Abstract: The Dresden-II reactor experiment has recently reported a suggestive evidence for the observation of coherent elastic neutrino-nucleus scattering, using a germanium detector. Given the low recoil energy threshold, these data are particularly interesting for a low-energy determination of the weak mixing angle and for the study of new physics leading to spectral distortions at low momentum transfer. Using two hypotheses for the quenching factor, we study the impact of the data on: (i) The weak mixing angle at a renormalization scale of similar to 10 MeV, (ii) neutrino generalized interactions with light mediators, (iii) the sterile neutrino dipole portal. The results for the weak mixing angle show a strong dependence on the quenching factor choice. Although still with large uncertainties, the Dresden-II data provide for the first time a determination of sin(2)theta(W) at such scale using coherent elastic neutrino-nucleus scattering data. Tight upper limits are placed on the light vector, scalar and tensor mediator scenarios. Kinematic constraints implied by the reactor anti-neutrino flux and the ionization energy threshold allow the sterile neutrino dipole portal to produce up-scattering events with sterile neutrino masses up to similar to 8 MeV. In this context, we find that limits are also sensitive to the quenching factor choice, but in both cases competitive with those derived from XENON1T data and more stringent that those derived with COHERENT data, in the same sterile neutrino mass range.