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Author |
Sanjuan, R.; Nebot, M.; Chirico, N.; Mansky, L.M.; Belshaw, R. |
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Title |
Viral Mutation Rates |
Type |
Journal Article |
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Year |
2010 |
Publication |
Journal of Virology |
Abbreviated Journal |
J. Virol. |
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Volume |
84 |
Issue |
19 |
Pages |
9733-9748 |
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Keywords |
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Abstract |
Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut. |
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Address |
[Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolutiva, Dept Genet, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Amer Soc Microbiology |
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Language |
English |
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ISSN |
0022-538x |
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Notes |
ISI:000282641800008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
371 |
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Author |
BABAR Collaboration (del Amo Sanchez, P. et al); Azzolini, V.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D.A.; Oyanguren, A. |
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Title |
Test of Lepton Universality in Y(1S) Decays at BABAR |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
104 |
Issue |
19 |
Pages |
191801 - 7pp |
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Keywords |
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Abstract |
The ratio R-tau mu(Y(1S)) = Gamma Y(1S)->tau(+)tau(-)/Gamma(+)(-)(Y(1S)->mu)(mu) is measured using a sample of (121.8 +/- 1.2) x 10(6)Y(3S) events recorded by the BABAR detector. This measurement is intended as a test of lepton universality and as a search for a possible light pseudoscalar Higgs boson. In the standard model (SM) this ratio is expected to be close to 1. Any significant deviations would violate lepton universality and could be introduced by the coupling to a light pseudoscalar Higgs boson. The analysis studies the decays Y(3S) -> Y(1S)pi(+)pi(-), Y(1S) -> l(+)l(-), where l = mu, tau. The result, R-tau μ(Y(1S)) = 1.005 +/- 0.013(stat) +/- 0.022(syst), shows no deviation from the expected SM value, while improving the precision with respect to previous measurements. |
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Address |
[Sanchez, P. del Amo; Lees, J. P.; Poireau, V.; Prencipe, E.; Tisserand, V.] Univ Savoie, Lab Annecy Le Vieux Phys Particules, CNRS, IN2P3, F-74941 Annecy Le Vieux, France |
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Corporate Author |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Expedition |
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Conference |
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Notes |
ISI:000277699600013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
451 |
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Author |
Catford, W.N. et al; Caballero, L.; Rubio, B. |
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Title |
Migration of Nuclear Shell Gaps Studied in the d(Ne-24, p gamma)Ne-25 Reaction |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
104 |
Issue |
19 |
Pages |
192501 - 4pp |
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Keywords |
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Abstract |
The transfer of neutrons onto Ne-24 has been measured using a reaccelerated radioactive beam of Ne-24 to study the (d, p) reaction in inverse kinematics. The unusual raising of the first 3/2(+) level in Ne-25 and its significance in terms of the migration of the neutron magic number from N = 20 to N = 16 is put on a firm footing by confirmation of this state's identity. The raised 3/2(+) level is observed simultaneously with the intruder negative parity 7/2(-) and 3/2(-) levels, providing evidence for the reduction in the N = 20 gap. The coincident gamma-ray decays allowed the assignment of spins as well as the transferred orbital angular momentum. The excitation energy of the 3/2(+) state shows that the established USD shell model breaks down well within the sd model space and requires a revised treatment of the proton-neutron monopole interaction. |
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Address |
[Catford, W. N.; Timis, C. N.; Baldwin, T. D.; Gelletly, W.; Pain, S. D.] Univ Surrey, Dept Phys, Guildford GU2 5XH, Surrey, England |
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Publisher |
Amer Physical Soc |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Expedition |
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Conference |
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Notes |
ISI:000277699600014 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
452 |
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Permanent link to this record |
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Author |
MiniBooNE Collaboration (Aguilar-Arevalo, A.A. et al); Sorel, M. |
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Title |
Event Excess in the MiniBooNE Search for (nu)over-bar(mu) -> (nu)over-bar(e) Oscillations |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
105 |
Issue |
18 |
Pages |
181801 - 5pp |
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Keywords |
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Abstract |
The MiniBooNE experiment at Fermilab reports results from a search for (nu) over bar (mu) -> (nu) over bar (e) oscillations, using a data sample corresponding to 5.66 x 10(20) protons on target. An excess of 20.9 +/- 14.0 events is observed in the energy range 475 < E-nu(QE) < 1250 MeV, which, when constrained by the observed <(nu)over bar>(mu) events, has a probability for consistency with the background-only hypothesis of 0.5%. On the other hand, fitting for (nu) over bar (mu) -> (nu) over bar (e) oscillations, the best-fit point has chi(2) probability of 8.7%. The data are consistent with (nu) over bar (mu) -> (nu) over bar (e) oscillations in the 0.1 to 1.0 eV(2) Delta m(2) range and with the evidence for antineutrino oscillations from the Liquid Scintillator Neutrino Detector at Los Alamos National Laboratory. |
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Address |
[Dharmapalan, R.; Perevalov, D.; Stancu, I.] Univ Alabama, Tuscaloosa, AL 35487 USA |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Expedition |
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Conference |
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Notes |
ISI:000283492000002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
263 |
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Permanent link to this record |
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Author |
BABAR Collaboration (del Amo Sanchez, P. et al); Lopez-March, N.; Martinez-Vidal, F.; Milanes, D.A.; Oyanguren, A. |
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Title |
Search for f(J)(2220) in Radiative J/psi Decays |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
105 |
Issue |
17 |
Pages |
172001 - 7pp |
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Keywords |
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Abstract |
We present a search for f(J)(2220) production in radiative J/psi --> gamma f(J)(2220) decays using 460 fb(-1) of data collected with the BABAR detector at the SLAC PEP-II e(+)e(-) collider. The f(J)(2220) is searched for in the decays to K+K- and (KSKS0)-K-0. No evidence of this resonance is observed, and 90% confidence level upper limits on the product of the branching fractions for J/psi --> gamma f(J)(2220) and f(J)(2220) --> K+K-((KSKS0)-K-0) as a function of spin and helicity are set at the level of 10(-5), below the central values reported by the Mark III experiment. |
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Address |
[Sanchez, P. del Amo; Lees, J. P.; Poireau, V.; Prencipe, E.; Tisserand, V.] Univ Savoie, Lab Annecy Le Vieux Phys Particules LAPP, CNRS, IN2P3, F-74941 Annecy Le Vieux, France |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000283126900005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
351 |
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Permanent link to this record |