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Author |
Verdu-Andres, S.; Amaldi, U.; Faus-Golfe, A. |
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Title |
CABOTO, a high-gradient linac for hadrontherapy |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Radiation Research |
Abbreviated Journal |
J. Radiat. Res. |
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Volume |
54 |
Issue  |
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Pages |
155-161 |
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Keywords |
hadrontherapy; high-gradient linac; cyclinac; carbon ion therapy; multipainting |
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Abstract |
The field of hadrontherapy has grown rapidly in recent years. At present the therapeutic beam is provided by a cyclotron or a synchrotron, but neither cyclotrons nor synchrotrons present the best performances for hadrontherapy. The new generation of accelerators for hadrontherapy should allow fast active energy modulation and have a high repetition rate, so that moving organs can be appropriately treated in a reasonable time. In addition, a reduction of the dimensions and cost of the accelerators for hadrontherapy would make the acquisition and operation of a hadrontherapy facility more affordable, which would translate into great benefits for the potential hadrontherapy patients. The 'cyclinac', an accelerator concept that combines a cyclotron with a high-frequency linear accelerator (linac), is a fast-cycling machine specifically conceived to allow for fast active energy modulation. The present paper focuses on CABOTO (CArbon BOoster for Therapy in Oncology), a compact, efficient high-frequency linac that can accelerate C6+ ions and H-2 molecules from 150-410 MeV/u in similar to 24 m. The paper presents the latest design of CABOTO and discusses its performances. |
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Address |
[Verdu-Andres, Silvia; Amaldi, Ugo] Fdn Tera, I-28100 Novara, Italy, Email: sverdu@bnl.gov |
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Publisher |
Oxford Univ Press |
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English |
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ISSN |
0449-3060 |
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Conference |
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Notes |
WOS:000321463900021 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1506 |
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Author |
Oliver, S.; Vijande, J.; Tejedor-Aguilar, N.; Miro, R.; Rovira-Escutia, J.J.; Ballester, F.; Juste, B.; Carmona, V.; Felici, G.; Verdu, G.; Sanchis, E.; Conde, A.; Perez-Calatayud, J. |
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Title |
Monte Carlo flattening filter design to high energy intraoperative electron beam homogenization |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
212 |
Issue |
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Pages |
111102 - 6pp |
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Keywords |
Intraoperative radiotherapy; Electron portable LinAc; Flattening filter; Dosimetry; Monte Carlo |
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Abstract |
Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice. |
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Address |
[Oliver, S.; Miro, R.; Juste, B.; Verdu, G.] Univ Polite cn Vale ncia, Inst Segur Ind Radiofis & Medioambiental ISIRYM, Cami Vera S-N, Valencia 46022, Spain, Email: gverdu@iqn.upv.es |
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Pergamon-Elsevier Science Ltd |
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English |
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ISSN |
0969-806x |
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Expedition |
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Conference |
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Notes |
WOS:001026194900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5578 |
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Author |
Martinez-Reviriego, P.; Esperante, D.; Grudiev, A.; Gimeno, B.; Blanch, C.; Gonzalez-Iglesias, D.; Fuster-Martinez, N.; Martin-Luna, P.; Martinez, E.; Menendez, A.; Fuster, J. |
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Title |
Dielectric assist accelerating structures for compact linear accelerators of low energy particles in hadrontherapy treatments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Frontiers in Physics |
Abbreviated Journal |
Front. Physics |
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Volume |
12 |
Issue |
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Pages |
1345237 - 12pp |
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Keywords |
dielectric assist accelerating (DAA) structures; radio frequency (RF); LINAC; hadrontherapy; standing wave |
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Abstract |
Dielectric Assist Accelerating (DAA) structures based on ultralow-loss ceramic are being studied as an alternative to conventional disk-loaded copper cavities. This accelerating structure consists of dielectric disks with irises arranged periodically in metallic structures working under the TM02-pi mode. In this paper, the numerical design of an S-band DAA structure for low beta particles, such as protons or carbon ions used for Hadrontherapy treatments, is shown. Four dielectric materials with different permittivity and loss tangent are studied as well as different particle velocities. Through optimization, a design that concentrates most of the RF power in the vacuum space near the beam axis is obtained, leading to a significant reduction of power loss on the metallic walls. This allows to fabricate cavities with an extremely high quality factor, over 100,000, and shunt impedance over 300 M omega/m at room temperature. During the numerical study, the design optimization has been improved by adjusting some of the cell parameters in order to both increase the shunt impedance and reduce the peak electric field in certain locations of the cavity, which can lead to instabilities in its normal functioning. |
