clinical measurements and manufacturer certificates |
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Journal Article |
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Year |
2021 |
Publication |
Physics and Imaging in Radiation Oncology |
Abbreviated Journal |
Phys. Imag. Radiat. Oncol. |
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Volume |
19 |
Issue |
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Pages |
108-111 |
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Keywords |
RAKR; Calibration; HDR; PDR; Brachytherapy |
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Abstract |
Background and purpose: Brachytherapy treatment outcomes depend on the accuracy of the delivered dose distribution, which is proportional to the reference air-kerma rate (RAKR). Current societal recommendations require the medical physicist to compare the measured RAKR values to the manufacturer source calibration certificate. The purpose of this work was to report agreement observed in current clinical practice in the European Union. Materials and methods: A European survey was performed for high- and pulsed-dose-rate (HDR and PDR) highenergy sources (Ir-192 and Co-60), to quantify observed RAKR differences. Medical physicists at eighteen hospitals from eight European countries were contacted, providing 1,032 data points from 2001 to 2020. Results: Over the survey period, 77% of the Ir-192 measurements used a well chamber instead of the older Krieger phantom method. Mean differences with the manufacturer calibration certificate were 0.01% +/- 1.15% for Ir-192 and -0.1% +/- 1.3% for Co-60. Over 95% of RAKR measurements in the clinic were within 3% of the manufacturer calibration certificate. Conclusions: This study showed that the agreement level was generally better than that reflected in prior societal recommendations positing 5%. Future recommendations on high-energy HDR and PDR source calibrations in the clinic may consider tightened agreements levels. |
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Address |
[Vijande, Javier; Ballester, Facundo] Univ Valencia UV, Dept Fis Atom Mol & Nucl, Burjassot, Spain, Email: Javier.vijande@uv.es |
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Elsevier |
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English |
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Notes |
WOS:000694711800017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4969 |
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Author |
Jay, G.; Arnault, P.; Debbasch, F. |
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Title |
Dirac quantum walks with conserved angular momentum |
Type |
Journal Article |
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Year |
2021 |
Publication |
Quantum Studies-Mathematics and Foundations |
Abbreviated Journal |
Quantum Stud. Math. Found. |
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Volume |
8 |
Issue |
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Pages |
419-430 |
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Keywords |
Quantum walks; Quantum simulation; Lattice field theory |
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Abstract |
A quantum walk (QW) simulating the flat (1+2)D Dirac equation on a spatial polar grid is constructed. Because fermions are represented by spinors, which do not constitute a representation of the rotation group SO(3), but rather of its double cover SU(2), the QW can only be defined globally on an extended spacetime where the polar angle extends from 0 to 4 pi. The coupling of the QW with arbitrary electromagnetic fields is also presented. Finally, the cylindrical relativistic Landau levels of the Dirac equation are computed explicitly and simulated by the QW. |
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Address |
[Jay, Gareth] Univ Western Australia, Phys Dept, Perth, WA 6009, Australia, Email: gareth.jay@uwa.edu.au; |
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Publisher |
Springer |
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English |
Summary Language |
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ISSN |
2196-5609 |
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Conference |
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Notes |
WOS:000697709700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4975 |
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Author |
Barrientos, L.; Borja-Lloret, M.; Etxebeste, A.; Muñoz, E.; Oliver, J.F.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G. |
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Title |
Performance evaluation of MACACO II Compton camera |
Type |
Journal Article |
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Year |
2021 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
1014 |
Issue |
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Pages |
165702 - 7pp |
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Keywords |
Compton camera; Hadron therapy; LaBr3; Silicon photomultipliers |
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Abstract |
The IRIS group at IFIC-Valencia has developed a second version of a Compton camera prototype for hadron therapy treatment monitoring, with the aim of improving the performance with respect to its predecessor. The system is composed of three Lanthanum (III) bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs). The detector energy resolution has been improved to 5.6% FWHM at 511 keV and an angular resolution of 8.0 degrees has been obtained. Images of a Na-22 point-like source have been reconstructed selecting two and three interaction events. Moreover, the experimental data have been reproduced with Monte Carlo simulations using a Compton camera module (CCMod) in GATE v8.2 obtaining a good correlation. |
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Address |
[Barrientos, L.; Borja-Lloret, M.; Munoz, E.; Oliver, J. F.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G.] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: lbarrien@ific.uv.es |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000701263400010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4976 |
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