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Author Strege, C.; Bertone, G.; Feroz, F.; Fornasa, M.; Ruiz de Austri, R.; Trotta, R. url  doi
openurl 
  Title Global fits of the cMSSM and NUHM including the LHC Higgs discovery and new XENON100 constraints Type Journal Article
  Year 2013 Publication Journal of Cosmology and Astroparticle Physics Abbreviated Journal J. Cosmol. Astropart. Phys.  
  Volume 04 Issue (down) 4 Pages 013 - 40pp  
  Keywords dark matter theory; supersymmetry and cosmology  
  Abstract We present global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM) and the Non-Universal Higgs Model (NUHM), including the most recent CMS constraint on the Higgs boson mass, 5.8 fb(-1) integrated luminosity null Supersymmetry searches by ATLAS, the new LHCb measurement of B R ((B) over bar (s) -> mu(+) mu(-)) and the 7-year WMAP dark matter relic abundance determination. We include the latest dark matter constraints from the XENON100 experiment, marginalising over astrophysical and particle physics uncertainties. We present Bayesian posterior and profile likelihood maps of the highest resolution available today, obtained from up to 350M points. We find that the new constraint on the Higgs boson mass has a dramatic impact, ruling out large regions of previously favoured cMSSM and NUHM parameter space. In the cMSSM, light sparticles and predominantly gaugino-like dark matter with a mass of a few hundred GeV are favoured. The NUHM exhibits a strong preference for heavier sparticle masses and a Higgsino-like neutralino with a mass of 1 TeV. The future ton-scale XENON1T direct detection experiment will probe large portions of the currently favoured cMSSM and NUHM parameter space. The LHC operating at 14 TeV collision energy will explore the favoured regions in the cMSSM, while most of the regions favoured in the NUHM will remain inaccessible. Our best-fit points achieve a satisfactory quality-of-fit, with p-values ranging from 0.21 to 0.35, so that none of the two models studied can be presently excluded at any meaningful significance level.  
  Address Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Astrophys Grp, London SW7 2AZ, England, Email: charlotte.strege09@imperial.ac.uk;  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1475-7516 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000318556200013 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1445  
Permanent link to this record
 

 
Author Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. doi  openurl
  Title Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 Type Journal Article
  Year 2013 Publication Plos Biology Abbreviated Journal PLoS. Biol.  
  Volume 11 Issue (down) 4 Pages e1001523 - 10pp  
  Keywords  
  Abstract The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.  
  Address Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es  
  Corporate Author Thesis  
  Publisher Public Library Science Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1545-7885 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000318687800003 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 1446  
Permanent link to this record
 

 
Author Villaescusa-Navarro, F.; Vogelsberger, M.; Viel, M.; Loeb, A. url  doi
openurl 
  Title Neutrino signatures on the high-transmission regions of the Lyman alpha forest Type Journal Article
  Year 2013 Publication Monthly Notices of the Royal Astronomical Society Abbreviated Journal Mon. Not. Roy. Astron. Soc.  
  Volume 431 Issue (down) 4 Pages 3670-3677  
  Keywords neutrinos; intergalactic medium; quasars: absorption lines; cosmology: theory; large-scale structure of Universe  
  Abstract We quantify the impact of massive neutrinos on the statistics of low-density regions in the intergalactic medium as probed by the Lyman alpha forest at redshifts z = 2.2-4. Based on mock but realistic quasar (QSO) spectra extracted from hydrodynamic simulations with cold dark matter, baryons and neutrinos, we find that the probability distribution of weak Lyman alpha absorption features, as sampled by Lyman alpha flux regions at high transmissivity, is strongly affected by the presence of massive neutrinos. We show that systematic errors affecting the Lyman alpha forest reduce but do not erase the neutrino signal. Using the Fisher matrix formalism, we conclude that the sum of the neutrino masses can be measured, using the method proposed in this paper, with a precision smaller than 0.4 eV using a catalogue of 200 high-resolution (signal-to-noise ratio similar to 100) QSO spectra. This number reduces to 0.27 eV by making use of reasonable priors in the other parameters that also affect the statistics of the high-transitivity regions of the Lyman alpha forest. The constraints obtained with this method can be combined with independent bounds from the cosmic microwave background, large-scale structures and measurements of the matter power spectrum from the Lyman alpha forest to produce tighter upper limits on the sum of the masses of the neutrinos.  
  Address Univ Valencia, IFIC, CSIC, E-46071 Valencia, Spain, Email: viel@oats.inaf.it  
  Corporate Author Thesis  
  Publisher Oxford Univ Press Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0035-8711 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000319479000057 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1458  
Permanent link to this record
 