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Address |
[Martinez-Reviriego, Pablo; Esperante, Daniel; Gimeno, Benito; Blanch, Cesar; Gonzalez-Iglesias, Daniel; Fuster-Martinez, Nuria; Martin-Luna, Pablo; Martinez, Eduardo; Menendez, Abraham; Fuster, Juan] CSIC Univ Valencia, Inst Fis Corpuscular IFIC, Paterna, Spain, Email: pablo.martinez.reviriego@ific.uv.es |
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Publisher |
Frontiers Media Sa |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2296-424x |
ISBN |
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Conference |
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Notes |
WOS:001162373700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5953 |
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Author |
Olivares Herrador, J.; Latina, A.; Aksoy, A.; Fuster Martinez, N.; Gimeno, B.; Esperante, D. |
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Title |
Implementation of the beam-loading effect in the tracking code RF-track based on a power-diffusive model |
Type |
Journal Article |
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Year |
2024 |
Publication |
Frontiers in Physics |
Abbreviated Journal |
Front. Physics |
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Volume |
12 |
Issue |
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Pages |
1348042 - 11pp |
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Keywords |
beam loading; LINAC; energy loss; tracking simulation; transient; high-intensity beam; CLEAR; gradient reduction |
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Abstract |
The need to achieve high energies in particle accelerators has led to the development of new accelerator technologies, resulting in higher beam intensities and more compact devices with stronger accelerating fields. In such scenarios, beam-loading effects occur, and intensity-dependent gradient reduction affects the accelerated beam as a consequence of its interaction with the surrounding cavity. In this study, a power-diffusive partial differential equation is derived to account for this effect. Its numerical resolution has been implemented in the tracking code RF-Track, allowing the simulation of apparatuses where transient beam loading plays an important role. Finally, measurements of this effect have been carried out in the CERN Linear Electron Accelerator for Research (CLEAR) facility at CERN, finding good agreement with the RF-Track simulations. |
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Address |
[Olivares Herrador, Javier; Latina, Andrea; Aksoy, Avni] CERN, Meyrin, Switzerland, Email: javier.olivares.herrador@cern.ch |
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Publisher |
Frontiers Media Sa |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2296-424x |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001193122800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6019 |
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Author |
Degiovanni, A.; Amaldi, U.; Bonomi, R.; Garlasche, M.; Garonna, A.; Verdu-Andres, S.; Wegner, R. |
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Title |
TERA high gradient test program of RF cavities for medical linear accelerators |
Type |
Journal Article |
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Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
657 |
Issue |
1 |
Pages |
55-58 |
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Keywords |
Medical accelerators; Hadrontherapy; Cyclinac; Linac; RF cavity; Breakdown Rate |
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Abstract |
The scientific community and the medical industries are putting a considerable effort into the design of compact, reliable and cheap accelerators for hadrontherapy. Up to now only circular accelerators are used to deliver beams with energies suitable for the treatment of deep seated tumors. The TERA Foundation has proposed and designed a hadrontherapy facility based on the cyclinac concept: a high gradient linear accelerator placed downstream of a cyclotron used as an injector. The overall length of the linac, and therefore its final cost, is almost inversely proportional to the average accelerating gradient achieved in the linac. TERA, in collaboration with the CLIC RF group, has started a high gradient test program. The main goal is to study the high gradient behavior of prototype cavities and to determine the appropriate linac operating frequency considering important issues such as machine reliability and availability of distributed power sources. A preliminary test of a 3 GHz cavity has been carried out at the beginning of 2010, giving encouraging results. Further investigations are planned before the end of 2011. A set of 5.7 GHz cavities is under production and will be tested in a near future. The construction and test of a multi-cell structure is also foreseen. |
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Address |
[Degiovanni, A; Wegner, R] CERN, CH-1211 Geneva, Switzerland, Email: alberto.degiovanni@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000297085800010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
807 |
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