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Author |
Barrientos, L.; Borja-Lloret, M.; Etxebeste, A.; Muñoz, E.; Oliver, J.F.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G. |
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Title |
Performance evaluation of MACACO II Compton camera |
Type |
Journal Article |
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Year |
2021 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
1014 |
Issue ![sorted by Issue field, ascending order (up)](img/sort_asc.gif) |
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Pages |
165702 - 7pp |
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Keywords |
Compton camera; Hadron therapy; LaBr3; Silicon photomultipliers |
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Abstract |
The IRIS group at IFIC-Valencia has developed a second version of a Compton camera prototype for hadron therapy treatment monitoring, with the aim of improving the performance with respect to its predecessor. The system is composed of three Lanthanum (III) bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs). The detector energy resolution has been improved to 5.6% FWHM at 511 keV and an angular resolution of 8.0 degrees has been obtained. Images of a Na-22 point-like source have been reconstructed selecting two and three interaction events. Moreover, the experimental data have been reproduced with Monte Carlo simulations using a Compton camera module (CCMod) in GATE v8.2 obtaining a good correlation. |
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Address |
[Barrientos, L.; Borja-Lloret, M.; Munoz, E.; Oliver, J. F.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G.] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: lbarrien@ific.uv.es |
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Publisher |
Elsevier |
Place of Publication |
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Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000701263400010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4976 |
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Permanent link to this record |
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Author |
Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Lopez, J.G.; Jimenez-Ramos, M.C.; Hueso-Gonzalez, F.; Ros, A.; Llosa, G. |
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Title |
Characterization of a Compton camera based on the TOFPET2 ASIC |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
202 |
Issue ![sorted by Issue field, ascending order (up)](img/sort_asc.gif) |
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Pages |
110507 - 11pp |
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Keywords |
Compton camera; Hadron therapy; LaBr3; PETsys TOFPET2; Silicon photomultipliers |
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Abstract |
The use of Compton cameras for medical imaging and its interest as a hadron therapy treatment monitoring has increased in the last decade with the development of silicon photomultipliers. MACACOp is a Compton camera prototype designed and assembled at the IRIS group of IFIC-Valencia. This Compton camera is based on monolithic Lanthanum (III) Bromide crystals and silicon photomultipliers, and employs the novel TOFPET2 ASIC as readout electronics. This system emerged as an alternative to MACACO II prototype, with the aim of improving its limited time resolution. To test the performance of the ASIC in a Compton camera setup, the prototype was characterized, both in laboratory and in-beam. A time resolution of 1.5 ns was obtained after time corrections, which improves greatly the performance of the MACACO II. Moreover, the results obtained at high photon energies demonstrate the ability of the system to obtain 1 mm displacements of the reconstructed spots. The results reinforce the potential of the system as a monitoring device for hadron therapy. |
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Address |
[Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casana, J., V; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Rita.Viegas@ific.uv.es |
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Publisher |
Pergamon-Elsevier Science Ltd |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0969-806x |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000870840600006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5392 |
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Permanent link to this record |
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Author |
Barrientos, L.; Borja-Lloret, M.; Casana, J.V.; Hueso-Gonzalez, F.; Ros, A.; Roser, J.; Senra, C.; Solaz, C.; Viegas, R.; Llosa, G. |
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Title |
System characterization and performance studies with MACACO III Compton camera |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
208 |
Issue ![sorted by Issue field, ascending order (up)](img/sort_asc.gif) |
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Pages |
110922 - 13pp |
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Keywords |
Compton camera; Scintillator crystals; Silicon photomultipliers |
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Abstract |
The IRIS group of IFIC-Valencia has developed a Compton camera prototype. The system detectors are made of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. Two models of silicon photomultipliers arrays with different micro pixel pitch (25 and 50 μm) have been chosen as possible candidates to improve the response of the new system. Characterization studies with a 22Na point-like source have indicated that the 25 μm photodetector provided better performance in terms of energy resolution (5.2% FWHM at 511 keV) and angular resolution (6.9 degrees FWHM at 1275 keV), and more stability with temperature variations. In addition, MACACO III imaging capabilities have been assessed using a structure composed of thirty-seven 22Na point-like sources. Furthermore, in order to evaluate possible ways of improving the system performance, several studies have been carried out by means of simulations both in realistic and performance improved conditions. In this work, the system performance is evaluated for its future application in different areas. |
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Address |
[Barrientos, L.; Borja-Lloret, M.; Casana, J. V.; Hueso-Gonzalez, F.; Ros, A.; Roser, J.; Senra, C.; Solaz, C.; Viegas, R.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IF, Valencia, Spain, Email: Luis.Barrientos@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Pergamon-Elsevier Science Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0969-806x |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000962800400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5511 |
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Permanent link to this record |
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Author |
Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Dendooven, P.; Garcia Lopez, J.G.; Hueso-Gonzalez, F.; Jiméeez-Ramos, M.C.; Perez-Curbelo, J.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G. |
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Title |
Gamma-ray sources imaging and test-beam results with MACACO III Compton camera |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physica Medica |
Abbreviated Journal |
Phys. Medica |
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Volume |
117 |
Issue ![sorted by Issue field, ascending order (up)](img/sort_asc.gif) |
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Pages |
103199 - 10pp |
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Keywords |
Hadron therapy; Compton camera; Scintillator crystals; Silicon photomultipliers |
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Abstract |
Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s. |
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Address |
[Barrientos, L.; Borja-Lloret, M.; Casana, J. V.; Hueso-Gonzalez, F.; Perez-Curbelo, J.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Luis.Barrientos@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Sci Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1120-1797 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001145147400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5892 |
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Permanent link to this record |
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Author |
Muñoz, E.; Ros, A.; Borja-Lloret, M.; Barrio, J.; Dendooven, P.; Oliver, J.F.; Ozoemelam, I.; Roser, J.; Llosa, G. |
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Title |
Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection |
Type |
Journal Article |
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Year |
2021 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
11 |
Issue ![sorted by Issue field, ascending order (up)](img/sort_asc.gif) |
1 |
Pages |
9325 - 12pp |
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Keywords |
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Abstract |
The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr3 scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. This work reports the results obtained from measurements of a 150 MeV proton beam impinging on a PMMA target. A neural network trained on Monte Carlo simulations is used for event selection, increasing the signal to background ratio before image reconstruction. Images of the measured prompt gamma distributions are reconstructed by means of a spectral reconstruction code, through which the 4.439 MeV spectral line is resolved. Images of the emission distribution at this energy are reconstructed, allowing calculation of the distal fall-off and identification of target displacements of 3 mm. |
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Address |
[Munoz, Enrique; Ros, Ana; Borja-Lloret, Marina; Barrio, John; Oliver, Josep F.; Roser, Jorge; Llosa, Gabriela] Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Nature Research |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2045-2322 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000651603500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4836 |
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Permanent link to this record |