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Author |
Peris, J.B.; Davis, P.; Cuevas, J.M.; Nebot, M.; Sanjuan, R. |
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Title |
Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1 |
Type |
Journal Article |
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Year |
2010 |
Publication |
Genetics |
Abbreviated Journal |
Genetics |
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Volume |
185 |
Issue  |
2 |
Pages |
603-U308 |
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Abstract |
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria. |
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Address |
[Peris, Joan B.; Davis, Paulina; Cuevas, Jose M.; Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Genetics Soc Am |
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English |
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ISSN |
0016-6731 |
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Notes |
ISI:000281905200017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
383 |
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Author |
Noguera, S.; Vento, V. |
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Title |
The pion transition form factor and the pion distribution amplitude |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
46 |
Issue |
2 |
Pages |
197-205 |
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Keywords |
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Abstract |
Recent BaBar data on the pion transition form factor, whose Q(2)-dependence is much steeper then predicted by asymptotic Quantum Chromodynamics (QCD), have caused a renewed interest in its theoretical description. We present here a formalism based on a model-independent description for low photon virtuality and a high photon virtuality description based on QCD, which match at a scale Q(0). The high photon virtuality description incorporates a flat pion distribution amplitude, phi(x) = 1, at the matching scale Q(0) and QCD evolution from Q(0) to Q > Q(0). The flat pion distribution is connected, through soft pion theorems and chiral symmetry, to the pion valence parton distribution at the same low scale Q(0). The procedure leads to a good description of the data, and by incorporating additional twist-three effects, to an excellent description of the data. |
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Address |
[Noguera, S.] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Valencia, Spain, Email: Santiago.Noguera@uv.es |
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Springer |
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English |
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ISSN |
1434-6001 |
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Notes |
ISI:000284869600005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
312 |
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Author |
Kaskulov, M.; Hernandez, E.; Oset, E. |
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Title |
On the background in the gamma p -> omega(pi(0)gamma)p reaction and mixed event simulation |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
46 |
Issue |
2 |
Pages |
223-230 |
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Abstract |
In this paper we evaluate sources of background of the gamma p -> omega p reaction, with the omega detected through its pi(0)gamma decay channel, to compare with the experiment carried out at ELSA. We find background from gamma p -> pi(0)pi(0)p followed by decay of a pi(0) into two gamma, recombining one pi(0) and one gamma, and from the gamma p -> pi(0)eta p reaction with subsequent decay of the eta into two photons. This background accounts for the data at pi(0)gamma invariant masses beyond 700 MeV, but strength is missing at lower invariant masses which was attributed to photon misidentification events, which we simulate to get a good reproduction of the experimental background. Once this is done, we perform an event mixing simulation to reproduce the calculated background and we find that the method provides a good description of the background. A closer look reveals this is accidental. We show that the mixed event generated background in the region of the omega mass and beyond is completely tied to the events at low pi(0)gamma invariant masses where the d sigma/dM(pi 0 gamma) distribution is much larger. This has as a consequence that the mixed event method produces the same background at high invariant masses independently of the actual background in that region, as a consequence of which, the method is unsuited to give the background at energies around the peak of the omega and beyond. |
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Address |
[Kaskulov, M.] Univ Giessen, Inst Theoret Phys, D-35392 Giessen, Germany, Email: murat.kaskulov@theo.physik.uni-giessen.de |
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Springer |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Conference |
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Notes |
ISI:000284869600008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
313 |
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Author |
Doring, M.; Oset, E.; Meissner, U.G. |
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Title |
Evaluation of the polarization observables I-S and I-C in the reaction gamma p -> pi(0)eta p |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
46 |
Issue |
2 |
Pages |
315-323 |
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Keywords |
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Abstract |
We evaluate the polarization observables I-S and I-C for the reaction gamma p -> pi(0)eta p, using a chiral unitary framework developed earlier. The I-S and I-C observables have been recently measured for the first time by the CBELSA/TAPS Collaboration. The theoretical predictions of I-S and I-C, given for altogether 18 angle-dependent functions, are in good agreement with the measurements. Also, the asymmetry d Sigma/dcos theta evaluated here agrees with the data. We show the importance of the Delta(1700) D-33-resonance and its S-wave decay into eta Delta(1232). The result can be considered as a further confirmation of the dynamical nature of this resonance. At the highest energies, deviations of the predictions from the data start to become noticeable, which leaves room for additional processes and resonances such as a Delta(1940) D-33. We also point out how to further improve the calculation. |
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Address |
[Doering, M.; Meissner, U. -G.] Forschungszentrum Julich, Inst Kernphys, D-52425 Julich, Germany, Email: m.doering@fz-juelich.de |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Conference |
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Notes |
ISI:000284869600016 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
314 |
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Author |
HADES Collaboration (Agakishiev, G. et al); Diaz, J.; Gil, A. |
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Title |
Origin of the low-mass electron pair excess in light nucleus-nucleus collisions |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
690 |
Issue |
2 |
Pages |
118-122 |
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Keywords |
Virtual bremsstrahlung; Dileptons; Nucleon-nucleon collisions |
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Abstract |
We report measurements of electron pair production in elementary p + p and d + p reactions at 1.25 GeV/mu with the HADES spectrometer. For the first time, the electron pairs were reconstructed for n + p reactions by detecting the proton spectator from the deuteron breakup. We find that the yield of electron pairs with invariant mass Me+e- > 0.15 GeV/c(2) is about an order of magnitude larger in n + p reactions as compared to p + p. A comparison to model calculations demonstrates that the production mechanism is not sufficiently described yet. The electron pair spectra measured in C + C reactions are compatible with a superposition of elementary n + p and p + p collisions, leaving little room for additional electron pair sources in such light collision systems. |
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Address |
[Froehlich, I.; Galatyuk, T.; Goebel, K.; Lorenz, M.; Markert, J.; Michel, J.; Muentz, C.; Pachmayer, Y. C.; Stroebele, H.; Stroth, J.; Sturm, C.; Tarantola, A.; Teilab, K.] Goethe Univ Frankfurt, Inst Kernphys, D-60438 Frankfurt, Germany, Email: t.galatyuk@gsi.de |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Medium |
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Notes |
ISI:000279513800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
413 |
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