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Author |
Solevi, P.; Magrin, G.; Moro, D.; Mayer, R. |
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Title |
Monte Carlo study of microdosimetric diamond detectors |
Type |
Journal Article |
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Year |
2015 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
60 |
Issue  |
18 |
Pages |
7069-7083 |
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Keywords |
ion-beam therapy; microdosimetry; diamonds; GATE |
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Abstract |
Ion-beam therapy provides a high dose conformity and increased radiobiological effectiveness with respect to conventional radiation-therapy. Strict constraints on the maximum uncertainty on the biological weighted dose and consequently on the biological weighting factor require the determination of the radiation quality, defined as the types and energy spectra of the radiation at a specific point. However the experimental determination of radiation quality, in particular for an internal target, is not simple and the features of ion interactions and treatment delivery require dedicated and optimized detectors. Recently chemical vapor deposition (CVD) diamond detectors have been suggested as ion-beam therapy microdosimeters. Diamond detectors can be manufactured with small cross sections and thin shapes, ideal to cope with the high fluence rate. However the sensitive volume of solid state detectors significantly deviates from conventional microdosimeters, with a diameter that can be up to 1000 times the height. This difference requires a redefinition of the concept of sensitive thickness and a deep study of the secondary to primary radiation, of the wall effects and of the impact of the orientation of the detector with respect to the radiation field. The present work intends to study through Monte Carlo simulations the impact of the detector geometry on the determination of radiation quality quantities, in particular on the relative contribution of primary and secondary radiation. The dependence of microdosimetric quantities such as the unrestricted linear energy L and the lineal energy y are investigated for different detector cross sections, by varying the particle type (carbon ions and protons) and its energy. |
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Address |
[Solevi, Paola; Magrin, Giulio; Mayer, Ramona] EBG MedAustron, A-2700 Wiener Neustadt, Austria, Email: paola.solevi@ovgu.de |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:000361124000004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2379 |
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Author |
Muñoz, E.; Barrio, J.; Etxebeste, A.; Ortega, P.G.; Lacasta, C.; Oliver, J.F.; Solaz, C.; Llosa, G. |
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Title |
Performance evaluation of MACACO: a multilayer Compton camera |
Type |
Journal Article |
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Year |
2017 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
62 |
Issue |
18 |
Pages |
7321-7341 |
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Keywords |
Compton imaging; Compton camera; continuous LaBr3 crystal; silicon photomultiplier; hadron therapy |
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Abstract |
Compton imaging devices have been proposed and studied for a wide range of applications. We have developed a Compton camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs), to be used for proton range verification in hadron therapy. In this work, we present the results obtained with our prototype in laboratory tests with radioactive sources and in simulation studies. Images of a Na-22 and an Y-88 radioactive sources have been successfully reconstructed. The full width half maximum of the reconstructed images is below 4 mm for a Na-22 source at a distance of 5 cm. |
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Address |
[Munoz, Enrique; Barrio, John; Etxebeste, Ane; Ortega, Pablo G.; Lacasta, Carlos; Oliver, Josep F.; Solaz, Carles; Llosa, Gabriela] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
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Publisher |
Iop Publishing Ltd |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:000408229900003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3253 |
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Author |
Di Valentino, E.; Mena, O.; Pan, S.; Visinelli, L.; Yang, W.Q.; Melchiorri, A.; Mota, D.F.; Riess, A.G.; Silk, J. |
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Title |
In the realm of the Hubble tension – a review of solutions |
Type |
Journal Article |
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Year |
2021 |
Publication |
Classical and Quantum Gravity |
Abbreviated Journal |
Class. Quantum Gravity |
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Volume |
38 |
Issue |
15 |
Pages |
153001 - 110pp |
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Keywords |
cosmological parameters; cosmology; dark energy; Hubble constant |
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Abstract |
