Strege, C., Bertone, G., Feroz, F., Fornasa, M., Ruiz de Austri, R., & Trotta, R. (2013). Global fits of the cMSSM and NUHM including the LHC Higgs discovery and new XENON100 constraints. J. Cosmol. Astropart. Phys., 04(4), 013–40pp.
Abstract: We present global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM) and the Non-Universal Higgs Model (NUHM), including the most recent CMS constraint on the Higgs boson mass, 5.8 fb(-1) integrated luminosity null Supersymmetry searches by ATLAS, the new LHCb measurement of B R ((B) over bar (s) -> mu(+) mu(-)) and the 7-year WMAP dark matter relic abundance determination. We include the latest dark matter constraints from the XENON100 experiment, marginalising over astrophysical and particle physics uncertainties. We present Bayesian posterior and profile likelihood maps of the highest resolution available today, obtained from up to 350M points. We find that the new constraint on the Higgs boson mass has a dramatic impact, ruling out large regions of previously favoured cMSSM and NUHM parameter space. In the cMSSM, light sparticles and predominantly gaugino-like dark matter with a mass of a few hundred GeV are favoured. The NUHM exhibits a strong preference for heavier sparticle masses and a Higgsino-like neutralino with a mass of 1 TeV. The future ton-scale XENON1T direct detection experiment will probe large portions of the currently favoured cMSSM and NUHM parameter space. The LHC operating at 14 TeV collision energy will explore the favoured regions in the cMSSM, while most of the regions favoured in the NUHM will remain inaccessible. Our best-fit points achieve a satisfactory quality-of-fit, with p-values ranging from 0.21 to 0.35, so that none of the two models studied can be presently excluded at any meaningful significance level.
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Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
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Villaescusa-Navarro, F., Vogelsberger, M., Viel, M., & Loeb, A. (2013). Neutrino signatures on the high-transmission regions of the Lyman alpha forest. Mon. Not. Roy. Astron. Soc., 431(4), 3670–3677.
Abstract: We quantify the impact of massive neutrinos on the statistics of low-density regions in the intergalactic medium as probed by the Lyman alpha forest at redshifts z = 2.2-4. Based on mock but realistic quasar (QSO) spectra extracted from hydrodynamic simulations with cold dark matter, baryons and neutrinos, we find that the probability distribution of weak Lyman alpha absorption features, as sampled by Lyman alpha flux regions at high transmissivity, is strongly affected by the presence of massive neutrinos. We show that systematic errors affecting the Lyman alpha forest reduce but do not erase the neutrino signal. Using the Fisher matrix formalism, we conclude that the sum of the neutrino masses can be measured, using the method proposed in this paper, with a precision smaller than 0.4 eV using a catalogue of 200 high-resolution (signal-to-noise ratio similar to 100) QSO spectra. This number reduces to 0.27 eV by making use of reasonable priors in the other parameters that also affect the statistics of the high-transitivity regions of the Lyman alpha forest. The constraints obtained with this method can be combined with independent bounds from the cosmic microwave background, large-scale structures and measurements of the matter power spectrum from the Lyman alpha forest to produce tighter upper limits on the sum of the masses of the neutrinos.
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Vincent, A. C., Scott, P., & Trampedach, R. (2013). Light bosons in the photosphere and the solar abundance problem. Mon. Not. Roy. Astron. Soc., 432(4), 3332–3339.
Abstract: Spectroscopy is used to measure the elemental abundances in the outer layers of the Sun, whereas helioseismology probes the interior. It is well known that current spectroscopic determinations of the chemical composition are starkly at odds with the metallicity implied by helioseismology. We investigate whether the discrepancy may be due to conversion of photons to a new light boson in the solar photosphere. We examine the impact of particles with axion-like interactions with the photon on the inferred photospheric abundances, showing that resonant axion-photon conversion is not possible in the region of the solar atmosphere in which line formation occurs. Although non-resonant conversion in the line-forming regions can in principle impact derived abundances, constraints from axion-photon conversion experiments rule out the couplings necessary for these effects to be detectable. We show that this extends to hidden photons and chameleons (which would exhibit similar phenomenological behaviour), ruling out known theories of new light bosons as photospheric solutions to the solar abundance problem.
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Baker, M. J., Bordes, J., Hong-Mo, C., & Tsun, T. S. (2013). On the corner elements of the CKM and PMNS matrices. EPL, 102(4), 41001–6pp.
Abstract: Recent experiments show that the top-right corner element (U-e3) of the PMNS matrix is small but nonzero, and suggest further via unitarity that it is smaller than the bottom-left corner element (U-tau 1). Here, it is shown that if to the assumption of a universal rank-one mass matrix, long favoured by phenomenologists, one adds that this matrix rotates with scale, then it follows that A) by inputting the mass ratios m(c)/m(t), m(s)/m(b), m(mu)/m(tau), and m(2)/m(3), i) the corner elements are small but nonzero, ii) V-ub < V-td, U-e3 < U-tau 1, iii) estimates result for the ratios V-ub/V-td and U-e3/U-tau 1, and B) by inputting further the experimental values of V-us, V-tb and U-e2, U-mu 3, iv) estimates result for the values of the corner elements themselves. All the inequalities and estimates obtained are consistent with present data within expectation for the approximations made.
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