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Author |
Muñoz, E.; Barrio, J.; Bernabeu, J.; Etxebeste, A.; Lacasta, C.; Llosa, G.; Ros, A.; Roser, J.; Oliver, J.F. |
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Title |
Study and comparison of different sensitivity models for a two-plane Compton camera |
Type |
Journal Article |
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Year |
2018 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
63 |
Issue  |
13 |
Pages |
135004 - 19pp |
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Keywords |
Compton camera imaging; MLEM; Monte Carlo simulations; image quality |
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Abstract |
Given the strong variations in the sensitivity of Compton cameras for the detection of events originating from different points in the field of view (FoV), sensitivity correction is often necessary in Compton image reconstruction. Several approaches for the calculation of the sensitivity matrix have been proposed in the literature. While most of these models are easily implemented and can be useful in many cases, they usually assume high angular coverage over the scattered photon, which is not the case for our prototype. In this work, we have derived an analytical model that allows us to calculate a detailed sensitivity matrix, which has been compared to other sensitivity models in the literature. Specifically, the proposed model describes the probability of measuring a useful event in a two-plane Compton camera, including the most relevant physical processes involved. The model has been used to obtain an expression for the system and sensitivity matrices for iterative image reconstruction. These matrices have been validated taking Monte Carlo simulations as a reference. In order to study the impact of the sensitivity, images reconstructed with our sensitivity model and with other models have been compared. Images have been reconstructed from several simulated sources, including point-like sources and extended distributions of activity, and also from experimental data measured with Na-22 sources. Results show that our sensitivity model is the best suited for our prototype. Although other models in the literature perform successfully in many scenarios, they are not applicable in all the geometrical configurations of interest for our system. In general, our model allows to effectively recover the intensity of point-like sources at different positions in the FoV and to reconstruct regions of homogeneous activity with minimal variance. Moreover, it can be employed for all Compton camera configurations, including those with low angular coverage over the scatterer. |
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Address |
[Munoz, Enrique; Barrio, John; Bernabeu, Jose; Etxebeste, Ane; Lacasta, Carlos; Llosa, Gabriela; Ros, Ana; Roser, Jorge; Oliver, Josep F.] Univ Valencia, CSIC, Inst Fis Corpuscular, IFIC, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
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Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Notes |
WOS:000436390800004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
3639 |
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Author |
Araujo Filho, A.A. |
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Title |
Thermodynamics of massless particles in curved spacetime |
Type |
Journal Article |
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Year |
2023 |
Publication |
International Journal of Geometric Methods in Modern Physics |
Abbreviated Journal |
Int. J. Geom. Methods Mod. Phys. |
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Volume |
12 |
Issue |
13 |
Pages |
2350226 - 40pp |
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Keywords |
Einstein-aether; thermodynamic properties; curved spacetime |
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Abstract |
This work is devoted to study the behavior of massless particles within the context of curved spacetime. In essence, we investigate the consequences of the scale factor C(?) of the Friedmann-Robertson-Walker metric in the Einstein-aether formalism to study photon-like particles. To do so, we consider the system within the canonical ensemble formalism in order to derive the following thermodynamic state quantities: spectral radiance, Helmholtz free energy, pressure, entropy, mean energy and the heat capacity. Moreover, the correction to the Stefan-Boltzmann law and the equation of states are also provided. Particularly, we separate our study within three distinct cases, i.e. s = 0, p = 0; s = 1, p = 1; s = 2, p = 1. In the first one, the results are derived numerically. Nevertheless, for the rest of the cases, all the calculations are accomplished analytically showing explicitly the dependence of the scale factor C(?) and the Riemann zeta function ?(s). Furthermore, our analyses are accomplished in general taking into account three different regimes of temperature of the universe, i.e. the inflationary era (T = 10(13)GeV), the electroweak epoch (T = 10(3)GeV) and the cosmic microwave background (T = 10(-13)GeV). |
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Address |
[Araujo Filho, A. A.] Univ Fed Cearra UFC, Dept Fis, Campus Pici,CP 6030, BR-60455760 Fortaleza, CE, Brazil, Email: dilto@fisica.ufc.br |
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World Scientific Publ Co Pte Ltd |
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English |
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ISSN |
0219-8878 |
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Notes |
WOS:001048378900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5613 |
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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Publisher |
Mdpi |
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English |
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Notes |
WOS:001269841000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
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Title |
Measurement of the CKM angle gamma from a combination of LHCb results |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
12 |
Issue |
12 |
Pages |
087 - 59pp |
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Keywords |
B physics; CKM angle gamma; CP violation; Hadron-Hadron scattering (experiments) |
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Abstract |
A combination of measurements sensitive to the CKM angle gamma from LHCb is performed. The inputs are from analyses of time-integrated B+ -> DK+, B-0 -> DK*(0), B-0 -> DK+ pi(-) and B+ -> DK+ pi(+) pi(-) tree-level decays. In addition, results from a time-dependent analysis of B-s(0) -> (DsK +/-)-K--/+ decays are included. The combination yields = (72: 2(-7.3)(+6:8) 7 : 3)degrees, where the uncertainty includes systematic effects. The 95.5% confidence level interval is determined to be gamma is an element of [55.9, 85.2]degrees. A second combination is investigated, also including measurements from B+ -> DK+, B-0 -> DK*(0), B-0 -> DK+ pi(-) and B+ -> DK+ pi(+) pi decays, which yields compatible results. |
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Address |
[Bediagal, I.; De Miranda, J. M.; Rodrigues, F. Ferreira; Gomes, A.; Massafferri, A.; dos Reis, A. C.; Rodrigues, A. B.; Vieira, D.] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil |
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Publisher |
Springer |
Place of Publication |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:000391387400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2947 |
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Author |
Aguilera-Verdugo, J.J.; Driencourt-Mangin, F.; Plenter, J.; Ramirez-Uribe, S.; Rodrigo, G.; Sborlini, G.F.R.; Torres Bobadilla, W.J.; Tracz, S. |
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Title |
Causality, unitarity thresholds, anomalous thresholds and infrared singularities from the loop-tree duality at higher orders |
Type |
Journal Article |
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Year |
2019 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
12 |
Issue |
12 |
Pages |
163 - 12pp |
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Keywords |
Duality in Gauge Field Theories; Perturbative QCD; Scattering Amplitudes |
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Abstract |
We present the first comprehensive analysis of the unitarity thresholds and anomalous thresholds of scattering amplitudes at two loops and beyond based on the loop- tree duality, and show how non-causal unphysical thresholds are locally cancelled in an efficient way when the forest of all the dual on-shell cuts is considered as one. We also prove that soft and collinear singularities at two loops and beyond are restricted to a compact region of the loop three-momenta, which is a necessary condition for implementing a local cancellation of loop infrared singularities with the ones appearing in real emission; without relying on a subtraction formalism. |
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Address |
[Aguilera-Verdugo, J. Jesus; Driencourt-Mangin, Felix; Plenter, Judith; Ramirez-Uribe, Selomit; Rodrigo, German; Sborlini, German F. R.; Torres Bobadilla, William J.; Tracz, Szymon] Univ Valencia, Consejo Super Invest Cient, Inst Fis Corpuscular, Parc Cient, E-46980 Valencia, Spain, Email: jesus.aguilera@ific.uv.es; |
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Publisher |
Springer |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
1029-8479 |
ISBN |
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Conference |
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Notes |
WOS:000513535500003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4288 |
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