The simplest ΛCDM model provides a good fit to a large span of cosmological data but harbors large areas of phenomenology and ignorance. With the improvement of the number and the accuracy of observations, discrepancies among key cosmological parameters of the model have emerged. The most statistically significant tension is the 4 sigma to 6 sigma disagreement between predictions of the Hubble constant, H (0), made by the early time probes in concert with the 'vanilla' ΛCDM cosmological model, and a number of late time, model-independent determinations of H (0) from local measurements of distances and redshifts. The high precision and consistency of the data at both ends present strong challenges to the possible solution space and demands a hypothesis with enough rigor to explain multiple observations-whether these invoke new physics, unexpected large-scale structures or multiple, unrelated errors. A thorough review of the problem including a discussion of recent Hubble constant estimates and a summary of the proposed theoretical solutions is presented here. We include more than 1000 references, indicating that the interest in this area has grown considerably just during the last few years. We classify the many proposals to resolve the tension in these categories: early dark energy, late dark energy, dark energy models with 6 degrees of freedom and their extensions, models with extra relativistic degrees of freedom, models with extra interactions, unified cosmologies, modified gravity, inflationary models, modified recombination history, physics of the critical phenomena, and alternative proposals. Some are formally successful, improving the fit to the data in light of their additional degrees of freedom, restoring agreement within 1-2 sigma between Planck 2018, using the cosmic microwave background power spectra data, baryon acoustic oscillations, Pantheon SN data, and R20, the latest SH0ES Team Riess, et al (2021 Astrophys. J. 908 L6) measurement of the Hubble constant (H (0) = 73.2 +/- 1.3 km s(-1) Mpc(-1) at 68% confidence level). However, there are many more unsuccessful models which leave the discrepancy well above the 3 sigma disagreement level. In many cases, reduced tension comes not simply from a change in the value of H (0) but also due to an increase in its uncertainty due to degeneracy with additional physics, complicating the picture and pointing to the need for additional probes. While no specific proposal makes a strong case for being highly likely or far better than all others, solutions involving early or dynamical dark energy, neutrino interactions, interacting cosmologies, primordial magnetic fields, and modified gravity provide the best options until a better alternative comes along. |
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Address |
[Di Valentino, Eleonora] Univ Durham, Inst Particle Phys Phenomenol, Dept Phys, Durham DH1 3LE, England, Email: eleonora.di-valentino@durham.ac.uk |
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Publisher |
Iop Publishing Ltd |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
0264-9381 |
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Conference |
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Notes |
WOS:000672148200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4931 |
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Author |
Roser, J.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Muñoz, E.; Ros, A.; Viegas, R.; Llosa, G. |
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Title |
Joint image reconstruction algorithm in Compton cameras |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
67 |
Issue |
15 |
Pages |
155009 - 15pp |
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Keywords |
Compton camera; compton imaging; hadron therapy; image reconstruction; LM-MLEM; Monte Carlo simulations; multi-layer compton telescope |
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Abstract |
Objective. To demonstrate the benefits of using an joint image reconstruction algorithm based on the List Mode Maximum Likelihood Expectation Maximization that combines events measured in different channels of information of a Compton camera. Approach. Both simulations and experimental data are employed to show the algorithm performance. Main results. The obtained joint images present improved image quality and yield better estimates of displacements of high-energy gamma-ray emitting sources. The algorithm also provides images that are more stable than any individual channel against the noisy convergence that characterizes Maximum Likelihood based algorithms. Significance. The joint reconstruction algorithm can improve the quality and robustness of Compton camera images. It also has high versatility, as it can be easily adapted to any Compton camera geometry. It is thus expected to represent an important step in the optimization of Compton camera imaging. |
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Address |
[Roser, J.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Munoz, E.; Ros, A.; Viegas, R.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Jorge.Roser@ific.uv.es |
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Corporate Author |
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Publisher |
IOP Publishing Ltd |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
0031-9155 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000827830200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5298 |
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Author |
Solevi, P.; Muñoz, E.; Solaz, C.; Trovato, M.; Dendooven, P.; Gillam, J.E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Torres-Espallardo, I.; Llosa, G. |
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Title |
Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams |
Type |
Journal Article |
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Year |
2016 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
61 |
Issue |
14 |
Pages |
5149-5165 |
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Keywords |
ion-beam therapy; range verification; prompt gamma; Compton camera; GATE |
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Abstract |
In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy. |
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Address |
[Solevi, Paola; Munoz, Enrique; Solaz, Carles; Trovato, Marco; Gillam, John E.; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Torres-Espallardo, Irene; Llosa, Gabriela] IFIC CSIC UVEG, Inst Fis Corpuscular, Valencia, Spain, Email: paola.solevi@ovgu.de |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9155 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000379555300007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2754 |
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