Abstract: One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.

Abstract: The Earth is bombarded by ultrarelativistic particles, known as cosmic rays (CRs). CRs with energies up to a few PeV (=10(15) eV), the knee in the particle spectrum, are believed to have a Galactic origin. One or more factories of PeV CRs, or PeVatrons, must thus be active within our Galaxy. The direct detection of PeV protons from their sources is not possible since they are deflected in the Galactic magnetic fields. Hundred TeV gamma-rays from decaying pi(0), produced when PeV CRs collide with the ambient gas, can provide the decisive evidence of proton acceleration up to the knee. Here we report the discovery by the High Altitude Water Cerenkov (HAWC) observatory of the gamma-ray source, HAWC J1825-134, whose energy spectrum extends well beyond 200 TeV without a break or cutoff. The source is found to be coincident with a giant molecular cloud. The ambient gas density is as high as 700 protons cm(-3). While the nature of this extreme accelerator remains unclear, CRs accelerated to energies of several PeV colliding with the ambient gas likely produce the observed radiation.

Abstract: A measurement of CP-violating observables is performed using the decays B-+/- -> DK +/- and B-+/- -> D pi(+/-), where the D meson is reconstructed in one of the self-conjugate three-body final states K-S(0)pi(+)pi(-) and (KSK+K-)-K-0 (commonly denoted K(S)(0)h(+)h(-)). The decays are analysed in bins of the D-decay phase space, leading to a measurement that is independent of the modelling of the D-decay amplitude. The observables are inter- preted in terms of the CKM angle gamma. Using a data sample corresponding to an integrated luminosity of 9 fb(-1) collected in proton-proton collisions at centre-of mass energies of 7, 8, and 13 TeV with the LHCb experiment, gamma is measured to be (68.7(-5.1)(+5.2))degrees. The hadronic parameters r(B)(DK), r(B)(D pi), delta(DK)(B), and delta(D pi)(B), which are the ratios and strong-phase differences of the suppressed and favoured B-+/- decays, are also reported.