 
Author Vincent, A.C.; Scott, P.; Trampedach, R. url  doi
openurl 
  Title Light bosons in the photosphere and the solar abundance problem Type Journal Article
  Year 2013 Publication Monthly Notices of the Royal Astronomical Society Abbreviated Journal Mon. Not. Roy. Astron. Soc.  
  Volume 432 Issue (down) 4 Pages 3332-3339  
  Keywords elementary particles; line: formation; Sun: abundances; Sun: atmosphere; cosmology: theory  
  Abstract Spectroscopy is used to measure the elemental abundances in the outer layers of the Sun, whereas helioseismology probes the interior. It is well known that current spectroscopic determinations of the chemical composition are starkly at odds with the metallicity implied by helioseismology. We investigate whether the discrepancy may be due to conversion of photons to a new light boson in the solar photosphere. We examine the impact of particles with axion-like interactions with the photon on the inferred photospheric abundances, showing that resonant axion-photon conversion is not possible in the region of the solar atmosphere in which line formation occurs. Although non-resonant conversion in the line-forming regions can in principle impact derived abundances, constraints from axion-photon conversion experiments rule out the couplings necessary for these effects to be detectable. We show that this extends to hidden photons and chameleons (which would exhibit similar phenomenological behaviour), ruling out known theories of new light bosons as photospheric solutions to the solar abundance problem.  
  Address [Vincent, A. C.] Univ Valencia, IFIC, CSIC, E-46071 Valencia, Spain, Email: vincent@ific.uv.es  
  Corporate Author Thesis  
  Publisher Oxford Univ Press Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0035-8711 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000321053500058 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1481  
Permanent link to this record
 

 
Author Baker, M.J.; Bordes, J.; Hong-Mo, C.; Tsun, T.S. url  doi
openurl 
  Title On the corner elements of the CKM and PMNS matrices Type Journal Article
  Year 2013 Publication Europhysics Letters Abbreviated Journal EPL  
  Volume 102 Issue (down) 4 Pages 41001 - 6pp  
  Keywords  
  Abstract Recent experiments show that the top-right corner element (U-e3) of the PMNS matrix is small but nonzero, and suggest further via unitarity that it is smaller than the bottom-left corner element (U-tau 1). Here, it is shown that if to the assumption of a universal rank-one mass matrix, long favoured by phenomenologists, one adds that this matrix rotates with scale, then it follows that A) by inputting the mass ratios m(c)/m(t), m(s)/m(b), m(mu)/m(tau), and m(2)/m(3), i) the corner elements are small but nonzero, ii) V-ub < V-td, U-e3 < U-tau 1, iii) estimates result for the ratios V-ub/V-td and U-e3/U-tau 1, and B) by inputting further the experimental values of V-us, V-tb and U-e2, U-mu 3, iv) estimates result for the values of the corner elements themselves. All the inequalities and estimates obtained are consistent with present data within expectation for the approximations made.  
  Address [Baker, Michael J.; Bordes, Jose] Univ Valencia, Dept Fis Teor, E-46100 Burjassot, Valencia, Spain  
  Corporate Author Thesis  
  Publisher Epl Association, European Physical Society Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0295-5075 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000321118600014 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1511  
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