Abstract: The KM3NeT Collaboration is building and operating two deep sea neutrino telescopes at the bottom of the Mediterranean Sea. The telescopes consist of latices of photomultiplier tubes housed in pressure-resistant glass spheres, called digital optical modules and arranged in vertical detection units. The two main scientific goals are the determination of the neutrino mass ordering and the discovery and observation of high-energy neutrino sources in the Universe. Neutrinos are detected via the Cherenkov light, which is induced by charged particles originated in neutrino interactions. The photomultiplier tubes convert the Cherenkov light into electrical signals that are acquired and timestamped by the acquisition electronics. Each optical module houses the acquisition electronics for collecting and timestamping the photomultiplier signals with one nanosecond accuracy. Once finished, the two telescopes will have installed more than six thousand optical acquisition nodes, completing one of the more complex networks in the world in terms of operation and synchronization. The embedded software running in the acquisition nodes has been designed to provide a framework that will operate with different hardware versions and functionalities. The hardware will not be accessible once in operation, which complicates the embedded software architecture. The embedded software provides a set of tools to facilitate remote manageability of the deployed hardware, including safe reconfiguration of the firmware. This paper presents the architecture and the techniques, methods and implementation of the embedded software running in the acquisition nodes of the KM3NeT neutrino telescopes. Program summary Program title: Embedded software for the KM3NeT CLB CPC Library link to program files: https://doi.org/10.17632/s847hpsns4.1 Licensing provisions: GNU General Public License 3 Programming language: C Nature of problem: The challenge for the embedded software in the KM3NeT neutrino telescope lies in orchestrating the Digital Optical Modules (DOMs) to achieve the synchronized data acquisition of the incoming optical signals. The DOMs are the crucial component responsible for capturing neutrino interactions deep underwater. The embedded software must configure and precisely time the operation of each DOM. Any deviation or timing mismatch could compromise data integrity, undermining the scientific value of the experiment. Therefore, the embedded software plays a critical role in coordinating, synchronizing, and operating these modules, ensuring they work in unison to capture and process neutrino signals accurately, ultimately advancing our understanding of fundamental particles in the Universe. Solution method: The embedded software on the DOMs provides a solution based on a C-based bare-metal application, operating without a real-time embedded OS. It is loaded into the RAM during FPGA configuration, consuming less than 256 kB of RAM. The software architecture comprises two layers: system software and application. The former offers OS-like features, including a multitasking scheduler, firmware updates, peripheral drivers, a UDP-based network stack, and error handling utilities. The application layer contains a state machine ensuring consistent program states. It is navigated via slow control events, including external inputs and autonomous responses. Subsystems within the application code control specific acquisition electronics components via the associated driver abstractions. Additional comments including restrictions and unusual features: Due to the operation conditions of the neutrino telescope, where access is restricted, the embedded software implements a fail-safe procedure to reconfigure the firmware where the embedded software runs.

Abstract: The framed standard model (FSM), constructed to explain, with some success, why there should be three and apparently only three generations of quarks and leptons in nature falling into a hierarchical mass and mixing pattern,(10) suggests also, among other things, a scalar boson U, with mass around 17 MeV and small couplings to quarks and leptons,(11) which might explain(9) the g – 2 anomaly reported in experiment.(12) The U arises in FSM initially as a state in the predicted “hidden sector” with mass around 17 MeV, which mixes with the standard model (SM) Higgs h(W), acquiring thereby a coupling to quarks and leptons and a mass just below 17 MeV. The initial purpose of this paper is to check whether this proposal is compatible with experiment on semileptonic decays of Ks and Bs where the U can also appear. The answer to this we find is affirmative, in that the contribution of U to new physics as calculated in the FSM remains within the experimental bounds, but only if m(U) lies within a narrow range just below the unmixed mass. As a result from this, one has an estimate m(U) similar to 15-17 MeV for the mass of U, and from some further considerations the estimate Gamma(U) similar to 0.02 eV for its width, both of which may be useful for an eventual search for it in experiment. If found, it will be, for the FSM, not just the discovery of a predicted new particle, but the opening of a window into a whole “hidden sector” containing at least some, perhaps even the bulk, of the dark matter in the universe.

Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.

Abstract: BackgroundNon-melanoma skin cancer is one of the most common types of cancer and one of the main approaches is brachytherapy. For small lesions, the treatment of this cancer with brachytherapy can be done with two commercial applicators, one of these is the Large Field Valencia Applicators (LFVA).PurposeThe aim of this study is to test the capabilities of the LFVA to use clinically 60Co sources instead of the 192Ir ones. This study was designed for the same dwell positions and weights for both sources.MethodsThe Penelope Monte Carlo code was used to evaluate dose distribution in a water phantom when a 60Co source is considered. The LFVA design and the optimized dwell weights reported for the case of 192Ir are maintained with the only exception of the dwell weight of the central position, that was increased. 2D dose distributions, field flatness, symmetry and the leakage dose distribution around the applicator were calculated.ResultsWhen comparing the dose distributions of both sources, field flatness and symmetry remain unchanged. The only evident difference is an increase of the penumbra regions for all depths when using the 60Co source. Regarding leakage, the maximum dose within the air volume surrounding the applicator is in the order of 20% of the prescription dose for the 60Co source, but it decreases to less than 5% at about 1 cm distance.ConclusionsFlatness and symmetry remains unaltered as compared with 192Ir sources, while an increase in leakage has been observed. This proves the feasibility of using the LFVA in a larger range of clinical applications.

Abstract: The need to achieve high energies in particle accelerators has led to the development of new accelerator technologies, resulting in higher beam intensities and more compact devices with stronger accelerating fields. In such scenarios, beam-loading effects occur, and intensity-dependent gradient reduction affects the accelerated beam as a consequence of its interaction with the surrounding cavity. In this study, a power-diffusive partial differential equation is derived to account for this effect. Its numerical resolution has been implemented in the tracking code RF-Track, allowing the simulation of apparatuses where transient beam loading plays an important role. Finally, measurements of this effect have been carried out in the CERN Linear Electron Accelerator for Research (CLEAR) facility at CERN, finding good agreement with the RF-Track simulations.